2.4.1.133: xylosylprotein 4-beta-galactosyltransferase
This is an abbreviated version!
For detailed information about xylosylprotein 4-beta-galactosyltransferase, go to the full flat file.
Word Map on EC 2.4.1.133
-
2.4.1.133
-
proteoglycans
-
glycosaminoglycans
-
ehlers-danlos
-
beta-1,4-galts
-
progeroid
-
xylosyltransferase
-
larsen
-
hypermobility
-
b3galt6
-
laxity
-
hypermobl
-
reunion
-
linkeropathies
-
spondylodysplastic
-
hyperextensibility
-
drug development
- 2.4.1.133
- proteoglycans
- glycosaminoglycans
- ehlers-danlos
- beta-1,4-galts
-
progeroid
-
xylosyltransferase
-
larsen
- hypermobility
- b3galt6
- laxity
-
hypermobl
-
reunion
-
linkeropathies
-
spondylodysplastic
-
hyperextensibility
- drug development
Reaction
Synonyms
B4GALT7, beta-1,4 galactosyltransferase I, beta-1,4 galactosyltransferase V, beta-1,4-galactosyltransferase, beta-1,4-galactosyltransferase 7, beta-1,4-galactosyltransferase I, beta-1,4-galactosyltransferase-I, beta-1,4-galactosyltransferase-T7, beta-1,4-GalT, beta-1,4-GalT 7, beta-1,4-GalT I, beta-1,4-GalT V, beta-1,4-GalT-I, beta1,4-galactosyltransferase 7, beta1,4-galactosyltransferase I, beta1,4-galactosyltransferase VII, beta1,4-galactosyltransferase-7, beta1,4-GalT, beta1,4-GalT-I, beta1,4-GalT7, beta4-galactosyltransferase 7, beta4Gal-T7, beta4galactosyltransferase I, beta4GalT-7, beta4GalT7, dbeta4GalTI, galactosyltransferase I, galactosyltransferase, uridine diphosphogalactose-xylose, GalT I, GalT-I, hbeta4GalT7, MgGalT7, pNP-xylose-beta-1,4-galactosyltransferase, proteoglycan UDP-galactose:beta-xylose beta 1,4-galactosyltransferase I, SQV-3, UDP-D-galactose:D-xylose galactosyltransferase, UDP-D-galactose:xylose galactosyltransferase, UDP-galactose:O-beta-D-xylosylprotein 4-beta-D-galactosyltransferase, UDPgalactose:O-beta-D-xylosylprotein 4-beta-D-galactosyltransferase, xylosylprotein 4-beta-galactosyltransferase, xylosylprotein beta1,4-galactosyltransferase
ECTree
2.4.1.133 xylosylprotein 4-beta-galactosyltransferaseAdvanced search results
results (
results (Reference
top
Reference on EC 2.4.1.133 - xylosylprotein 4-beta-galactosyltransferase
Please use the Reference Search for a specific query.
Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
REF. 
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Schwartz, N.B.; Rodén, L.
Biosynthesis of chondroitin sulfate. Solubilization of chondroitin sulfate glycosyltransferases and partial purification of uridine diphosphate-D-galactose:D-xylose galactosyltrans
J. Biol. Chem.
250
5200-5207
1975
Gallus gallus
Schawrtz, N.
Biosynthesis of chondroitin sulfate. Role of phospholipids in the activity of UDP-D-galactose: D-xylose galactosyltransferase
J. Biol. Chem.
251
285-291
1976
Gallus gallus
Schwartz, N.B.; Rodén, L.; Dorfman, A.
Biosynthesis of chondroitin sulfate: interaction between xylosyltransferase and galactosyltransferase
Biochem. Biophys. Res. Commun.
56
717-724
1974
Gallus gallus
Gunasekaran, K.; Ma, B.; Ramakrishnan, B.; Qasba, P.K.; Nussinov, R.
Interdependence of backbone flexibility, residue conservation, and enzyme function: a case study on beta1,4-galactosyltransferase-I
Biochemistry
42
3674-3687
2003
Bos taurus (P08037)
Parker, G.J.; Handley, C.J.; Robinson, H.C.
An assay for galactosyltransferase-I activity in articular cartilage
Anal. Biochem.
226
154-160
1995
Bos taurus, Gallus gallus
Vadaie, N.; Hulinsky, R.S.; Jarvis, D.L.
