2.4.1.175: glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase

This is an abbreviated version!
For detailed information about glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase, go to the full flat file.

Reaction

Synonyms

AcbD, acetylgalactosaminyltransferase, uridine diphosphoacetylgalactosamine-chondroitin, II, ApCS, bifunctional CS synthase, ChGn-1, ChGn-2, chondroitin galactosaminyltransferase, chondroitin N-acetylgalactosaminyltransferase-1, chondroitin N-acetylgalactosaminyltransferase-2, chondroitin polymerase, chondroitin sulfate beta-1,4-N-acetylgalactosaminyltransferase-1, chondroitin sulfate glucuronyltransferase, chondroitin sulfate glycosyltransferase, chondroitin sulfate N-acetylgalactosaminyltransferase-1, chondroitin sulfate N-acetylgalactosaminyltransferase-2, chondroitin sulfate synthase 1, chondroitin sulfate synthase-1, chondroitin sulfate synthase-2, chondroitin sulfate synthase-2/chondroitin polymerizing factor, chondroitin sulfate synthase-3, chondroitin synthase, chondroitin synthase 1, chondroitin synthase-1, chondroitin synthase-2, chondroitin synthase-3, CHPF, ChSy, ChSy-1, ChSy-2, ChSy-3, CHSY1, CpCS, Cpha266_2341, CS glycosyltransferase, CS N-acetylgalactosaminyltransferase-1, CS synthase 1, CS synthase-1, CSGalNAcT-2, CSGlcA-T, CSS1, CSS2, CSS3, GalNAc-T, glucuronyl-N-acetylgalactosaminylproteoglycan beta1,4-N-acetylgalactosaminyltransferase, K4CP, More, N-acetylgalactosaminyltransferase II, UDP-N-acetyl-D-galactosamine:D-glucuronyl-N-acetyl-1,3-beta-D-galactosaminylproteoglycan beta-1,4-N-acetylgalactosaminyltransferase, uridine diphosphoacetylgalactosamine-chondroitin acetylgalactosaminyltransferasec II

ECTree

     2 Transferases

         2.4 Glycosyltransferases

             2.4.1 Hexosyltransferases

                2.4.1.175 glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase

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Results	in table
1	Activating Compound
121	AA Sequence
6	Application
1	CAS Registry Number
27	Cloned(Commentary)
1	Crystallization (Commentary)
30	Disease/ Diagnostics
4	Expression
38	General Information
4	General Stability
7	Inhibitors
1	kcat/KM [mM/s]
8	KM Value [mM]
22	Localization
19	Metals/Ions
4	Molecular Weight [Da]
25	Natural Substrates/ Products (Substrates)
57	Organism
5	Pathway
6	PDB ID
13	pH Optimum
2	Posttranslational Modification
15	Protein Variants
9	Purification (Commentary)
3	Reaction
1	Reaction Type
46	Reference
147	Source Tissue
13	Specific Activity [micromol/min/mg]
1	Storage Stability
148	Substrates and Products (Substrate)
7	Subunits
112	Synonyms
1	Systematic Name
9	Temperature Optimum [°C]
1	Temperature Range [°C]
4	Temperature Stability [°C]
1	Turnover Number [1/s]

Natural Substrates Products

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Natural Substrates Products on EC 2.4.1.175 - glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase

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NATURAL SUBSTRATE

NATURAL PRODUCT

REACTION DIAGRAM

ORGANISM

UNIPROT

COMMENTARY
(Substrate)

LITERATURE
(Substrate)

COMMENTARY
(Product)

LITERATURE
(Product)

REVERSIBILITY
r=reversible
ir=irreversible
?=not specified

UDP-N-acetyl-alpha-D-galactosamine + beta-D-glucuronosyl-(1->3)-N-acetyl-beta-D-galactosaminyl-proteoglycan

UDP + N-acetyl-beta-D-galactosaminyl-(1->4)-beta-D-glucuronosyl-(1->3)-N-acetyl-beta-D-galactosaminyl-proteoglycan

2 entries

UDP-N-acetyl-alpha-D-galactosamine + chondroitin oligosaccharide

UDP + N-acetyl-beta-D-galactosaminyl chondroitin oligosaccharide

5 entries

UDP-N-acetyl-alpha-D-galactosamine + chondroitin sulfate oligosaccharide

UDP + N-acetyl-beta-D-galactosaminyl chondroitin sulfate oligosaccharide

5 entries

UDP-N-acetyl-D-galactosamine + beta-D-glucuronyl-(1->3)-N-acetyl-beta-D-galactosaminyl-proteoglycan

UDP + N-acetyl-D-galactosaminyl-(1->4)-beta-D-glucuronosyl-(1->3)-N-acetyl-beta-D-galactosaminyl-proteoglycan

Mus musculus

-

-

723586

-

-

?

additional information

?

