This is an abbreviated version! For detailed information about beta-1,4-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase, go to the full flat file.
(GnT)-III, acetylglucosaminyltransferase, uridine diphosphoacetylglucosamine-glycopeptide beta4-, III, beta(1,4)-N-acetylglucosaminyltransferase III, beta-1,4-mannosyl-glycoprotein beta-1,4-N-acetylglucosaminyltransferase, beta-1,4-N-acetylglucosaminyltransferase III, beta-D-mannoside beta-1,4-N-acetylglucosaminyltransferase, beta1,4-N-acetylglucosaminyltransferase III, EC 2.4.1.51, GlcNAc-transferase-III, GlcNAcTase-III, GnT-III, GnTIII, Golgi beta-1,4-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase III, MGAT3, N-acetyl-glucosaminyltransferase III, N-acetylglucosaminyltransferase III, N-acetylglucosaminyltransferase-III, N-glycosyl-oligosaccharide-glycoprotein N-acetylglucosaminyltransferase III, uridine diphosphate (UDP)-N-acetylglucosamin/beta-D-mannoside beta-1,4-N-acetylglucosaminyltransferase III, uridine diphosphoacetylglucosamine-glycopeptide beta4-acetylglucosaminyltransferase III
enzyme activity in extrahepatic bile duct carcinoma is increased 3fold compared to mean enzyme activity values, resulting in increased bisecting-GlcNAc on the glycans of glycoproteins in cancer tissues and a 201 kDa bile glycoprotein
apart from GnT-III overexpression, engineering of GnT-III localization is a versatile tool to modulate the biological activities of antibodies relevant for their therapeutic application
the majority of N-glycans of a recombinant antibody produced in Nicotiana tabacum expressing GnT-III is bisected and devoid of paucimannosidic structures. This might improve the efficacy of therapeutic antibodies produced in the transgenic plants
overexpression of enzyme in human hepatoma cells fails to reduce branch formation of N-glycans, coexpression of caveolin-1 leads to a dramatic decrease in the extent of branching with no enhancement of enzyme activity
RC12 cells, apheochromocytoma cell line, transfected with enzyme gene, result in suppression of neurite outgrowth induced by costimulation of epidermal growth factor and integrins. Epidermal growth factor receptor-mediated ERK-activation is blocked in transfectants. Epidermal growth factor receptor of transfectants is modified by bisecting GlcNAc in its N-glycan structures
transfection of mouse aorta endothelial cells with enzyme results in reduction of their susceptibility to complement-mediated cell lysis by normal human serum and suppresses the antigenicity of cells to human natural antibodies. Reactivity of glycoproteins of transfectants to normal human serum and GSIB4 lectin is reduced
introduction of human N-acetylglucosaminyltransferase gene into tobacco plants leads to highly efficient synthesis of bisected N-glycans. The majority of N-glycans of an antibody produced in a plant expressing GnT-III is also bisected. This might improve the efficacy of therapeutic antibodies produced in this type of transgenic plant