2.4.1.150: N-acetyllactosaminide beta-1,6-N-acetylglucosaminyltransferase
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For detailed information about N-acetyllactosaminide beta-1,6-N-acetylglucosaminyltransferase, go to the full flat file.
Word Map on EC 2.4.1.150
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2.4.1.150
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cataract
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poly-n-acetyllactosamine
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cryaa
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n-acetyllactosamine
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polylactosamines
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glycan-binding
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diagnostics
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pharmacology
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medicine
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synthesis
- 2.4.1.150
- cataract
- poly-n-acetyllactosamine
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cryaa
- n-acetyllactosamine
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polylactosamines
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glycan-binding
- diagnostics
- pharmacology
- medicine
- synthesis
Reaction
Synonyms
2beta-1,6-acetylglucosaminyltransferase, acetylglucosaminyltransferase, uridine diphosphoacetylglucosamine-acetyllactosaminide beta1-->6-, beta1-6GnT, C2/4GnT, C24GNT, C2GnT, C2GnT2, C2GNTM, core 2 beta-1,6-N-acetylglucosaminyltransferase, core 2beta-1,6-acetylglucosaminyltransferase, dIHnT, distally acting I-branching beta1,6-N-acetylglucosaminyltransferase, EC 2.4.1.164, Galbeta1-->4GlcNAc-R beta1-->6 N-acetylglucosaminyltransferase, GCNT2, Gcnt2 gene product, gcnt3, glucosaminyl (N-acetyl) transferase 2, GNTM, I beta1,6-N-acetylglucosaminyltransferase, I N-acetylglucosaminyltransferase, I-branching beta-1,6-N-acetylglucosaminyl transferase 2, I-branching beta-1,6-N-acetylglucosaminyltransferase, I-branching enzyme, I-branching N-acetylglucosaminyltransferase, IGnT, More, N-acetylglucosaminyltransferase, N-acetyllactosaminide beta-1,6-N-acetylglucosaminyl-transferase, UDP-GlcNAc:Gal-R, beta-D-6-N-acetylglucosaminyltransferase, UDP-N-acetyl-D-glucosamine:beta-D-galactosyl-(1->4)-N-acetyl-D-glucosaminide 6-beta-N-acetyl-D-glucosaminyltransferase, uridine diphosphoacetylglucosamine-acetyllactosaminide beta1-->6-acetylglucosaminyltransferase
ECTree
2.4.1.150 N-acetyllactosaminide beta-1,6-N-acetylglucosaminyltransferaseAdvanced search results
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results (Source Tissue
Source Tissue on EC 2.4.1.150 - N-acetyllactosaminide beta-1,6-N-acetylglucosaminyltransferase
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SOURCE TISSUE 
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
SOURCE
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IGnT is highly expressed in adult cerebellum and the frontal lobe of adult brain, also expression in fetal brain
GCNT2 is overexpressed in highly metastatic breast cancer cell lines. GCNT2 expression is also significantly correlated to the metastatic phenotype in breast tumor samples
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GCNT3 gene expression is downregulated in colorectal cancer (CRC) samples in comparison to non-pathological colon tissue
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native and knockout mutants, mutant cells exhibited a reduced capability in embryoglycan synthesis and adhere weakly to laminin-coated plates
D-3 embryonic stem cells moderately express IGnT A and B
expression of GCNT2 is significantly higher in tumour tissues than in paratumour tissues, tissue microarray analysis
GCNT3 expression in Epstein-Barr virus (EBV)-associated gastric cancer cells and tissues is lower than in EBV-negative gastric cancer cells (EBVnGC) and tissues, and high expression is significantly associated with advanced tumor-lymph node metastasis. GCNT3 is closely related to the ERK signaling pathway and epithelial mesenchymal transition (EMT), regulating cell proliferation, migration, and invasion
GCNT3 is highly expressed in both NSCLC tissues and cell lines
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EOC, GCNT3 expression is analyzed in a cohort of 56 EOC patients followed by a meta-analysis of more than one thousand patients
P-19 embryonal carcinoma cells moderately express IGnT A and B
additional information
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tetracarcinoma cells, IGnT mainly acts as cIGnT, but can also act as dIGnT with 6-30% of the activity of cIGnT
over 95% of human pancreatic cancers are associated with Kras mutations
additional information
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high expression of C2GnT in granulocyte-monocyte cell lineage
additional information
GCNT3 is highly expressed in both NSCLC tissues and cell lines, and higher expression is significantly associated with advanced tumor lymph node metastasis (TNM) stage, positive lymph node metastasis, and poor overall survival. GCNT3 expression is associated with lymph node metastasis and age. But the expression level of GCNT3 is not correlated with gender, tumor location, differentiation grade, etc. Expression of GCNT3 is lower in EBVaGC cells and tissues than that in EBVnGC cells and tissues
additional information
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integrated transcriptomic and proteomic analyses reveal that GCNT3 is linked to cellular cycle, mitosis and proliferation. The non-invasive HT-29 cell line, that is isolated from a primary tumor, shows GCNT3 expression (mRNA and protein). By contrast, cells belonging to metastatic and invasive SW family, e.g. SW620 and SW5FU, do not exhibit measurable GCNT3 expression
