2.4.1.152: 4-galactosyl-N-acetylglucosaminide 3-alpha-L-fucosyltransferase This is an abbreviated version! For detailed information about 4-galactosyl-N-acetylglucosaminide 3-alpha-L-fucosyltransferase, go to the full flat file .
Reaction
GDP-beta-L-fucose +
beta-D-galactosyl-(1->4)-N-acetyl-D-glucosaminyl-R =
GDP +
beta-D-galactosyl-(1->4)-[alpha-L-fucosyl-(1->3)]-N-acetyl-D-glucosaminyl-R
Synonyms 11639FucT, alpha (1,3) fucosyltransferase, alpha (1,3)-fucosyltransferase, alpha 1,3 fucosyltransferase, alpha 1,3/4 fucosyltransferase Lewis 2, alpha 3-fucosyltransferase IX, alpha(1,3)-fucosyltransferase VII, alpha(1,3)fucosyltransferase IV, alpha(1,3)fucosyltransferase VII, alpha(1-3)fucosyltransferase, alpha-(1,3)-fucosyltransferase, alpha-(1,3)-fucosyltransferase 11, alpha-(1,3)-fucosyltransferase IXa, alpha-(1,3/1,4)-fucosyltransferase, alpha-(1,3/1,4)-FucT, alpha-1,3 FucT-VII, alpha-1,3-fucosyltransferase, alpha-1,3-fucosyltransferase 3, alpha-1,3-fucosyltransferase 9D, alpha-1,3-fucosyltransferase VI, alpha-1,3-FucT3, alpha-13-fucosyltransferase VII, alpha-3-fucosyltransferase, alpha-3-L-fucosyltransferase, alpha1,3 fucosyltransferase, alpha1,3 fucosyltransferase VII, alpha1,3 FucT-VII, alpha1,3-fucosyltransferase, alpha1,3-fucosyltransferase 4, alpha1,3-fucosyltransferase 9, alpha1,3-fucosyltransferase C, alpha1,3-fucosyltransferase IX, alpha1,3-fucosyltransferase V, alpha1,3-fucosyltransferase VI, alpha1,3-fucosyltransferase-F, alpha1,3-FucT, alpha1,3-FucTIX, alpha1,3/4-fucosyltransferase, alpha1,3/4-fucosyltransferase VI, alpha1,3FT, alpha1,3fucosyltransferase-VII, alpha1-3 fucosyltransferase, alpha1-3 fucosyltransferase-VII, alpha1-3 FucT, alpha1->3fucosyltransferase, alpha3-fucosyltransferase, alpha3-fucosyltransferase IX, alpha3-fucosyltransferase VII, alpha3-fucosyltransferase-V, alpha3-fucosyltransferase-VI, alpha3/4FucT, CEFT-3, CEFT-4, FT-IV, FT-VII, Fuc-Tb, Fuc-TV, Fuc-TXI, fucosyltransferase, fucosyltransferase 11, fucosyltransferase 4, fucosyltransferase 7, fucosyltransferase IV, fucosyltransferase IX, fucosyltransferase V, fucosyltransferase VI, fucosyltransferase VII, fucosyltransferase, guanosine diphosphofucose-glucoside alpha1-->3-, fucosyltransferase-7, fucosyltransferase-VII, fucosyltransferaseIX, FucT, FucT 9, FucT IX, FucT V, FucT-IX, FucT-VI, FucT-VII, FucT-XI, FucT7, FucT9, FucTC, FucTD, FucTe, FucTVII, FUT VI, FuT-F, FUT-VI, FUT10, FUT11, FUT3, FUT4, FUT5, FUT6, FUT7, Fut9, FUT9a, FutA, FutB, galactoside 3-fucosyltransferase, galactoside 3-L-fucosyltransferase 11, GDL-L-fucose:N-acetyl-beta-D-glucosaminyl alpha-3-L-fucosyltransferase, GDP-Fuc:Galbeta1-4GlcNAc (Fuc to GlcNAc) alpha1-3 fucosyltransferase, GDP-fucose:beta-D-N-acetylglucosaminide 3-alpha-fucosyltransferase, GDP-fucose:Galbeta(1-4)GlcNAc-R alpha(1-3)fucosyltransferase, GDP-L-fucose:1,4-beta-D-galactosyl-N-acetyl-D-galactosaminyl-R 3-L-fucosyltransferase, guanosine diphosphofucose glucoside alpha1->3fucosyltransferase, HP_0379, HP_0651, Lewis type alpha1,3-FucT, lewis-negative alpha-3-fucosyltransferase, LEwis-type alpha1,3-fucosyltransferase, Lj4g3v0598850, More, plasma alpha-3-fucosyltransferase, PylT, rat fucosyltransferase VII, rFuc-TVII, rFUT7, sFUT9, UA948FucT, WP-000487420, WP-000487428, WP-000487430, XM_016585847, zebrafisha1-3fucosyltrasferase 1, zFT1
ECTree
Source Tissue
Source Tissue on EC 2.4.1.152 - 4-galactosyl-N-acetylglucosaminide 3-alpha-L-fucosyltransferase
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transcript of FUT6 mRNA detected
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from patients suffering from cystic fibrosis
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FucT-VI
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at the segmentation period, at 12, 18 and 48 h after fertilization
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FUT7 mRNA minorly expressed in mouse brain endothelial cell line bEND.3
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the enzyme is expressed in endothelial cells lining the high endothelial venules of perpheral lymph nodes, mesenteric lymph nodes and Pevers patches
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rFuc-TVII mRNA expression strongly detected in rat lymph node
