2.4.1.15: alpha,alpha-trehalose-phosphate synthase (UDP-forming)
This is an abbreviated version!
For detailed information about alpha,alpha-trehalose-phosphate synthase (UDP-forming), go to the full flat file.
Word Map on EC 2.4.1.15
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2.4.1.15
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trehalase
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disaccharide
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tpp
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desiccation
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thermotolerance
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resurrection
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udp-glc
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validamycin
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anhydrobiosis
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selaginella
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agriculture
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drug development
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medicine
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analysis
- 2.4.1.15
- trehalase
- disaccharide
- tpp
-
desiccation
-
thermotolerance
-
resurrection
- udp-glc
- validamycin
-
anhydrobiosis
- selaginella
- agriculture
- drug development
- medicine
- analysis
Reaction
Synonyms
alpha,alpha-trehalose phosphate synthase (UDP-forming), alpha,alpha-trehalose-phosphate synthase (UDP-forming), AtTPS1, AtTPS6, GbTPS, glucosyltransferase, uridine diphosphoglucose phosphate, OtsA, OtsA1, OtsA2, phosphotrehalose-uridine diphosphate transglucosylase, T-6-P, T6P synthase, Ta1210, TPS, TPS-2, TPS-3, TPS1, TPS2, TPS3, TPS5, TPSP, transglucosylase, trehalose 6-phosphate synthase, trehalose 6-phosphate synthase 1, trehalose 6-phosphate synthetase, trehalose phosphate synthase, trehalose phosphate synthase 5, trehalose phosphate synthetase, trehalose phosphate-uridine diphosphate glucosyltransferase, trehalose-6-P synthase, trehalose-6-phosphate synthase, trehalose-6-phosphate synthase 1, trehalose-6-phosphate synthase/phosphatase, trehalose-6P synthase, trehalose-P synthetase, trehalosephosphate-UDP glucosyl transferase, UDP-glucose:D-glucose-6-phosphate 1-alpha-D-glucosyltransferase, UDPglucose-glucose-phosphate glucosyltransferase
ECTree
2.4.1.15 alpha,alpha-trehalose-phosphate synthase (UDP-forming)Advanced search results
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results (Metals Ions
Metals Ions on EC 2.4.1.15 - alpha,alpha-trehalose-phosphate synthase (UDP-forming)
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METALS and IONS 
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
Ca2+
Co2+
Cu2+
Fe2+
K+
KCl
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upon an increase in the KCl concentration from 0 to 100 mM, the OtsA activity decreases by more than 40%, whereas it is not significantly affected when UDP or GDP-glucose is used as the substrate
Mg2+
Mn2+
NaCl
Ni2+
Zn2+
additional information
Co2+
the enzyme does not require divalent metal ions for catalysis, but Mg2+, Zn2+, Co2+ and Mn2+ can stimulate enzyme activity and maximal activation is found in the presence of Mg2+. 1.91fold activation by 10 mM Co2+
Mg2+
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most appropriate cation to activate enzyme activity as it increases the activity by 7851fold at 12.5 mM
Mg2+
the enzyme does not require divalent metal ions for catalysis, but Mg2+, Zn2+, Co2+ and Mn2+ can stimulate enzyme activity and maximal activation is found in the presence of Mg2+. 2.33fold activation ba 10 mM Mg2+
Mn2+
the enzyme does not require divalent metal ions for catalysis, but Mg2+, Zn2+, Co2+ and Mn2+ can stimulate enzyme activity and maximal activation is found in the presence of Mg2+. 1.16fold activation by 10 mM Mn2+
NaCl
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an increase in the concentration of NaCl from 0 to 100 mM leads to a decrease in the OtsA activity by more than 35% when ADP-glucose or TDP-glucose is the substrate. When UDP-glucose or GDP-glucose is used as substrate, the OtsA activity is increased by 10–30%
Zn2+
the enzyme does not require divalent metal ions for catalysis, but Mg2+, Zn2+, Co2+ and Mn2+ can stimulate enzyme activity and maximal activation is found in the presence of Mg2+. 2.26fold activation by 10 mM Zn2+
additional information
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no or poor effects by CoCl2, CaCl2, BaCl2, and FeSO4
additional information
heparin in assays has no effect on the activity of recombinant OtsA1-His10
additional information
heparin in assays has no effect on the activity of recombinant OtsA1-His10
additional information
the addition of monovalent metal ions Na+, K+ and Li+ has no effect on the enzyme activity
additional information
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the addition of monovalent metal ions Na+, K+ and Li+ has no effect on the enzyme activity
additional information
no requirement for divalent cations for activity
