2.4.1.145: alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase This is an abbreviated version! For detailed information about alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase, go to the full flat file .
Word Map on EC 2.4.1.145
Reaction
UDP-N-acetyl-alpha-D-glucosamine +
beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc-N-Asn-[protein] =
UDP +
beta-D-GlcNAc-(1->2)-[beta-D-GlcNAc-(1->4)]-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc-N-Asn-[protein]
Synonyms (GnT)-IVa, (GnT)-IVb, alpha-1,3-mannosylglycoprotein beta-1,4-N-acetylglucosaminyltransferase, alpha1,3-mannosyl-beta1,4-N-acetylglucosaminyltransferase IV, beta-acetylglucosaminyltransferase IV, EC 2.4.1.51, GlcNAcTase-IV, GnT IV, GnT-IV, GnT-IVa, GnT-IVb, GnTIVa, Mgat4a, Mgat4b, N-acetylglucosaminyltransferase IV, N-acetylglucosaminyltransferase IVa, N-acetylglucosaminyltransferase-IV, N-acetylglucosaminyltransferase-IVa, N-acetylglucosaminyltransferase-IVb, N-glycosyl-oligosaccharide-glycoprotein N-acetylglucosaminyltransferase IV, uridine diphosphoacetylglucosamine-glycopeptide beta4-acetylglucosaminyltransferase IV
ECTree
Source Tissue
Source Tissue on EC 2.4.1.145 - alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase
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low activity
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high activity
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high activity
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low activity
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isoform GnT-IVa is highly restricted in gastrointestinal organs and peripheral blood leukocytes
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low activity
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high expression of GnT-IVa, profiles and structures of the cell-surface N-glycan of hepatocellular carcinoma cells, high levels of NA3Fb, a core-alpha-1,6-fucosylated triantennary glycan, overview
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low activity
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low activity
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isoform GnT-IVa is highly restricted in gastrointestinal organs and peripheral blood leukocytes
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high activity
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high activity
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in epirubicin-resistant HLE cells, GnT-IVa expression is decreased
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in epirubicin-resistant HLE cells, GnT-IVb expression is increased
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low activity
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Panc-1, PCI6, MIA PaCa-2, and BxPC3. Down-regulation of GnT-IVa in pancreatic cancer cells is due to an epigenetic abnormality in the gene. When pancreatic cancer cells are treated with 5-aza-C or butyrate, the expression of GnT-IVa is dramatically increased
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Panc-1, PCI6, MIA PaCa-2, and BxPC3. Expression of GnT-IVb is increased in pancreatic cancer, compared to normal pancreatic tissues
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additional information
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three choriocarcinoma cell lines
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additional information
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isoform GnT-IVb is ubiquitously and constitutively expressed among tissues
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additional information
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in wild type mice, GnT-IVa expression is restricted to gastrointestinal tissues, whereas GnT-IVb is broadly expressed among organs
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