2.4.1.15: alpha,alpha-trehalose-phosphate synthase (UDP-forming)

This is an abbreviated version!
For detailed information about alpha,alpha-trehalose-phosphate synthase (UDP-forming), go to the full flat file.

Reaction

Synonyms

alpha,alpha-trehalose phosphate synthase (UDP-forming), alpha,alpha-trehalose-phosphate synthase (UDP-forming), AtTPS1, AtTPS6, GbTPS, glucosyltransferase, uridine diphosphoglucose phosphate, OtsA, OtsA1, OtsA2, phosphotrehalose-uridine diphosphate transglucosylase, T-6-P, T6P synthase, Ta1210, TPS, TPS-2, TPS-3, TPS1, TPS2, TPS3, TPS5, TPSP, transglucosylase, trehalose 6-phosphate synthase, trehalose 6-phosphate synthase 1, trehalose 6-phosphate synthetase, trehalose phosphate synthase, trehalose phosphate synthase 5, trehalose phosphate synthetase, trehalose phosphate-uridine diphosphate glucosyltransferase, trehalose-6-P synthase, trehalose-6-phosphate synthase, trehalose-6-phosphate synthase 1, trehalose-6-phosphate synthase/phosphatase, trehalose-6P synthase, trehalose-P synthetase, trehalosephosphate-UDP glucosyl transferase, UDP-glucose:D-glucose-6-phosphate 1-alpha-D-glucosyltransferase, UDPglucose-glucose-phosphate glucosyltransferase

ECTree

     2 Transferases

         2.4 Glycosyltransferases

             2.4.1 Hexosyltransferases

                2.4.1.15 alpha,alpha-trehalose-phosphate synthase (UDP-forming)

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Results	in table
52	Activating Compound
8087	AA Sequence
7	Application
1	CAS Registry Number
56	Cloned(Commentary)
7	Crystallization (Commentary)
12	Expression
49	General Information
5	General Stability
62	IC50 Value
153	Inhibitors
1	kcat/KM [mM/s]
2	Ki Value [mM]
49	KM Value [mM]
4	Localization
70	Metals/Ions
32	Molecular Weight [Da]
74	Natural Substrates/ Products (Substrates)
4	Organic Solvent Stability
124	Organism
6	Pathway
70	PDB ID
25	pH Optimum
9	pH Range
7	pH Stability
10	pI Value
4	Posttranslational Modification
30	Protein Variants
32	Purification (Commentary)
4	Reaction
7	Reaction Type
121	Reference
61	Source Tissue
42	Specific Activity [micromol/min/mg]
9	Storage Stability
199	Substrates and Products (Substrate)
45	Subunits
185	Synonyms
1	Systematic Name
24	Temperature Optimum [°C]
9	Temperature Range [°C]
9	Temperature Stability [°C]
7	Turnover Number [1/s]

IC50 Value

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IC50 Value on EC 2.4.1.15 - alpha,alpha-trehalose-phosphate synthase (UDP-forming)

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IC50 VALUE [mM]

