2.4.1.147: acetylgalactosaminyl-O-glycosyl-glycoprotein beta-1,3-N-acetylglucosaminyltransferase

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For detailed information about acetylgalactosaminyl-O-glycosyl-glycoprotein beta-1,3-N-acetylglucosaminyltransferase, go to the full flat file.

Reaction

Synonyms

acetylglucosaminyltransferase, uridine diphosphoacetylglucosamine-mucin beta(1-3)-, B3GNT6, beta3-N-acetylglucosaminyltransferase-6, beta3Gn-T6, beta3GnT-6, C3 beta3GnT6, C3GnT, core 3 beta 1,3-N-acetylglucosaminyltransferase, core 3 beta1,3-N-acetylglucosaminyltransferase, core 3 beta3-GlcNAc-T, core 3 beta3-N-acetylglucosaminyltransferase 6, core 3 synthase, core 3beta-GlcNAc-transferase, core3 O-glycan synthase, core3 synthase, mucin core 3 beta3-GlcNAc-transferase, O-glycosyl-oligosaccharide-glycoprotein N-acetylglucosaminyltransferase III, UDPGlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 6, uridine diphosphate, uridine diphosphoacetylglucosamine-mucin beta(1-3)-acetylglucosaminyltransferase, [UDP]-GlcNAc:betaGal beta1,3-N-acetylglucosaminyltransferase

ECTree

     2 Transferases

         2.4 Glycosyltransferases

             2.4.1 Hexosyltransferases

                2.4.1.147 acetylgalactosaminyl-O-glycosyl-glycoprotein beta-1,3-N-acetylglucosaminyltransferase

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Results	in table
6	Activating Compound
10	AA Sequence
1	Application
1	CAS Registry Number
5	Cloned(Commentary)
406	Disease/ Diagnostics
2	Expression
9	General Information
3	General Stability
12	Inhibitors
6	KM Value [mM]
13	Localization
3	Metals/Ions
2	Molecular Weight [Da]
9	Natural Substrates/ Products (Substrates)
25	Organism
3	Pathway
7	pH Optimum
1	Posttranslational Modification
5	Protein Variants
1	Purification (Commentary)
1	Reaction
1	Reaction Type
25	Reference
51	Source Tissue
3	Specific Activity [micromol/min/mg]
60	Substrates and Products (Substrate)
2	Subunits
31	Synonyms
1	Systematic Name
11	Temperature Optimum [°C]

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Cloned on EC 2.4.1.147 - acetylgalactosaminyl-O-glycosyl-glycoprotein beta-1,3-N-acetylglucosaminyltransferase

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CLONED (Commentary)

ORGANISM

UNIPROT

LITERATURE

expressed in PC3 and LNCaP prostate cancer cell lines

Homo sapiens

-

704495

expression in Spodoptera frugiperda Sf21 cells via baculovirus infection as soluble FLAG-tagged fusion protein

Homo sapiens

Q6ZMB0

638141

gene B3gnt6

Mus musculus

Q3USF0

736236

gene B3GNT6, recombinant expression in CHO-K1 cells. Glycosylation-related genes in CHO-K1 cells are present, but strictly suppressed and regulated. CHO cells are transiently co-transfected with plasmids encoding extended C1 beta3GnT3, C2 beta6GnT1, or C3 beta3GnT6 with or without ST6Gal I or CHST4, respectively, and resulting O-glycan and core chain spectrum, overview

Homo sapiens

Q6ZMB0

736540

gene B3GNT6, recombinant expression in Saccharomyces cerevisiae, the human beta3Gn-T6 is produced as a protein fused with the transmembrane domains of Saccharomyces cerevisiae glycosyltransferases (ScMnn9p, ScMnn2p, ScMnn1p, or ScGnt1p), thereby localizing beta3Gn-T6 to the Golgi, optimization of beta3Gn-T6 expression

Homo sapiens

Q6ZMB0

758840