2.4.1.142: chitobiosyldiphosphodolichol beta-mannosyltransferase
This is an abbreviated version!
For detailed information about chitobiosyldiphosphodolichol beta-mannosyltransferase, go to the full flat file.
Word Map on EC 2.4.1.142
-
2.4.1.142
-
oligosaccharide
-
n-glycosylation
-
mannosylation
-
dolichol-linked
-
lipid-linked
-
n-linked
-
n-glycans
-
asparagine-linked
-
disease-causing
-
glycosylphosphatidylinositol
-
glycolipids
-
rough
-
pharmacology
- 2.4.1.142
- oligosaccharide
-
n-glycosylation
-
mannosylation
-
dolichol-linked
-
lipid-linked
-
n-linked
- n-glycans
-
asparagine-linked
-
disease-causing
- glycosylphosphatidylinositol
- glycolipids
-
rough
- pharmacology
Reaction
Synonyms
ALG1, ALG1 beta1,4 mannosyltransferase, Alg1 mannosyltransferase, Alg1 protein, Alg1p, beta-1,4 mannosyltransferase, beta1,4-MT, chitobiosyldiphosphodolichol beta-mannosyltransferase, GDP-Man:GlcNAc2-PP-dolichol mannosyltransferase, GDP-mannose-dolichol diphosphochitobiose mannosyltransferase, guanosine diphosphate-mannose:GlcNAc2-PP-dolichol mannosyltransferase-1, guanosine diphosphomannose-dolichol diphosphochitobiose mannosyltransferase, mannosyltransferase I, MT-1, MT-I
ECTree
Advanced search results
Natural Substrates Products
Natural Substrates Products on EC 2.4.1.142 - chitobiosyldiphosphodolichol beta-mannosyltransferase
Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
REACTION DIAGRAM
GDP-alpha-D-mannose + chitobiosyldiphosphodolichol
GDP + beta-(1->4)-D-mannosylchitobiosyldiphosphodolichol
GDP-alpha-D-mannose + N-acetyl-beta-D-glucosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl-diphosphodolichol
GDP + beta-D-mannosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl-diphosphodolichol
GDP + beta-(1->4)-D-mannosylchitobiosyldiphosphodolichol
-
-
-
?
GDP-alpha-D-mannose + chitobiosyldiphosphodolichol
GDP + beta-(1->4)-D-mannosylchitobiosyldiphosphodolichol
-
-
-
-
?
GDP-alpha-D-mannose + N-acetyl-beta-D-glucosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl-diphosphodolichol
GDP + beta-D-mannosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl-diphosphodolichol
-
-
-
?
GDP-alpha-D-mannose + N-acetyl-beta-D-glucosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl-diphosphodolichol
GDP + beta-D-mannosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl-diphosphodolichol
-
-
-
?
GDP-alpha-D-mannose + N-acetyl-beta-D-glucosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl-diphosphodolichol
GDP + beta-D-mannosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl-diphosphodolichol
-
-
-
?
GDP-alpha-D-mannose + N-acetyl-beta-D-glucosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl-diphosphodolichol
GDP + beta-D-mannosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl-diphosphodolichol
-
-
-
-
?
GDP-alpha-D-mannose + N-acetyl-beta-D-glucosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl-diphosphodolichol
GDP + beta-D-mannosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl-diphosphodolichol
-
-
-
?
?
-
-
patient with congenital disorder of glycosylation is compound heterozygous for three mutations in the ALG1 gene, leading to the amino acid substitutions S150R and D429E on one allele and S258L on the other. The detrimental effect of these mutations on ALG1 protein function is demonstrated in a complementation assay. This novel type of congenital disorder of glycosylation should be referred to as CDG-Ik
-
-
?
additional information
?
-
-
the molecular nature of severe multisystemic disorder with a recurrent nonimmune hydrops fetalis is identified as deficiency of GDP-Man:GlcNAc2-PP-dolichol mannosyltransferase caused by a C773T transition
-
-
?
additional information
?
-
-
two distinct complexes that contain multiple copies of Alg1 mannosyltransferase are identified. The two Alg1-containing complexes differ from one another in that one complex contains Alg2 and the other contains Alg11. Physical association of the functionally related catalytic enzymes involved in lipid-linked oligosaccharide synthesis provides an additional level of regulation that assures proper construction of the complex oligosaccharides
-
-
?