2.4.1.147: acetylgalactosaminyl-O-glycosyl-glycoprotein beta-1,3-N-acetylglucosaminyltransferase

This is an abbreviated version!
For detailed information about acetylgalactosaminyl-O-glycosyl-glycoprotein beta-1,3-N-acetylglucosaminyltransferase, go to the full flat file.

Reaction

Synonyms

acetylglucosaminyltransferase, uridine diphosphoacetylglucosamine-mucin beta(1-3)-, B3GNT6, beta3-N-acetylglucosaminyltransferase-6, beta3Gn-T6, beta3GnT-6, C3 beta3GnT6, C3GnT, core 3 beta 1,3-N-acetylglucosaminyltransferase, core 3 beta1,3-N-acetylglucosaminyltransferase, core 3 beta3-GlcNAc-T, core 3 beta3-N-acetylglucosaminyltransferase 6, core 3 synthase, core 3beta-GlcNAc-transferase, core3 O-glycan synthase, core3 synthase, mucin core 3 beta3-GlcNAc-transferase, O-glycosyl-oligosaccharide-glycoprotein N-acetylglucosaminyltransferase III, UDPGlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 6, uridine diphosphate, uridine diphosphoacetylglucosamine-mucin beta(1-3)-acetylglucosaminyltransferase, [UDP]-GlcNAc:betaGal beta1,3-N-acetylglucosaminyltransferase

ECTree

     2 Transferases

         2.4 Glycosyltransferases

             2.4.1 Hexosyltransferases

                2.4.1.147 acetylgalactosaminyl-O-glycosyl-glycoprotein beta-1,3-N-acetylglucosaminyltransferase

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Results	in table
6	Activating Compound
10	AA Sequence
1	Application
1	CAS Registry Number
5	Cloned(Commentary)
406	Disease/ Diagnostics
2	Expression
9	General Information
3	General Stability
12	Inhibitors
6	KM Value [mM]
13	Localization
3	Metals/Ions
2	Molecular Weight [Da]
9	Natural Substrates/ Products (Substrates)
25	Organism
3	Pathway
7	pH Optimum
1	Posttranslational Modification
5	Protein Variants
1	Purification (Commentary)
1	Reaction
1	Reaction Type
25	Reference
51	Source Tissue
3	Specific Activity [micromol/min/mg]
60	Substrates and Products (Substrate)
2	Subunits
31	Synonyms
1	Systematic Name
11	Temperature Optimum [°C]

Natural Substrates Products

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Natural Substrates Products on EC 2.4.1.147 - acetylgalactosaminyl-O-glycosyl-glycoprotein beta-1,3-N-acetylglucosaminyltransferase

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NATURAL SUBSTRATE

NATURAL PRODUCT

REACTION DIAGRAM

ORGANISM

UNIPROT

COMMENTARY
(Substrate)

LITERATURE
(Substrate)

COMMENTARY
(Product)

LITERATURE
(Product)

REVERSIBILITY
r=reversible
ir=irreversible
?=not specified

UDP-N-acetyl-alpha-D-glucosamine + N-acetyl-alpha-D-galactosaminyl-Ser/Thr

UDP + N-acetyl-beta-D-glucosaminyl-(1->)3-N-acetyl-alpha-D-galactosaminyl-Ser/Thr

Homo sapiens

-

-

704495

-

-

?

UDP-N-acetyl-alpha-D-glucosamine + O3-[N-acetyl-alpha-D-galactosaminyl]-L-threonyl/L-seryl-[protein]

UDP + O3-[N-acetyl-beta-D-glucosaminyl-(1->3)-N-acetyl-alpha-D-galactosaminyl]-L-threonyl/L-seryl-[protein]

2 entries

UDP-N-acetyl-D-glucosamine + N-acetyl-beta-D-galactosaminyl-alpha-R

UDP + N-acetyl-beta-D-glucosaminyl-1,3-N-acetyl-beta-D-galactosaminyl-R

3 entries

additional information

?

-

2 entries

UDP-N-acetyl-alpha-D-glucosamine + O3-[N-acetyl-alpha-D-galactosaminyl]-L-threonyl/L-seryl-[protein]

UDP + O3-[N-acetyl-beta-D-glucosaminyl-(1->3)-N-acetyl-alpha-D-galactosaminyl]-L-threonyl/L-seryl-[protein]

Homo sapiens

Q6ZMB0

-

758840

-

-

?

UDP-N-acetyl-alpha-D-glucosamine + O3-[N-acetyl-alpha-D-galactosaminyl]-L-threonyl/L-seryl-[protein]

UDP + O3-[N-acetyl-beta-D-glucosaminyl-(1->3)-N-acetyl-alpha-D-galactosaminyl]-L-threonyl/L-seryl-[protein]

Mus musculus

Q3USF0

-

759814

-

-

?

UDP-N-acetyl-D-glucosamine + N-acetyl-beta-D-galactosaminyl-alpha-R

UDP + N-acetyl-beta-D-glucosaminyl-1,3-N-acetyl-beta-D-galactosaminyl-R

Homo sapiens

Q6ZMB0

R: polypeptide derived from mucin, involved in mucin oligosaccharide biosynthesis

638141

-

-

?

UDP-N-acetyl-D-glucosamine + N-acetyl-beta-D-galactosaminyl-alpha-R

UDP + N-acetyl-beta-D-glucosaminyl-1,3-N-acetyl-beta-D-galactosaminyl-R

Homo sapiens

Q6ZMB0

important role in synthesis of mucin-type O-glycans in digestive organs

638141

-

-

?

UDP-N-acetyl-D-glucosamine + N-acetyl-beta-D-galactosaminyl-alpha-R

UDP + N-acetyl-beta-D-glucosaminyl-1,3-N-acetyl-beta-D-galactosaminyl-R

Rattus norvegicus

-

R: polypeptide derived from mucin, involved in mucin oligosaccharide biosynthesis

488370, 638138

-

-

?

additional information

?

-

Homo sapiens

-

expression of the enzyme is closely regulated during differentiation and dedifferentiation. Rge expression of the enzyme dramatically decreased in cancerous tissues, and the changes to the core structures of O-glycans give rise to phenotypic changes of cancer cells, such as mobility and metastatic activity

660389

-

-

?

additional information

?

-

Mus musculus

-

C3GnT-deficient mice display a discrete, colonspecific reduction in Muc2 protein and increased permeability of the intestinal barrier. These mice are highly susceptible to experimental triggers of colitis and colorectal adenocarcinoma

688103

-

-

?