INHIBITOR

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

IMAGE

0.1

2,6-diamino-4-(2,4-dichlorophenyl)-4H-thiopyran-3,5-dicarbonitrile

2 entries

0.1

2,6-diamino-4-(2-methylphenyl)-4H-thiopyran-3,5-dicarbonitrile

2 entries

0.0002 - 0.0005

2,6-diamino-4-(3,4-dichlorophenyl)-4H-thiopyran-3,5-dicarbonitrile

2 entries

0.0012 - 0.0017

2,6-diamino-4-(3-bromophenyl)-4H-thiopyran-3,5-dicarbonitrile

2 entries

0.0012 - 0.0013

2,6-diamino-4-(3-chlorophenyl)-4H-thiopyran-3,5-dicarbonitrile

2 entries

0.005 - 0.0061

2,6-diamino-4-(3-fluorophenyl)-4H-thiopyran-3,5-dicarbonitrile

2 entries

0.0026 - 0.0049

2,6-diamino-4-(3-iodophenyl)-4H-thiopyran-3,5-dicarbonitrile

2 entries

0.0918 - 0.1

2,6-diamino-4-(4,5-dihydrofuran-3-yl)-4H-thiopyran-3,5-dicarbonitrile

2 entries

0.0631 - 0.1

2,6-diamino-4-(4,5-dihydrothiophen-3-yl)-4H-thiopyran-3,5-dicarbonitrile

2 entries

0.1

2,6-diamino-4-(4-bromo-5-ethylthiophen-2-yl)-4H-thiopyran-3,5-dicarbonitrile

2 entries

0.0008 - 0.1

2,6-diamino-4-(4-bromo-5-methylthiophen-2-yl)-4H-thiopyran-3,5-dicarbonitrile

2 entries

0.004 - 0.011

2,6-diamino-4-(4-bromothiophen-2-yl)-4H-thiopyran-3,5-dicarbonitrile

2 entries

0.0045 - 0.0149

2,6-diamino-4-(4-chlorophenyl)-4H-thiopyran-3,5-dicarbonitrile

2 entries

0.0129 - 0.0758

2,6-diamino-4-(4-methylphenyl)-4H-thiopyran-3,5-dicarbonitrile

2 entries

0.0287 - 0.0419

2,6-diamino-4-(4-nitrophenyl)-4H-thiopyran-3,5-dicarbonitrile

2 entries

0.0045 - 0.023

2,6-diamino-4-(5-bromothiophen-2-yl)-4H-thiopyran-3,5-dicarbonitrile

2 entries

0.0059 - 0.0173

2,6-diamino-4-(5-chlorothiophen-2-yl)-4H-thiopyran-3,5-dicarbonitrile

2 entries

0.0665 - 0.1

2,6-diamino-4-(5-ethylthiophen-2-yl)-4H-thiopyran-3,5-dicarbonitrile

2 entries

0.0054 - 0.0061

2,6-diamino-4-(5-nitrothiophen-2-yl)-4H-thiopyran-3,5-dicarbonitrile

2 entries

0.0026 - 0.0029

2,6-diamino-4-(cyclohex-2-en-1-yl)-4H-thiopyran-3,5-dicarbonitrile

2 entries

0.0031 - 0.0046

2,6-diamino-4-(cyclohex-3-en-1-yl)-4H-thiopyran-3,5-dicarbonitrile

2 entries

0.0014 - 0.0019

2,6-diamino-4-cyclohexyl-4H-thiopyran-3,5-dicarbonitrile

2 entries

0.1 - 789

2,6-diamino-4-phenyl-4H-thiopyran-3,5-dicarbonitrile

2 entries

0.00371 - 0.00505

2,6-diamino-4-[3-(trifluoromethyl)phenyl]-4H-thiopyran-3,5-dicarbonitrile

2 entries

0.1

2,6-diamino-4-[4-(trifluoromethyl)phenyl]-4H-thiopyran-3,5-dicarbonitrile

2 entries

0.0014 - 0.0046

3-amino-4-formyl-2-[2-oxo-2-(tricyclo[3.3.1.13,7]dec-1-yl)ethyl]cyclopent-3-ene-1,1,2-tricarbonitrile

2 entries

0.1

6-amino-4-(3,4-dichlorophenyl)-2-thioxo-1,2,3,4-tetrahydropyridine-3,5-dicarbonitrile

2 entries

0.0062 - 0.0066

8-chloro-11-(piperazin-1-yl)-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridine

2 entries

0.0086 - 0.0314

8-hydroxy-2,4-dimethyl-7H-chromen-7-one

2 entries

0.0094 - 0.0147

methyl 2-chloro-5-(5-[(Z)-[3-(2,4-dimethylphenyl)-4-oxo-2-thioxo-1,3-thiazolidin-5-ylidene]methyl]furan-2-yl)benzoate

2 entries

0.0028 - 0.0055

O,O-diphenyl [(2E)-2-[2-(2-chlorophenyl)hydrazinylidene]-2-cyanoethanethioyl]phosphoramidothioate

2 entries

0.1

2,6-diamino-4-(2,4-dichlorophenyl)-4H-thiopyran-3,5-dicarbonitrile

Drosophila melanogaster

Q9Y119

2 mM phosphoenol pyruvate, 2% (w/v) NaCl, 0.5% (w/v) KCl, 10 mM MgCl2, 1 mM dithiothreitol, 1.5 U/ml pyruvate kinase, pH 7.5 22 °C

719600

0.1

2,6-diamino-4-(2,4-dichlorophenyl)-4H-thiopyran-3,5-dicarbonitrile

Ctenocephalides felis

J7G8S5

2 mM phosphoenol pyruvate, 2% (w/v) NaCl, 0.5% (w/v) KCl, 10 mM MgCl2, 1 mM dithiothreitol, 1.5 U/ml pyruvate kinase, pH 7.5 22 °C

