2.4.1.174: glucuronylgalactosylproteoglycan 4-beta-N-acetylgalactosaminyltransferase
This is an abbreviated version!
For detailed information about glucuronylgalactosylproteoglycan 4-beta-N-acetylgalactosaminyltransferase, go to the full flat file.
Word Map on EC 2.4.1.174
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2.4.1.174
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glycosaminoglycans
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proteoglycans
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aggrecan
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laxity
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perineuronal
- 2.4.1.174
- glycosaminoglycans
- proteoglycans
- aggrecan
- laxity
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perineuronal
Reaction
Synonyms
acetylgalactosaminyltransferase, uridine diphosphoacetylgalactosamine-chondroitin, I, ChGn-1, ChGn-2, chondroitin beta1,4-N-acetylgalactosaminyltransferase-1, chondroitin galactosaminyltransferase, chondroitin N-acetylgalactosaminyltransferase-1, chondroitin N-acetylgalactosaminyltransferase-2, chondroitin sulfate beta-1,4-N-acetylgalactosaminyltransferase-1 ChGn-1, chondroitin sulfate N-acetylgalactosaminyltransferase 1, chondroitin sulfate N-acetylgalactosaminyltransferase 2, chondroitin sulfate N-acetylgalactosaminyltransferase-1, chondroitin sulfate N-acetylgalactosaminyltransferase-2, chondroitin sulfate synthase 1, chondroitin sulfate synthase-1, chondroitin sulphate N-acetylgalactosaminyl-transferase-1, chondroitin sulphate N-acetylgalactosaminyltransferase 1, CHSY1, CS N-acetylgalactosaminyltransferase 1, CS N-acetylgalactosaminyltransferase-1, CSGal-NACT-1, CSGalNAcT-1, CSGalNAcT1, CSGALNACT2, CSS1, GalNAcT-I, GalNAcT-II, glucuronylgalactosylproteoglycan beta-1,4-N-acetylgalactosaminyltransferase, More, N-acetylgalactosamineT-II, N-acetylgalactosaminyltransferase I, uridine diphosphoacetylgalactosamine-chondroitin acetylgalactosaminyltransferase I
ECTree
2.4.1.174 glucuronylgalactosylproteoglycan 4-beta-N-acetylgalactosaminyltransferaseAdvanced search results
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results (Expression
Expression on EC 2.4.1.174 - glucuronylgalactosylproteoglycan 4-beta-N-acetylgalactosaminyltransferase
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EXPRESSION 
ORGANISM
UNIPROT
LITERATURE
cajanine is a stilbenic component isolated from Cajanus cajan, it is identified as a potent hepatitis C virus (HCV) inhibitor by phenotypic screening with EC50 of 0.00317 mM. Cajanine inhibits HCV infection by targeting cellular CSGalNAcT-1 protein destabilizing the protein. Cajanine does not inhibit HCV replication at the replicative steps of HCV life cycle. CSGalNAcT-1 is important to support HCV replication at the early stage. Structure-activity relationships and the mechanism of action, and analysis of cajanine derivatives, overview. Cajanine might inhibit HCV replication at early steps of the viral life cycle via downregulating of cellular CSGalNAcT-1
CSGalNAcT2 gene expression is upregulated during infectious bursal disease virus, IBDV, infection
enzyme expression is induced by Neutropin (NTP). Neurotropin activates the phosphatidylinositol 3-kinase-AKT pathway and AKT stimulation, it stimulate glycosaminoglycan synthesis through upregulation of expression of mRNA for chondroitin sulfate N-acetylgalactosaminyltransferase 1. Gene expression profiling shows over 2fold upregulation of 697 genes in response to Neurotropin treatment. Upregulation of IGF1, ANG1, and CSGALNACT1 expression by NTP. Neurotropin (NTP) is a nonprotein extract from inflamed rabbit skin inoculated with vaccinia virus, it has been widely used in Japan and China as an analgesic drug for treatment of chronic pain, such as LBP, postherpetic neuralgia, neck-shoulder-arm syndrome, hyperesthesia of subacute myelo-optic neuropathy, and fibromyalgia. Addition of NTP to the culture medium of nucleus pulposus cells enhances proteoglycan synthesis to halt progressive intervertebral disc (IVD) degeneration
induction of gene CSGalNAcT-2 by NTP is much lower compared to CSGalNAcT-1
T1 is upregulated in reactive astrocytes after spinal cord injury (SCI)
the enzyme is downregulated in Kashin-Beck disease (KBD), an endemic degenerative osteoarthritis, and in primary osteoarthritis, both associated with extracellular matrix degradation
