2.4.1.150: N-acetyllactosaminide beta-1,6-N-acetylglucosaminyltransferase
This is an abbreviated version!
For detailed information about N-acetyllactosaminide beta-1,6-N-acetylglucosaminyltransferase, go to the full flat file.
Word Map on EC 2.4.1.150
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2.4.1.150
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cataract
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poly-n-acetyllactosamine
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cryaa
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n-acetyllactosamine
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polylactosamines
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glycan-binding
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diagnostics
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pharmacology
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medicine
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synthesis
- 2.4.1.150
- cataract
- poly-n-acetyllactosamine
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cryaa
- n-acetyllactosamine
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polylactosamines
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glycan-binding
- diagnostics
- pharmacology
- medicine
- synthesis
Reaction
Synonyms
2beta-1,6-acetylglucosaminyltransferase, acetylglucosaminyltransferase, uridine diphosphoacetylglucosamine-acetyllactosaminide beta1-->6-, beta1-6GnT, C2/4GnT, C24GNT, C2GnT, C2GnT2, C2GNTM, core 2 beta-1,6-N-acetylglucosaminyltransferase, core 2beta-1,6-acetylglucosaminyltransferase, dIHnT, distally acting I-branching beta1,6-N-acetylglucosaminyltransferase, EC 2.4.1.164, Galbeta1-->4GlcNAc-R beta1-->6 N-acetylglucosaminyltransferase, GCNT2, Gcnt2 gene product, gcnt3, glucosaminyl (N-acetyl) transferase 2, GNTM, I beta1,6-N-acetylglucosaminyltransferase, I N-acetylglucosaminyltransferase, I-branching beta-1,6-N-acetylglucosaminyl transferase 2, I-branching beta-1,6-N-acetylglucosaminyltransferase, I-branching enzyme, I-branching N-acetylglucosaminyltransferase, IGnT, More, N-acetylglucosaminyltransferase, N-acetyllactosaminide beta-1,6-N-acetylglucosaminyl-transferase, UDP-GlcNAc:Gal-R, beta-D-6-N-acetylglucosaminyltransferase, UDP-N-acetyl-D-glucosamine:beta-D-galactosyl-(1->4)-N-acetyl-D-glucosaminide 6-beta-N-acetyl-D-glucosaminyltransferase, uridine diphosphoacetylglucosamine-acetyllactosaminide beta1-->6-acetylglucosaminyltransferase
ECTree
2.4.1.150 N-acetyllactosaminide beta-1,6-N-acetylglucosaminyltransferaseAdvanced search results
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results (Natural Substrates Products
Natural Substrates Products on EC 2.4.1.150 - N-acetyllactosaminide beta-1,6-N-acetylglucosaminyltransferase
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NATURAL SUBSTRATE 
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
UDP-N-acetyl-D-glucosamine + oligo-N-acetyllactosaminoglycan
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involved in midchain branching of oligo-N-acetyllactosaminoglycans by transferring GlcNAc in beta1,6-linkage to internal galactose residues
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UDP-N-acetyl-D-glucosamine + poly-N-acetyllactosaminoglycan
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might function in biosynthesis of cell surface polylactosaminoglycans on Novikoff cells and blood group I antigenic structures, formation of the GlcNAcbeta(1-3)(GlcNAcbeta(1-6))Gal-R branching points in the branched type of polylactosylaminoglycans
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?
UDP-N-acetyl-D-glucosamine + poly-N-acetyllactosamine
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responsible for the conversion of linear to branched polylactosamines, cIGnT6 actions at central rather than peridistal galactose residues of linear polylactosamines in the biosynthesis of blood group I antigens
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UDP-N-acetyl-D-glucosamine + poly-N-acetyllactosamine
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forms branches in poly-N-acetyllactosamines, which bear the I blood group antigen
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UDP-N-acetyl-D-glucosamine + poly-N-acetyllactosamine
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forms branches in poly-N-acetyllactosamines, which bear the I blood group antigen
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?
UDP-N-acetyl-D-glucosamine + poly-N-acetyllactosamine
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responsible for the formation of the beta1-6-branched poly-N-acetyllactosamine structure, involved in generating branches to central positions of preformed as well as growing polylactosamine chains but not in synthesizing the distal branches to growing chains
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additional information
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initiates formation of side chains, key enzyme in biosynthesis of I antigen of erythrocytes, N-acetyllactosamine is a more physiological acceptor than lactose
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additional information
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expression of I-antigen is entirely dependent on IGnT, expression of IGnT is developmentally regulated
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additional information
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C2GnT forms the core 2 O-glycan branch, which is critical for oligosaccharide-mediated cell-cell interaction, IGnT forms the I antigen, both are members of a beta-1,6-N-acetylglucosaminyltransferase gene family
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additional information
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a major enzyme involved in the branching of poly-N-acetyllactosamine chains in embryoglycan, branching of poly-N-acetyllactosamine chains is performed by beta1,6-N-acetylglucosaminylation of the galactosyl residue
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additional information
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the enzyme should mostly be responsible for making distal I-branch structures on poly-N-acetyllactosamine sequences in small intestine, as well as making mucin core 2 and core 4 structures, it alos has high C2/C4GnT activities
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