719600

0.1

2,6-diamino-4-(2-methylphenyl)-4H-thiopyran-3,5-dicarbonitrile

Drosophila melanogaster

Q9Y119

2 mM phosphoenol pyruvate, 2% (w/v) NaCl, 0.5% (w/v) KCl, 10 mM MgCl2, 1 mM dithiothreitol, 1.5 U/ml pyruvate kinase, pH 7.5 22 °C

719600

0.1

2,6-diamino-4-(2-methylphenyl)-4H-thiopyran-3,5-dicarbonitrile

Ctenocephalides felis

J7G8S5

2 mM phosphoenol pyruvate, 2% (w/v) NaCl, 0.5% (w/v) KCl, 10 mM MgCl2, 1 mM dithiothreitol, 1.5 U/ml pyruvate kinase, pH 7.5 22 °C

719600

0.0002

2,6-diamino-4-(3,4-dichlorophenyl)-4H-thiopyran-3,5-dicarbonitrile

Drosophila melanogaster

Q9Y119

2 mM phosphoenol pyruvate, 2% (w/v) NaCl, 0.5% (w/v) KCl, 10 mM MgCl2, 1 mM dithiothreitol, 1.5 U/ml pyruvate kinase, pH 7.5 22 °C

719600

0.0005

2,6-diamino-4-(3,4-dichlorophenyl)-4H-thiopyran-3,5-dicarbonitrile

Ctenocephalides felis

J7G8S5

2 mM phosphoenol pyruvate, 2% (w/v) NaCl, 0.5% (w/v) KCl, 10 mM MgCl2, 1 mM dithiothreitol, 1.5 U/ml pyruvate kinase, pH 7.5 22 °C

719600

0.0012

2,6-diamino-4-(3-bromophenyl)-4H-thiopyran-3,5-dicarbonitrile

Drosophila melanogaster

Q9Y119

2 mM phosphoenol pyruvate, 2% (w/v) NaCl, 0.5% (w/v) KCl, 10 mM MgCl2, 1 mM dithiothreitol, 1.5 U/ml pyruvate kinase, pH 7.5 22 °C

719600

0.0017

2,6-diamino-4-(3-bromophenyl)-4H-thiopyran-3,5-dicarbonitrile

Ctenocephalides felis

J7G8S5

2 mM phosphoenol pyruvate, 2% (w/v) NaCl, 0.5% (w/v) KCl, 10 mM MgCl2, 1 mM dithiothreitol, 1.5 U/ml pyruvate kinase, pH 7.5 22 °C

719600

0.0012

2,6-diamino-4-(3-chlorophenyl)-4H-thiopyran-3,5-dicarbonitrile

Drosophila melanogaster

Q9Y119

2 mM phosphoenol pyruvate, 2% (w/v) NaCl, 0.5% (w/v) KCl, 10 mM MgCl2, 1 mM dithiothreitol, 1.5 U/ml pyruvate kinase, pH 7.5 22 °C

719600

0.0013

2,6-diamino-4-(3-chlorophenyl)-4H-thiopyran-3,5-dicarbonitrile

Ctenocephalides felis

J7G8S5

2 mM phosphoenol pyruvate, 2% (w/v) NaCl, 0.5% (w/v) KCl, 10 mM MgCl2, 1 mM dithiothreitol, 1.5 U/ml pyruvate kinase, pH 7.5 22 °C

719600

0.005

2,6-diamino-4-(3-fluorophenyl)-4H-thiopyran-3,5-dicarbonitrile

Drosophila melanogaster

Q9Y119

2 mM phosphoenol pyruvate, 2% (w/v) NaCl, 0.5% (w/v) KCl, 10 mM MgCl2, 1 mM dithiothreitol, 1.5 U/ml pyruvate kinase, pH 7.5 22 °C

719600

0.0061

2,6-diamino-4-(3-fluorophenyl)-4H-thiopyran-3,5-dicarbonitrile

Ctenocephalides felis

J7G8S5

2 mM phosphoenol pyruvate, 2% (w/v) NaCl, 0.5% (w/v) KCl, 10 mM MgCl2, 1 mM dithiothreitol, 1.5 U/ml pyruvate kinase, pH 7.5 22 °C

