2.4.1.135: galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase

This is an abbreviated version!
For detailed information about galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase, go to the full flat file.

Word Map on EC 2.4.1.135

2.4.1.135

glycosaminoglycans

proteoglycans

glcat-s

killer-1

tetrasaccharide

trisaccharide

glycosaminoglycan-protein

n-acetyllactosamine

glucuronylation

udp-glca

hnk-1st

galbeta1-3glcnac

b3gat3

paragloboside

non-sulfated

Reaction

[protein]-3-O-(beta-D-galactosyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-xylosyl)-L-serine

[protein]-3-O-(beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl)-L-serine

Synonyms

beta-1,3-glucuronyltransferase 1, beta1,3-glucuronosyltransferase I, beta1,3-glucuronosyltransferase-I, beta1,3-glucuronyltransferase I, galactose beta1,3 glucuronosyl transferase-I, galactose beta1,3-glucuronosyltransferase-I, galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase, Galbeta1,3-glucuronosyltransferase, GlcAT-1, GlcAT-I, GlcAT-P, GlcATI, GlcUAT-I, glucuronosyltransferase I, glucuronyltransferase-I, glycosaminoglycan glucuronyltransferase I, glycosyltransferases GlcAT1, UDP-GlcUA:Gal Beta-1,3-Gal-R glucuronyltransferase, UDP-GlcUA:glycoprotein beta-1,3-glucuronyltransferase, UDP-glucuronic acid:Galbeta1,3Gal-R glucuronsyltransferase

ECTree

2 Transferases

2.4 Glycosyltransferases

2.4.1 Hexosyltransferases

2.4.1.135 galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase

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Results	in table
4376	AA Sequence
2	CAS Registry Number
14	Cloned(Commentary)
4	Crystallization (Commentary)
16	Disease/ Diagnostics
5	Expression
6	General Information
4	Inhibitors
31	KM Value [mM]
7	Localization
12	Metals/Ions
4	Molecular Weight [Da]
15	Natural Substrates/ Products (Substrates)
24	Organism
7	Pathway
12	PDB ID
4	pH Optimum
1	pH Range
1	Posttranslational Modification
37	Protein Variants
4	Purification (Commentary)
1	Reaction
1	Reaction Type
24	Reference
30	Source Tissue
2	Specific Activity [micromol/min/mg]
56	Substrates and Products (Substrate)
3	Subunits
34	Synonyms
1	Systematic Name
1	Temperature Optimum [°C]

KM Value

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KM Value on EC 2.4.1.135 - galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase

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0.0091

3-beta-galactosyl-galactose

Mus musculus

393084

0.035

Galbeta(1-3)Gal(6-O-sulfate)beta(1-4)Xyl(2-O-phosphate)beta1-O-Ser

Homo sapiens

pH 6.5, 2 mM MnCl2, 37°C

687722

0.049

Galbeta(1-3)Gal(6-O-sulfate)beta(1-4)Xylbeta1-O-Ser

Homo sapiens

pH 6.5, 2 mM MnCl2, 37°C

687722

0.0804

Galbeta(1-3)Galbeta(1-4)Xyl

Homo sapiens

393086

0.025

Galbeta(1-3)Galbeta(1-4)Xyl(2-O-phosphate)beta1-O-Ser

Homo sapiens

pH 6.5, 2 mM MnCl2, 37°C

687722

0.046

Galbeta(1-3)Galbeta(1-4)Xylbeta1-O-Ser

Homo sapiens

pH 6.5, 2 mM MnCl2, 37°C

687722

0.67

Galbeta1,3Galbeta-O-naphthalenemethanol

Cricetulus griseus

Q9WU47

pH 6.5, 37°C

659141

3.2

Galbeta1,3GalNAcbeta-O-naphthalenemethanol

Cricetulus griseus

Q9WU47

pH 6.5, 37°C

659141

2.9

Galbeta1,3GlcNAcbeta-O-naphthalenemethanol

Cricetulus griseus

Q9WU47

pH 6.5, 37°C

659141

1.8

Galbeta1,4GlcNAcbeta-O-naphthalenemethanol

Cricetulus griseus

Q9WU47

pH 6.5, 37°C

659141

4.48

Galbeta1-3Gal

Homo sapiens

37°C, pH 6.5

676957

0.0499 - 0.059

UDP-GlcA

2 entries

0.108

UDP-GlcNAc

Homo sapiens

Q9P2W7

pH 5.0, 37°C, mutant enzyme H308R

659180

0.233

UDP-glucose

Homo sapiens

Q9P2W7

pH 5.0, 37°C, mutant enzyme H308R

659180

0.04 - 1.27

UDP-glucuronate

10 entries

0.074

UDP-Man

Homo sapiens

Q9P2W7

pH 5.0, 37°C, mutant enzyme H308R

659180

0.00025 - 0.287

UDPglucuronate

4 entries

additional information

Homo sapiens

393088