Identification and characterization of a Drosophila melanogaster ortholog of human beta1,4-galactosyltransferase VII
Glycobiology
12
589-597
2002
Drosophila melanogaster
Higuchi, T.; Tamura, S.; Takagaki, K.; Nakamura, T.; Morikawa, A.; Tanaka, K.; Tanaka, A.; Saito, Y.; Endo, M.
A method for determination of galactosyltransferase I activity synthesizing the proteoglycan linkage region
J. Biochem. Biophys. Methods
29
135-142
1994
Homo sapiens
Ujita, M.; McAuliffe, J.; Hindsgaul, O.; Sasaki, K.; Fukuda, M.N.; Fukuda, M.
Poly-N-acetyllactosamine synthesis in branched N-glycans is controlled by complemental branch specificity of i-extension enzyme and beta1,4-galactosyltransferase I
J. Biol. Chem.
274
16717-16726
1999
Mus musculus
Higuchi, T.; Tamura, S.; Tanaka, K.; Takagaki, K.; Saito, Y.; Endo, M.
Effects of ATP on regulation of galactosyltransferase-I activity responsible for synthesis of the linkage region between the core protein and glycosaminoglycan chains of proteoglycans
Biochem. Cell Biol.
79
159-164
2001
Homo sapiens
Okajima, T.; Yoshida, K.; Kondo, T.; Furukawa, K.
Human homolog of Caenorhabditis elegans sqv-3 gene is galactosyltransferase I involved in the biosynthesis of the glucosaminoglycan-protein linkage region of proteoglycans
J. Biol. Chem.
274
22915-22918
1999
Homo sapiens
Charron, M.; Shaper, N.L.; Rajput, B.; Shaper, J.H.
A novel 14-base-pair regulatory element is essential for in vivo expression of murine beta4-galactosyltransferase-I in late pachytene spermatocytes and round spermatids
Mol. Cell. Biol.
19
5823-5832
1999
Mus musculus
Shi, X.; Amindari, S.; Paruchuru, K.; Skalla, D.; Burkin, H.; Shur, B.D.; Miller, D.J.
Cell surface beta1,4-galactosyltransferase-I activates G protein-dependent exocytotic signaling
Development
128
645-654
2001
Mus musculus
Zhou, D.; Malissard, M.; Berger, E.G.; Hennet, T.
Secretion and purification of recombinant beta1-4 galactosyltransferase from insect cells using pFmel-protA, a novel transposition-based baculovirus transfer vector
Arch. Biochem. Biophys.
374
3-7
2000
Homo sapiens
Bencurova, M.; Rendic, D.; Fabini, G.; Kopecky, E.M.; Altmann, F.; Wilson, I.B.H.
Expression of eukaryotic glycosyltransferases in the yeast Pichia pastoris
Biochimie
85
413-422
2003
Caenorhabditis elegans, Drosophila melanogaster
Takemae, H.; Ueda, R.; Okubo, R.; Nakato, H.; Izumi, S.; Saigo, K.; Nishihara, S.
Proteoglycan UDP-galactose:beta-xylose beta 1,4-galactosyltransferase I is essential for viability in Drosophila melanogaster
J. Biol. Chem.
278
15571-15578
2003
Drosophila melanogaster
Gulberti, S.; Lattard, V.; Fondeur, M.; Jacquinet, J.C.; Mulliert, G.; Netter, P.; Magdalou, J.; Ouzzine, M.; Fournel-Gigleux, S.
Phosphorylation and sulfation of oligosaccharide substrates critically influence the activity of human beta1,4-galactosyltransferase 7 (GalT-I) and beta1,3-glucuronosyltransferase I (GlcAT-I) involved in the biosynthesis of the glycosaminoglycan-protein linkage region of proteoglycans
J. Biol. Chem.
280
1417-1425
2005
Homo sapiens
Goette, M.; Kresse, H.
Defective glycosaminoglycan substitution of decorin in a patient with progeroid syndrome is a direct consequence of two point mutations in the galactosyltransferase I (beta4GalT-7) gene
Biochem. Genet.
43
65-77
2005
Homo sapiens
Seidler, D.G.; Faiyaz-Ul-Haque, M.; Hansen, U.; Yip, G.W.; Zaidi, S.H.; Teebi, A.S.; Kiesel, L.; Goette, M.