719600

0.0026

2,6-diamino-4-(3-iodophenyl)-4H-thiopyran-3,5-dicarbonitrile

Drosophila melanogaster

Q9Y119

2 mM phosphoenol pyruvate, 2% (w/v) NaCl, 0.5% (w/v) KCl, 10 mM MgCl2, 1 mM dithiothreitol, 1.5 U/ml pyruvate kinase, pH 7.5 22 °C

719600

0.0049

2,6-diamino-4-(3-iodophenyl)-4H-thiopyran-3,5-dicarbonitrile

Ctenocephalides felis

J7G8S5

2 mM phosphoenol pyruvate, 2% (w/v) NaCl, 0.5% (w/v) KCl, 10 mM MgCl2, 1 mM dithiothreitol, 1.5 U/ml pyruvate kinase, pH 7.5 22 °C

719600

0.0918

2,6-diamino-4-(4,5-dihydrofuran-3-yl)-4H-thiopyran-3,5-dicarbonitrile

Ctenocephalides felis

J7G8S5

2 mM phosphoenol pyruvate, 2% (w/v) NaCl, 0.5% (w/v) KCl, 10 mM MgCl2, 1 mM dithiothreitol, 1.5 U/ml pyruvate kinase, pH 7.5 22 °C

719600

0.1

2,6-diamino-4-(4,5-dihydrofuran-3-yl)-4H-thiopyran-3,5-dicarbonitrile

Drosophila melanogaster

Q9Y119

2 mM phosphoenol pyruvate, 2% (w/v) NaCl, 0.5% (w/v) KCl, 10 mM MgCl2, 1 mM dithiothreitol, 1.5 U/ml pyruvate kinase, pH 7.5 22 °C

719600

0.0631

2,6-diamino-4-(4,5-dihydrothiophen-3-yl)-4H-thiopyran-3,5-dicarbonitrile

Drosophila melanogaster

Q9Y119

2 mM phosphoenol pyruvate, 2% (w/v) NaCl, 0.5% (w/v) KCl, 10 mM MgCl2, 1 mM dithiothreitol, 1.5 U/ml pyruvate kinase, pH 7.5 22 °C

719600

0.1

2,6-diamino-4-(4,5-dihydrothiophen-3-yl)-4H-thiopyran-3,5-dicarbonitrile

Ctenocephalides felis

J7G8S5

2 mM phosphoenol pyruvate, 2% (w/v) NaCl, 0.5% (w/v) KCl, 10 mM MgCl2, 1 mM dithiothreitol, 1.5 U/ml pyruvate kinase, pH 7.5 22 °C

719600

0.1

2,6-diamino-4-(4-bromo-5-ethylthiophen-2-yl)-4H-thiopyran-3,5-dicarbonitrile

Drosophila melanogaster

Q9Y119

2 mM phosphoenol pyruvate, 2% (w/v) NaCl, 0.5% (w/v) KCl, 10 mM MgCl2, 1 mM dithiothreitol, 1.5 U/ml pyruvate kinase, pH 7.5 22 °C

719600

0.1

2,6-diamino-4-(4-bromo-5-ethylthiophen-2-yl)-4H-thiopyran-3,5-dicarbonitrile

Ctenocephalides felis

J7G8S5

2 mM phosphoenol pyruvate, 2% (w/v) NaCl, 0.5% (w/v) KCl, 10 mM MgCl2, 1 mM dithiothreitol, 1.5 U/ml pyruvate kinase, pH 7.5 22 °C

719600

0.0008

2,6-diamino-4-(4-bromo-5-methylthiophen-2-yl)-4H-thiopyran-3,5-dicarbonitrile

Drosophila melanogaster

Q9Y119

2 mM phosphoenol pyruvate, 2% (w/v) NaCl, 0.5% (w/v) KCl, 10 mM MgCl2, 1 mM dithiothreitol, 1.5 U/ml pyruvate kinase, pH 7.5 22 °C

719600

0.1

2,6-diamino-4-(4-bromo-5-methylthiophen-2-yl)-4H-thiopyran-3,5-dicarbonitrile

Ctenocephalides felis

J7G8S5

2 mM phosphoenol pyruvate, 2% (w/v) NaCl, 0.5% (w/v) KCl, 10 mM MgCl2, 1 mM dithiothreitol, 1.5 U/ml pyruvate kinase, pH 7.5 22 °C