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FUT7 mRNA remarkably highly expressed in mouse lymphoid tumor cell line TIB-63
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FUT7 mRNA significantly expressed in mouse macrophage cell line TIB-69
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CHP 134
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predominantly expressed
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in individuals with plasma fucosyltransferase deficiency from Indonesia, either a missense mutation, G739A, in the catalytic domain, or a nonsense mutation, C945A, truncating the COOH terminus of the enzyme, leads to the total loss of the enzymatic activity of FUT6. 9% of individuals on the island of Java lack the plasma type enzyme. Activity is elevated in patients with a variety of malignant disorders, including liver cancer, elevated in heavy alcohol drinkers. Reduction of enzyme level in patients with schizophrenia
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enzyme activity is significantly higher in patients with chronic liver diseases than in that of normal controls
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the plasma enzyme appears at the last trimester of gestation
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transcript of FUT6 mRNA detected
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FT-IV mRNA is the predominant transcript in eosinophils isolated from human blood, TGF-beta1 upregulates FT-IV mRNA expression
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FT-VII mRNA is weakly expressed in eosinophils isolated from human blood, its expression is up-regulated by TGF-beta1 to some extent
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eosinophilic
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neutrophilic
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predominantly expressed
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FUT4 mRNA is prominently expressed in Jurkat cells, a human T cell line, FUT4 and FUT9 mRNA are distinctly up-regulated in Jurkat cells 3 h and 12 h after granzyme B treatment, respectively, whereas other FUT mRNAs are not affected
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FUT9 mRNA is scarcely expressed in Jurkat cells, a human T cell line, FUT4 and FUT9 mRNA are distinctly up-regulated in Jurkat cells 3h and 12 h after granzyme B treatment, respectively, whereas other FUT mRNAs are not affected
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transcript of FUT6 mRNA detected
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during renal organogenesis the myeloid enzyme is progressively replaced by the plasma enzyme in the proximal tubules and later by the Lewis enzyme in Bellinis ducts and calyce
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FUT7 mRNA expression is highly up-regulated in rat kidney allograft 3 to 5 days after transplantation
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rFuc-TVII mRNA expression undetectable in kidney but it is strongly enhanced during acute inflammatory reaction induced by kidney allograft rejection
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transcript of FUT6 mRNA detected
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NTERA-2/cl.D1 cells are cultured and differentiated into NT2N neurons
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NTERA-2/cl.D1 cells are cultured and differentiated into NT2N neurons
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transcript of FUT6 mRNA detected
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additional information
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developmental expression of CEFT isozymes, overview
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enzyme is produced by infection of Trichoplusia ni cells with recombinant baculovirus
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no activity detected in Daudi, Raji and Reh leukemia cells
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recombinant enzyme expressed in Sf-9 cells via baculovirus infection
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throughout the menstrual cycle, FUT4 protein is localized to glandular and luminal epithelium in the endometrium
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