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2.4.1.148: acetylgalactosaminyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase

This is an abbreviated version!
For detailed information about acetylgalactosaminyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase, go to the full flat file.

Reaction

UDP-N-acetyl-D-glucosamine
+
N-acetyl-beta-D-glucosaminyl-(1->3)-N-acetyl-D-galactosaminyl-R
=
UDP
+
N-acetyl-beta-D-glucosaminyl-(1->6)-[N-acetyl-beta-D-glucosaminyl-(1->3)]-N-acetyl-D-galactosaminyl-R

Synonyms

acetylglucosaminyltransferase, uridine diphosphoacetylglucosamine-mucin beta(1-->6)-, B, bC2GnT-M, C2GnT, C2GnT-2, C2GnT-I, C2GnT-L, c2GnT-M, C2GnT1, C2GnT2, C2GnT3, core 2 beta 1,6 N-acetylglucosaminyltransferase, core 2 beta-1,6-N-acetylglucosaminyltransferase, core 2 beta-1,6-N-acetylglucosaminyltransferase-M, core 2 beta1,6-N-acetylglucosaminyltransferase, core 2 beta6 GlcNAc-transferase, core 2 N-acetylglucosaminyltransferase-M, core 2 _1,6 N-acetylglucosaminyltransferase mucus-type, core 4 beta6-GalNAc-transferase, core 6beta-GalNAc-transferase B, leukocyte-type core 2 beta1,6-N-acetylglucosaminyltransferase, More, mucin-type core 2 beta-1,6-N-acetylglucosaminyltransferase-M, mucin-type core 2 beta-6-GlcNAc-transferase, O-glycosyl-oligosaccharide-glycoprotein N-acetylglucosaminyltransferase IV, uridine diphosphoacetylglucosamine-mucin beta(1-->6)-acetylglucosaminyltransferase B

ECTree

     2 Transferases
         2.4 Glycosyltransferases
             2.4.1 Hexosyltransferases
                2.4.1.148 acetylgalactosaminyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase

Reference

Reference on EC 2.4.1.148 - acetylgalactosaminyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase

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REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Schachter, H.; Brockhausen, I.; Hull, E.
High-performance liquid chromatography assays for N-acetylglucosaminyltransferases involved in N- and O-glycan synthesis
Methods Enzymol.
179
351-397
1989
Canis lupus familiaris, Ovis aries, Homo sapiens, Platyrrhini, Rattus norvegicus, Sus scrofa
Manually annotated by BRENDA team
Brockhausen, I.; Rachaman, E.S.; Matta, K.L.; Schachter, H.
The separation by liquid chromatography (under elevated pressure) of phenyl, benzyl, and O-nitrophenyl glycosides of oligosaccharides. Analysis of substrates and products for four N-acetyl-D-glucosaminyl-transferases involved in mucin synthesis
Carbohydr. Res.
120
3-16
1983
Rattus norvegicus
Manually annotated by BRENDA team
Brockhausen, I.; Matta, K.L.; Orr, J.; Schachter, H.
Mucin synthesis. UDP-GlcNAc:GalNAc-R beta 3-N-acetylglucosaminyltransferase and UDP-GlcNAc:GlcNAc beta 1-3GalNAc-R (GlcNAc to GalNAc) beta 6-N-acetylglucosaminyltransferase from pig and rat colon mucosa
Biochemistry
24
1866-1874
1985
Canis lupus familiaris, Ovis aries, Homo sapiens, Platyrrhini, Rattus norvegicus, Sus scrofa
Manually annotated by BRENDA team
Zeng, S.; Dinter, A.; Eisenkratzer, D.; Biselli, M.; Wandrey, C.; Berger, E.G.
Pilot scale expression and purification of soluble protein A tagged beta1,6N-acetylglucosaminyltransferase in CHO cells
Biochem. Biophys. Res. Commun.
237
653-658
1997
Mus musculus
Manually annotated by BRENDA team
Vanderplasschen, A.; Markine-Goriaynoff, N.; Lomonte, P.; Suzuki, M.; Hiraoka, N.; Yeh, J.C.; Bureau, F.; Willems, L.; Thiry, E.; Fukuda, M.; Pastoret, P.P.
A multipotential beta-1,6-N-acetylglucosaminyltransferase is encoded by bovine herpesvirus type 4
Proc. Natl. Acad. Sci. USA
97
5756-5761
2000
Bovine gammaherpesvirus 4 (Q9IZK2)
Manually annotated by BRENDA team
Beum, P.V.; Basma, H.; Bastola, D.R.; Cheng, P.W.
Mucin biosynthesis: upregulation of core 2 beta 1,6 N-acetylglucosaminyltransferase by retinoic acid and Th2 cytokines in a human airway epithelial cell line
Am. J. Physiol.
288
L116-124
2005
Homo sapiens
Manually annotated by BRENDA team
Singh, J.; Khan, G.A.; Kinarsky, L.; Cheng, H.; Wilken, J.; Choi, K.H.; Bedows, E.; Sherman, S.; Cheng, P.W.
Identification of disulfide bonds among the nine core 2 N-acetylglucosaminyltransferase-M cysteines conserved in the mucin beta6-N-acetylglucosaminyltransferase family
J. Biol. Chem.
279
38969-38977
2004
Bos taurus
Manually annotated by BRENDA team
McBride, D.S.; Brockhausen, I.; Kan, F.W.K.
Detection of glycosyltransferases in the golden hamster (Mesocricetus auratus) oviduct and evidence for the regulation of O-glycan biosynthesis during the estrous cycle
Biochim. Biophys. Acta
1721
107-115
2005
Mesocricetus auratus
Manually annotated by BRENDA team
Markine-Goriaynoff, N.; Gillet, L.; Karlsen, O.A.; Haarr, L.; Minner, F.; Pastoret, P.P.; Fukuda, M.; Vanderplasschen, A.
The core 2 beta-1,6-N-acetylglucosaminyltransferase-M encoded by bovine herpesvirus 4 is not essential for virus replication despite contributing to post-translational modifications of structural proteins
J. Gen. Virol.
85
355-367
2004
Bovine gammaherpesvirus 4
Manually annotated by BRENDA team
Ismail, M.N.; Stone, E.L.; Panico, M.; Lee, S.H.; Luu, Y.; Ramirez, K.; Ho, S.B.; Fukuda, M.; Marth, J.D.; Haslam, S.M.; Dell, A.
High-sensitivity O-glycomic analysis of mice deficient in core 2 beta1,6-N-acetylglucosaminyltransferases
Glycobiology
21
82-98
2011
Mus musculus
Manually annotated by BRENDA team
Petrosyan, A.; Ali, M.F.; Verma, S.K.; Cheng, H.; Cheng, P.W.
Non-muscle myosin IIA transports a Golgi glycosyltransferase to the endoplasmic reticulum by binding to its cytoplasmic tail
Int. J. Biochem. Cell Biol.
44
1153-1165
2012
Homo sapiens
Manually annotated by BRENDA team
Suzuki, Y.; Sutoh, M.; Hatakeyama, S.; Mori, K.; Yamamoto, H.; Koie, T.; Saitoh, H.; Yamaya, K.; Funyu, T.; Habuchi, T.; Arai, Y.; Fukuda, M.; Ohyama, C.; Tsuboi, S.
MUC1 carrying core 2 O-glycans functions as a molecular shield against NK cell attack, promoting bladder tumor metastasis
Int. J. Oncol.
40
1831-1838
2012
Homo sapiens
Manually annotated by BRENDA team
Pak, J.E.; Satkunarajah, M.; Seetharaman, J.; Rini, J.M.
Structural and mechanistic characterization of leukocyte-type core 2 ?1,6-N-acetylglucosaminyltransferase: a metal-ion-independent GT-A glycosyltransferase
J. Mol. Biol.
414
798-811
2011
Mus musculus
Manually annotated by BRENDA team