Defective glycosylation of decorin and biglycan, altered collagen structure, and abnormal phenotype of the skin fibroblasts of an Ehlers-Danlos syndrome patient carrying the novel Arg270Cys substitution in galactosyltransferase I (beta4GalT-7)
J. Mol. Med.
84
583-594
2006
Homo sapiens
Bakker, H.; Rouwendal, G.J.; Karnoup, A.S.; Florack, D.E.; Stoopen, G.M.; Helsper, J.P.; van Ree, R.; van Die, I.; Bosch, D.
An antibody produced in tobacco expressing a hybrid beta-1,4-galactosyltransferase is essentially devoid of plant carbohydrate epitopes
Proc. Natl. Acad. Sci. USA
103
7577-7582
2006
Homo sapiens (P15291), Homo sapiens
Goette, M.; Spillmann, D.; Yip, G.W.; Versteeg, E.; Echtermeyer, F.G.; van Kuppevelt, T.H.; Kiesel, L.
Changes in heparan sulfate are associated with delayed wound repair, altered cell migration, adhesion and contractility in the galactosyltransferase I (beta4GalT-7) deficient form of Ehlers-Danlos syndrome
Hum. Mol. Genet.
17
996-1009
2008
Homo sapiens
Daligault, F.; Rahuel-Clermont, S.; Gulberti, S.; Cung, M.T.; Branlant, G.; Netter, P.; Magdalou, J.; Lattard, V.
Thermodynamic insights into the structural basis governing the donor substrate recognition by human beta1,4-galactosyltransferase 7
Biochem. J.
418
605-614
2009
Homo sapiens (Q9UBV7), Homo sapiens
Yan, M.; Xia, C.; Niu, S.; Cheng, C.; Shao, X.; Shen, A.
The role of TNF-alpha and its receptors in the production of beta-1,4-galactosyltransferase I mRNA by rat primary type-2 astrocytes
Cell. Mol. Neurobiol.
28
223-236
2008
Rattus norvegicus (P80225)
Yang, H.; Hu, L.; Chen, J.; Zhu, J.; Tao, T.; Zhang, F.; Li, X.; He, X.; Shen, A.; Cheng, C.
Lipopolysaccharide induced upregulation of beta-1,4-galactosyltransferase-I in Schwann cell
Inflammation
32
279-286
2009
Rattus norvegicus
Yang, H.; Yan, M.; Cheng, C.; Jiang, J.; Zhang, L.; Liu, J.; Zhou, Z.; Shen, A.
Expression of beta-1,4-galactosyltransferase I in rat Schwann cells
J. Cell. Biochem.
108
75-86
2009
Rattus norvegicus
Niu, S.; Fei, M.; Cheng, C.; Yan, M.; Gao, S.; Chen, M.; Wang, H.; Li, X.; Yu, X.; Qian, J.; Qin, J.; Zhao, J.; Gu, J.; Shen, A.
Altered beta-1,4-galactosyltransferase I expression during early inflammation after spinal cord contusion injury
J. Chem. Neuroanat.
35
245-256
2008
Rattus norvegicus
Wei, Y.; Liu, D.; Zhou, F.; Ge, Y.; Xu, J.; Yun, X.; Gu, J.; Jiang, J.
Identification of beta-1,4-galactosyltransferase I as a target gene of HBx-induced cell cycle progression of hepatoma cell
J. Hepatol.
49
1029-1037
2008
Homo sapiens (P15291)
Yan, M.; Cheng, C.; Shao, X.; Qian, J.; Shen, A.; Xia, C.; Xia, C.
Expression change of beta-1,4 galactosyltransferase I, V mRNAs and Galbeta1,4GlcNAc group in rat sciatic nerve after crush
J. Mol. Histol.
39
317-328
2008
Rattus norvegicus
Chen, J.; Wang, H.; Yang, H.; Huang, X.; Zhu, J.; Hu, L.; Qian, J.; Yang, J.; Zhou, D.; Ni, X.; Shen, A.; Cheng, C.
beta-1,4-Galactosyltransferase-I participates in lipopolysaccharide induced reactive microgliosis
Neurotoxicology
30
1107-1113
2009
Rattus norvegicus
Rahuel-Clermont, S.; Daligault, F.; Piet, M.H.; Gulberti, S.; Netter, P.; Branlant, G.; Magdalou, J.; Lattard, V.