719600

0.004

2,6-diamino-4-(4-bromothiophen-2-yl)-4H-thiopyran-3,5-dicarbonitrile

Drosophila melanogaster

Q9Y119

2 mM phosphoenol pyruvate, 2% (w/v) NaCl, 0.5% (w/v) KCl, 10 mM MgCl2, 1 mM dithiothreitol, 1.5 U/ml pyruvate kinase, pH 7.5 22 °C

719600

0.011

2,6-diamino-4-(4-bromothiophen-2-yl)-4H-thiopyran-3,5-dicarbonitrile

Ctenocephalides felis

J7G8S5

2 mM phosphoenol pyruvate, 2% (w/v) NaCl, 0.5% (w/v) KCl, 10 mM MgCl2, 1 mM dithiothreitol, 1.5 U/ml pyruvate kinase, pH 7.5 22 °C

719600

0.0045

2,6-diamino-4-(4-chlorophenyl)-4H-thiopyran-3,5-dicarbonitrile

Drosophila melanogaster

Q9Y119

2 mM phosphoenol pyruvate, 2% (w/v) NaCl, 0.5% (w/v) KCl, 10 mM MgCl2, 1 mM dithiothreitol, 1.5 U/ml pyruvate kinase, pH 7.5 22 °C

719600

0.0149

2,6-diamino-4-(4-chlorophenyl)-4H-thiopyran-3,5-dicarbonitrile

Ctenocephalides felis

J7G8S5

2 mM phosphoenol pyruvate, 2% (w/v) NaCl, 0.5% (w/v) KCl, 10 mM MgCl2, 1 mM dithiothreitol, 1.5 U/ml pyruvate kinase, pH 7.5 22 °C

719600

0.0129

2,6-diamino-4-(4-methylphenyl)-4H-thiopyran-3,5-dicarbonitrile

Drosophila melanogaster

Q9Y119

2 mM phosphoenol pyruvate, 2% (w/v) NaCl, 0.5% (w/v) KCl, 10 mM MgCl2, 1 mM dithiothreitol, 1.5 U/ml pyruvate kinase, pH 7.5 22 °C

719600

0.0758

2,6-diamino-4-(4-methylphenyl)-4H-thiopyran-3,5-dicarbonitrile

Ctenocephalides felis

J7G8S5

2 mM phosphoenol pyruvate, 2% (w/v) NaCl, 0.5% (w/v) KCl, 10 mM MgCl2, 1 mM dithiothreitol, 1.5 U/ml pyruvate kinase, pH 7.5 22 °C

719600

0.0287

2,6-diamino-4-(4-nitrophenyl)-4H-thiopyran-3,5-dicarbonitrile

Drosophila melanogaster

Q9Y119

2 mM phosphoenol pyruvate, 2% (w/v) NaCl, 0.5% (w/v) KCl, 10 mM MgCl2, 1 mM dithiothreitol, 1.5 U/ml pyruvate kinase, pH 7.5 22 °C

719600

0.0419

2,6-diamino-4-(4-nitrophenyl)-4H-thiopyran-3,5-dicarbonitrile

Ctenocephalides felis

J7G8S5

2 mM phosphoenol pyruvate, 2% (w/v) NaCl, 0.5% (w/v) KCl, 10 mM MgCl2, 1 mM dithiothreitol, 1.5 U/ml pyruvate kinase, pH 7.5 22 °C

719600

0.0045

2,6-diamino-4-(5-bromothiophen-2-yl)-4H-thiopyran-3,5-dicarbonitrile

Drosophila melanogaster

Q9Y119

2 mM phosphoenol pyruvate, 2% (w/v) NaCl, 0.5% (w/v) KCl, 10 mM MgCl2, 1 mM dithiothreitol, 1.5 U/ml pyruvate kinase, pH 7.5 22 °C

719600

0.023

2,6-diamino-4-(5-bromothiophen-2-yl)-4H-thiopyran-3,5-dicarbonitrile

Ctenocephalides felis

J7G8S5

2 mM phosphoenol pyruvate, 2% (w/v) NaCl, 0.5% (w/v) KCl, 10 mM MgCl2, 1 mM dithiothreitol, 1.5 U/ml pyruvate kinase, pH 7.5 22 °C

