2.4.1.155: alpha-1,6-mannosyl-glycoprotein 6-beta-N-acetylglucosaminyltransferase

This is an abbreviated version!
For detailed information about alpha-1,6-mannosyl-glycoprotein 6-beta-N-acetylglucosaminyltransferase, go to the full flat file.

Word Map on EC 2.4.1.155

2.4.1.155

n-glycans

metastasis

oligosaccharide

n-linked

glycosyltransferases

n-glycosylation

lectin

udp-glcnac

asparagine-linked

trisaccharide

bisect

medicine

beta1,6-branched

gnt-ivs

complex-type

fucosyltransferase

polylactosamine

o-mannosylated

tetra-antennary

swainsonine

leukoagglutinating

glycomic

glcnac-t

diagnostics

drug development

pharmacology

biotechnology

Reaction

beta-D-GlcNAc-(1->2)-[beta-D-GlcNAc-(1->4)]-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc-N-Asn-[protein]

beta-D-GlcNAc-(1->2)-[beta-D-GlcNAc-(1->4)]-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->2)-[beta-D-GlcNAc-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc-N-Asn-[protein]

Synonyms

acetylglucosaminyltransferase, uridine diphosphoacetylglucosamine-alpha-mannoside beta1-6-UDP-N-acetylglucosamine:alpha-mannoside-beta1,6 N-acetylglucosaminyltransferase, alpha-1,3(6)-mannosylglycoprotein beta-1,6-N-acetylglucosaminyltransferase, alpha-1,6-mannosyl-glycoprotein 6-beta-N-acetylglucosaminyltransferase, alpha-mannoside beta-1,6-N-acetylglucosaminyltransferase, beta N-acetylglucosaminyltransferase V, beta-1,6-N-acetylglucosaminyltransferase V, beta1, 6-N-acetylglucosaminyltransferase V, beta1,6-N-acetylglucosaminyltransferase, beta1,6-N-acetylglucosaminyltransferase V, beta1,6-N-acetylglucosaminyltransferase-V, Glc-NAcT-V, GlcNAcT-V, GlcNAcTase-V, glycosyltransferase, GnT-IV, GnT-IX, GnT-V, GnT-Va, GnT-VB, Golgi beta-1,4-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase V, Golgi UCD-GlcNAc:N-acetylglucosaminyltransferase 5, mannoside acetylglucosaminyltransferase 5, Mgat5, N-acetylglucosaminyltransferase V, N-acetylglucosaminyltransferase Va, N-acetylglucosaminyltransferase-V, N-acetylglucosaminyltransferase-Va, N-acetylglucosaminyltransferase-Vb, N-acetylglucsaminyltransferase V, UDP-N-acetylglucosamine:a-mannoside beta-1,6-N-acetylglucosaminyltransferase

ECTree

2 Transferases

2.4 Glycosyltransferases

2.4.1 Hexosyltransferases

2.4.1.155 alpha-1,6-mannosyl-glycoprotein 6-beta-N-acetylglucosaminyltransferase

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Results	in table
5	Activating Compound
3052	AA Sequence
23	Application
1	CAS Registry Number
18	Cloned(Commentary)
1233	Disease/ Diagnostics
9	Expression
40	General Information
3	General Stability
30	Inhibitors
5	Ki Value [mM]
37	KM Value [mM]
22	Localization
16	Metals/Ions
11	Molecular Weight [Da]
36	Natural Substrates/ Products (Substrates)
75	Organism
3	Pathway
15	PDB ID
11	pH Optimum
2	pH Range
1	pH Stability
4	Posttranslational Modification
16	Protein Variants
11	Purification (Commentary)
2	Reaction
13	Reaction Type
75	Reference
170	Source Tissue
16	Specific Activity [micromol/min/mg]
2	Storage Stability
119	Substrates and Products (Substrate)
2	Subunits
129	Synonyms
1	Systematic Name
17	Temperature Optimum [°C]
1	Temperature Stability [°C]

KM Value

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KM Value on EC 2.4.1.155 - alpha-1,6-mannosyl-glycoprotein 6-beta-N-acetylglucosaminyltransferase

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0.05 - 1.11

Ac-Val-Glu-Pro-(GlcNAcbeta(1-2)Manalpha1-O-)Thr-Ala-Val-NH2

2 entries

1.28 - 2.4

GlcNAc-beta(1-2)Man-alpha(1-3)(GlcNAc-beta(1-2)Man-alpha(1-4))Man-beta(1-4)GlcNAc-2-amino pyridine

2 entries

0.53 - 1.82

GlcNAcbeta(1-2)Manalpha(1-2)Glc-O-octyl

2 entries

0.61 - 0.88

GlcNAcbeta(1-2)Manalpha1-O-benzyl

2 entries

0.133

GlcNAcbeta(1->2)Manalpha(1->3)-[GlcNAcbeta(1->2)Manalpha(1->6)]-Manbeta(1->4)GlcNAcbeta(1->4)GlcNAc-pyridylamine

Homo sapiens

638545

0.25

N-acetyl-D-glucosamine

Mesocricetus auratus

488370

0.074

N-acetyl-D-glucosaminyl-1,2-alpha-4-deoxy-mannosyl-1,6-beta-D-glucosyl-O-(CH2)7-CH3

Mesocricetus auratus

638547

0.13 - 0.23

N-acetyl-D-glucosaminyl-1,2-alpha-D-mannosyl-1,3(6)-(N-acetyl-D-glucosaminyl-1,2-alpha-D-mannosyl-1,6(3))-beta-D-mannosyl-1,4-N-acetyl-D-glucosaminyl-R

4 entries

0.023 - 0.036

N-acetyl-D-glucosaminyl-1,2-alpha-mannosyl-1,6-beta-glucosyl-O-(CH2)7-CH3

2 entries

0.18

N-acetyl-D-glucosaminyl-1,2-alpha-mannosyl-1,6-beta-mannosyl-O-(CH2)-COOCH3

Mesocricetus auratus

488370

0.087

N-acetyl-D-glucosaminyl-1,2-alpha-mannosyl-1,6-beta-mannosyl-O-(CH2)8COOCH3

Rattus norvegicus

638549

2.9

TDP-glucose

Homo sapiens

638558

4.5 - 5.8

UDP-GlcNAc

2 entries

2.9

UDP-glucose

Homo sapiens

638558

0.56 - 1.62

UDP-N-acetyl-D-glucosamine

2 entries

1.1 - 11

UDP-N-acetylglucosamine

9 entries

0.66 - 1.4

UDP-N-acetylgucosamine

2 entries

additional information

Mesocricetus auratus

kinetic study

638547