Biochemical and thermodynamic characterization of mutated beta1,4-galactosyltransferase 7 involved in the progeroid form of the Ehlers-Danlos syndrome
Biochem. J.
432
303-311
2010
Homo sapiens
Ramakrishnan, B.; Qasba, P.K.
Crystal structure of the catalytic domain of Drosophila beta1,4-Galactosyltransferase-7
J. Biol. Chem.
285
15619-15626
2010
Drosophila melanogaster (Q8T3P3)
Talhaoui, I.; Bui, C.; Oriol, R.; Mulliert, G.; Gulberti, S.; Netter, P.; Coughtrie, M.W.; Ouzzine, M.; Fournel-Gigleux, S.
Identification of key functional residues in the active site of human {beta}1,4-galactosyltransferase 7: a major enzyme in the glycosaminoglycan synthesis pathway
J. Biol. Chem.
285
37342-37358
2010
Homo sapiens (Q9UBV7)
Pasek, M.; Boeggeman, E.; Ramakrishnan, B.; Qasba, P.K.
Galectin-1 as a fusion partner for the production of soluble and folded human beta-1,4-galactosyltransferase-T7 in E. coli
Biochem. Biophys. Res. Commun.
394
679-684
2010
Homo sapiens
Bui, C.; Talhaoui, I.; Chabel, M.; Mulliert, G.; Coughtrie, M.W.; Ouzzine, M.; Fournel-Gigleux, S.
Molecular characterization of beta1,4-galactosyltransferase 7 genetic mutations linked to the progeroid form of Ehlers-Danlos syndrome (EDS)
FEBS Lett.
584
3962-3968
2010
Homo sapiens
Garcia-Garcia, J.F.; Corrales, G.; Casas, J.; Fernandez-Mayoralas, A.; Garcia-Junceda, E.
Synthesis and evaluation of xylopyranoside derivatives as decoy acceptors of human beta-1,4-galactosyltransferase 7
Mol. Biosyst.
7
1312-1321
2011
Homo sapiens
Gu, J.; Fan, J.; Xu, Y.; Xie, Y.; Gong, T.; Kong, Y.
Regulatory function of beta1,4-galactosyltransferase I expression on Lewis-Y glycan and embryo implantation
Gene
562
220-225
2015
Homo sapiens (P15291)
Tsutsui, Y.; Ramakrishnan, B.; Qasba, P.K.
Crystal structures of beta-1,4-galactosyltransferase 7 enzyme reveal conformational changes and substrate binding
J. Biol. Chem.
288
31963-31970
2013
Homo sapiens (Q9UBV7), Drosophila melanogaster (Q9VBZ9)
Saliba, M.; Ramalanjaona, N.; Gulberti, S.; Bertin-Jung, I.; Thomas, A.; Dahbi, S.; Lopin-Bon, C.; Jacquinet, J.C.; Breton, C.; Ouzzine, M.; Fournel-Gigleux, S.
Probing the acceptor active site organization of the human recombinant beta1,4-galactosyltransferase 7 and design of xyloside-based inhibitors
J. Biol. Chem.
290
7658-7670
2015
Homo sapiens (Q9UBV7)
Siegbahn, A.; Thorsheim, K.; Stahle, J.; Manner, S.; Hamark, C.; Persson, A.; Tykesson, E.; Mani, K.; Westergren-Thorsson, G.; Widmalm, G.; Ellervik, U.
Exploration of the active site of beta4GalT7: modifications of the aglycon of aromatic xylosides
Org. Biomol. Chem.
13
3351-3362
2015
Homo sapiens (Q9UBV7)
Song, H.B.; He, M.; Cai, Z.P.; Huang, K.; Flitsch, S.L.; Liu, L.; Voglmeir, J.
UDP-glucose 4-epimerase and ?-1,4-galactosyltransferase from the oyster Magallana gigas as valuable biocatalysts for the production of galactosylated products
Int. J. Mol. Sci.
19
1600
2018
Crassostrea gigas (K1QT40)
Thorsheim, K.; Willen, D.; Tykesson, E.; Stahle, J.; Praly, J.P.; Vidal, S.; Johnson, M.T.; Widmalm, G.; Manner, S.; Ellervik, U.
Naphthyl thio- and carba-xylopyranosides for exploration of the active site of beta-1,4-galactosyltransferase 7 (beta4GalT7)
Chemistry
23
18057-18065
2017
Homo sapiens (Q9UBV7)
html completed