719600

0.0059

2,6-diamino-4-(5-chlorothiophen-2-yl)-4H-thiopyran-3,5-dicarbonitrile

Drosophila melanogaster

Q9Y119

2 mM phosphoenol pyruvate, 2% (w/v) NaCl, 0.5% (w/v) KCl, 10 mM MgCl2, 1 mM dithiothreitol, 1.5 U/ml pyruvate kinase, pH 7.5 22 °C

719600

0.0173

2,6-diamino-4-(5-chlorothiophen-2-yl)-4H-thiopyran-3,5-dicarbonitrile

Ctenocephalides felis

J7G8S5

2 mM phosphoenol pyruvate, 2% (w/v) NaCl, 0.5% (w/v) KCl, 10 mM MgCl2, 1 mM dithiothreitol, 1.5 U/ml pyruvate kinase, pH 7.5 22 °C

719600

0.0665

2,6-diamino-4-(5-ethylthiophen-2-yl)-4H-thiopyran-3,5-dicarbonitrile

Drosophila melanogaster

Q9Y119

2 mM phosphoenol pyruvate, 2% (w/v) NaCl, 0.5% (w/v) KCl, 10 mM MgCl2, 1 mM dithiothreitol, 1.5 U/ml pyruvate kinase, pH 7.5 22 °C

719600

0.1

2,6-diamino-4-(5-ethylthiophen-2-yl)-4H-thiopyran-3,5-dicarbonitrile

Ctenocephalides felis

J7G8S5

2 mM phosphoenol pyruvate, 2% (w/v) NaCl, 0.5% (w/v) KCl, 10 mM MgCl2, 1 mM dithiothreitol, 1.5 U/ml pyruvate kinase, pH 7.5 22 °C

719600

0.0054

2,6-diamino-4-(5-nitrothiophen-2-yl)-4H-thiopyran-3,5-dicarbonitrile

Drosophila melanogaster

Q9Y119

2 mM phosphoenol pyruvate, 2% (w/v) NaCl, 0.5% (w/v) KCl, 10 mM MgCl2, 1 mM dithiothreitol, 1.5 U/ml pyruvate kinase, pH 7.5 22 °C

719600

0.0061

2,6-diamino-4-(5-nitrothiophen-2-yl)-4H-thiopyran-3,5-dicarbonitrile

Ctenocephalides felis

J7G8S5

2 mM phosphoenol pyruvate, 2% (w/v) NaCl, 0.5% (w/v) KCl, 10 mM MgCl2, 1 mM dithiothreitol, 1.5 U/ml pyruvate kinase, pH 7.5 22 °C

719600

0.0026

2,6-diamino-4-(cyclohex-2-en-1-yl)-4H-thiopyran-3,5-dicarbonitrile

Ctenocephalides felis

J7G8S5

2 mM phosphoenol pyruvate, 2% (w/v) NaCl, 0.5% (w/v) KCl, 10 mM MgCl2, 1 mM dithiothreitol, 1.5 U/ml pyruvate kinase, pH 7.5 22 °C

719600

0.0029

2,6-diamino-4-(cyclohex-2-en-1-yl)-4H-thiopyran-3,5-dicarbonitrile

Drosophila melanogaster

Q9Y119

2 mM phosphoenol pyruvate, 2% (w/v) NaCl, 0.5% (w/v) KCl, 10 mM MgCl2, 1 mM dithiothreitol, 1.5 U/ml pyruvate kinase, pH 7.5 22 °C

719600

0.0031

2,6-diamino-4-(cyclohex-3-en-1-yl)-4H-thiopyran-3,5-dicarbonitrile

Ctenocephalides felis

J7G8S5

2 mM phosphoenol pyruvate, 2% (w/v) NaCl, 0.5% (w/v) KCl, 10 mM MgCl2, 1 mM dithiothreitol, 1.5 U/ml pyruvate kinase, pH 7.5 22 °C

719600

0.0046

2,6-diamino-4-(cyclohex-3-en-1-yl)-4H-thiopyran-3,5-dicarbonitrile

Drosophila melanogaster

Q9Y119

2 mM phosphoenol pyruvate, 2% (w/v) NaCl, 0.5% (w/v) KCl, 10 mM MgCl2, 1 mM dithiothreitol, 1.5 U/ml pyruvate kinase, pH 7.5 22 °C

719600

0.0014

2,6-diamino-4-cyclohexyl-4H-thiopyran-3,5-dicarbonitrile

Drosophila melanogaster

Q9Y119

2 mM phosphoenol pyruvate, 2% (w/v) NaCl, 0.5% (w/v) KCl, 10 mM MgCl2, 1 mM dithiothreitol, 1.5 U/ml pyruvate kinase, pH 7.5 22 °C

719600

0.0019

2,6-diamino-4-cyclohexyl-4H-thiopyran-3,5-dicarbonitrile

Ctenocephalides felis

J7G8S5

2 mM phosphoenol pyruvate, 2% (w/v) NaCl, 0.5% (w/v) KCl, 10 mM MgCl2, 1 mM dithiothreitol, 1.5 U/ml pyruvate kinase, pH 7.5 22 °C

719600

0.1

2,6-diamino-4-phenyl-4H-thiopyran-3,5-dicarbonitrile

Ctenocephalides felis

J7G8S5

2 mM phosphoenol pyruvate, 2% (w/v) NaCl, 0.5% (w/v) KCl, 10 mM MgCl2, 1 mM dithiothreitol, 1.5 U/ml pyruvate kinase, pH 7.5 22 °C

719600

789

2,6-diamino-4-phenyl-4H-thiopyran-3,5-dicarbonitrile

Drosophila melanogaster

Q9Y119

2 mM phosphoenol pyruvate, 2% (w/v) NaCl, 0.5% (w/v) KCl, 10 mM MgCl2, 1 mM dithiothreitol, 1.5 U/ml pyruvate kinase, pH 7.5 22 °C

719600

0.00371

2,6-diamino-4-[3-(trifluoromethyl)phenyl]-4H-thiopyran-3,5-dicarbonitrile

Drosophila melanogaster

Q9Y119

2 mM phosphoenol pyruvate, 2% (w/v) NaCl, 0.5% (w/v) KCl, 10 mM MgCl2, 1 mM dithiothreitol, 1.5 U/ml pyruvate kinase, pH 7.5 22 °C

719600

0.00505

2,6-diamino-4-[3-(trifluoromethyl)phenyl]-4H-thiopyran-3,5-dicarbonitrile

Ctenocephalides felis

J7G8S5

2 mM phosphoenol pyruvate, 2% (w/v) NaCl, 0.5% (w/v) KCl, 10 mM MgCl2, 1 mM dithiothreitol, 1.5 U/ml pyruvate kinase, pH 7.5 22 °C

719600

0.1

2,6-diamino-4-[4-(trifluoromethyl)phenyl]-4H-thiopyran-3,5-dicarbonitrile

Drosophila melanogaster

Q9Y119

2 mM phosphoenol pyruvate, 2% (w/v) NaCl, 0.5% (w/v) KCl, 10 mM MgCl2, 1 mM dithiothreitol, 1.5 U/ml pyruvate kinase, pH 7.5 22 °C

719600

0.1

2,6-diamino-4-[4-(trifluoromethyl)phenyl]-4H-thiopyran-3,5-dicarbonitrile

Ctenocephalides felis

J7G8S5

2 mM phosphoenol pyruvate, 2% (w/v) NaCl, 0.5% (w/v) KCl, 10 mM MgCl2, 1 mM dithiothreitol, 1.5 U/ml pyruvate kinase, pH 7.5 22 °C

719600

0.0014

3-amino-4-formyl-2-[2-oxo-2-(tricyclo[3.3.1.13,7]dec-1-yl)ethyl]cyclopent-3-ene-1,1,2-tricarbonitrile

Drosophila melanogaster

Q9Y119

2 mM phosphoenol pyruvate, 2% (w/v) NaCl, 0.5% (w/v) KCl, 10 mM MgCl2, 1 mM dithiothreitol, 1.5 U/ml pyruvate kinase, pH 7.5 22 °C

719600

0.0046

3-amino-4-formyl-2-[2-oxo-2-(tricyclo[3.3.1.13,7]dec-1-yl)ethyl]cyclopent-3-ene-1,1,2-tricarbonitrile

Ctenocephalides felis

J7G8S5

2 mM phosphoenol pyruvate, 2% (w/v) NaCl, 0.5% (w/v) KCl, 10 mM MgCl2, 1 mM dithiothreitol, 1.5 U/ml pyruvate kinase, pH 7.5 22 °C

719600

0.1

6-amino-4-(3,4-dichlorophenyl)-2-thioxo-1,2,3,4-tetrahydropyridine-3,5-dicarbonitrile

Drosophila melanogaster

Q9Y119

2 mM phosphoenol pyruvate, 2% (w/v) NaCl, 0.5% (w/v) KCl, 10 mM MgCl2, 1 mM dithiothreitol, 1.5 U/ml pyruvate kinase, pH 7.5 22 °C

719600

0.1

6-amino-4-(3,4-dichlorophenyl)-2-thioxo-1,2,3,4-tetrahydropyridine-3,5-dicarbonitrile

Ctenocephalides felis

J7G8S5

2 mM phosphoenol pyruvate, 2% (w/v) NaCl, 0.5% (w/v) KCl, 10 mM MgCl2, 1 mM dithiothreitol, 1.5 U/ml pyruvate kinase, pH 7.5 22 °C

719600

0.0062

8-chloro-11-(piperazin-1-yl)-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridine

Drosophila melanogaster

Q9Y119

2 mM phosphoenol pyruvate, 2% (w/v) NaCl, 0.5% (w/v) KCl, 10 mM MgCl2, 1 mM dithiothreitol, 1.5 U/ml pyruvate kinase, pH 7.5 22 °C

719600

0.0066

8-chloro-11-(piperazin-1-yl)-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridine

Ctenocephalides felis

J7G8S5

2 mM phosphoenol pyruvate, 2% (w/v) NaCl, 0.5% (w/v) KCl, 10 mM MgCl2, 1 mM dithiothreitol, 1.5 U/ml pyruvate kinase, pH 7.5 22 °C

719600

0.0086

8-hydroxy-2,4-dimethyl-7H-chromen-7-one

Drosophila melanogaster

Q9Y119

2 mM phosphoenol pyruvate, 2% (w/v) NaCl, 0.5% (w/v) KCl, 10 mM MgCl2, 1 mM dithiothreitol, 1.5 U/ml pyruvate kinase, pH 7.5 22 °C

719600

0.0314

8-hydroxy-2,4-dimethyl-7H-chromen-7-one

Ctenocephalides felis

J7G8S5

2 mM phosphoenol pyruvate, 2% (w/v) NaCl, 0.5% (w/v) KCl, 10 mM MgCl2, 1 mM dithiothreitol, 1.5 U/ml pyruvate kinase, pH 7.5 22 °C

719600

0.0094

methyl 2-chloro-5-(5-[(Z)-[3-(2,4-dimethylphenyl)-4-oxo-2-thioxo-1,3-thiazolidin-5-ylidene]methyl]furan-2-yl)benzoate

Drosophila melanogaster

Q9Y119

2 mM phosphoenol pyruvate, 2% (w/v) NaCl, 0.5% (w/v) KCl, 10 mM MgCl2, 1 mM dithiothreitol, 1.5 U/ml pyruvate kinase, pH 7.5 22 °C

719600

0.0147

methyl 2-chloro-5-(5-[(Z)-[3-(2,4-dimethylphenyl)-4-oxo-2-thioxo-1,3-thiazolidin-5-ylidene]methyl]furan-2-yl)benzoate

Ctenocephalides felis

J7G8S5

2 mM phosphoenol pyruvate, 2% (w/v) NaCl, 0.5% (w/v) KCl, 10 mM MgCl2, 1 mM dithiothreitol, 1.5 U/ml pyruvate kinase, pH 7.5 22 °C

719600

0.0028

O,O-diphenyl [(2E)-2-[2-(2-chlorophenyl)hydrazinylidene]-2-cyanoethanethioyl]phosphoramidothioate

Drosophila melanogaster

Q9Y119

2 mM phosphoenol pyruvate, 2% (w/v) NaCl, 0.5% (w/v) KCl, 10 mM MgCl2, 1 mM dithiothreitol, 1.5 U/ml pyruvate kinase, pH 7.5 22 °C

719600

0.0055

O,O-diphenyl [(2E)-2-[2-(2-chlorophenyl)hydrazinylidene]-2-cyanoethanethioyl]phosphoramidothioate

Ctenocephalides felis

J7G8S5

2 mM phosphoenol pyruvate, 2% (w/v) NaCl, 0.5% (w/v) KCl, 10 mM MgCl2, 1 mM dithiothreitol, 1.5 U/ml pyruvate kinase, pH 7.5 22 °C

719600