-

7 entries

UDP-N-acetyl-alpha-D-galactosamine + beta-D-glucuronosyl-(1->3)-N-acetyl-beta-D-galactosaminyl-proteoglycan

UDP + N-acetyl-beta-D-galactosaminyl-(1->4)-beta-D-glucuronosyl-(1->3)-N-acetyl-beta-D-galactosaminyl-proteoglycan

Homo sapiens

Q86X52

-

735696, 736226, 736890

-

-

?

UDP-N-acetyl-alpha-D-galactosamine + beta-D-glucuronosyl-(1->3)-N-acetyl-beta-D-galactosaminyl-proteoglycan

UDP + N-acetyl-beta-D-galactosaminyl-(1->4)-beta-D-glucuronosyl-(1->3)-N-acetyl-beta-D-galactosaminyl-proteoglycan

Rattus norvegicus

-

-

735915

-

-

?

UDP-N-acetyl-alpha-D-galactosamine + chondroitin oligosaccharide

UDP + N-acetyl-beta-D-galactosaminyl chondroitin oligosaccharide

Bos taurus

-

involved in chondroitin biosynthesis

638344, 638353, 638356

-

-

?

UDP-N-acetyl-alpha-D-galactosamine + chondroitin oligosaccharide

UDP + N-acetyl-beta-D-galactosaminyl chondroitin oligosaccharide

Escherichia coli

-

biosynthesis of K4 antigen, a capsule polysaccharide consisting of a chondroitin backbone to which beta-fructose is linked at position C-3 of the GlcNAc residue

638357

-

-

?

UDP-N-acetyl-alpha-D-galactosamine + chondroitin oligosaccharide

UDP + N-acetyl-beta-D-galactosaminyl chondroitin oligosaccharide

Escherichia coli

Q8L0V4

biosynthesis of K4 antigen, a capsule polysaccharide consisting of a chondroitin backbone to which beta-fructose is linked at position C-3 of the GlcNAc residue

638352

-

-

?

UDP-N-acetyl-alpha-D-galactosamine + chondroitin oligosaccharide

UDP + N-acetyl-beta-D-galactosaminyl chondroitin oligosaccharide

Homo sapiens

Q8TDX6

involved in chondroitin biosynthesis

638346

-

-

?

UDP-N-acetyl-alpha-D-galactosamine + chondroitin oligosaccharide

UDP + N-acetyl-beta-D-galactosaminyl chondroitin oligosaccharide

Homo sapiens

Q8N6G5, Q8TDX6

involved in chondroitin biosynthesis

638347

-

-

?

UDP-N-acetyl-alpha-D-galactosamine + chondroitin sulfate oligosaccharide

UDP + N-acetyl-beta-D-galactosaminyl chondroitin sulfate oligosaccharide

Bos taurus

-

involved in chondroitin sulfate biosynthesis: elongation of growing chondroitin sulfate chain

638344, 638353, 638356

-

-

?

UDP-N-acetyl-alpha-D-galactosamine + chondroitin sulfate oligosaccharide

UDP + N-acetyl-beta-D-galactosaminyl chondroitin sulfate oligosaccharide

Escherichia coli

Q8L0V4

-

638352, 702023

-

-

?

UDP-N-acetyl-alpha-D-galactosamine + chondroitin sulfate oligosaccharide

UDP + N-acetyl-beta-D-galactosaminyl chondroitin sulfate oligosaccharide

Escherichia coli K4

Q8L0V4

-

702023

-

-

?

UDP-N-acetyl-alpha-D-galactosamine + chondroitin sulfate oligosaccharide

UDP + N-acetyl-beta-D-galactosaminyl chondroitin sulfate oligosaccharide

Homo sapiens

Q8TDX6

involved in chondroitin sulfate biosynthesis: elongation of growing chondroitin sulfate chain

638346

-

-

?

UDP-N-acetyl-alpha-D-galactosamine + chondroitin sulfate oligosaccharide

UDP + N-acetyl-beta-D-galactosaminyl chondroitin sulfate oligosaccharide

Homo sapiens

Q8N6G5, Q8TDX6

involved in chondroitin sulfate biosynthesis: elongation of growing chondroitin sulfate chain

638347

-

-

?

additional information

?

-

Homo sapiens

Q70JA7

CSS3 is a glycosyltransferase having both glucuronyltransferase and N-acetylgalactosaminyltransferase activities. It may make a contribution to CS biosynthesis that differs from that of CSS1

659262

-

-

?

additional information

?

-

Homo sapiens

Q8IZ52

enzyme exhibits the glucuronyltransferase-II (GlcAT-II) and N-acetylgalactosaminyltransferase-II (GalNAcT-II) activities responsible for the biosynthesis of repeating disaccharide units of chondroitin sulfate. Chondroitin polymerizing factor (ChPF) is required for chondroitin polymerizing activity

659218

-

-

?

additional information

?

-

Homo sapiens

A2V663

possess N-acetylgalactosaminyltransferase-II and glucuronyltransferase-II activities responsible for the elongation of chondroitin sulfate chains but cannot polymerize chondroitin chains by themselves

690806

-

-

?

additional information

?

-

Homo sapiens

Q70JA7

experimental data suggest that enzyme acts as a chondroitin polymerase through its interaction with other ChSy family members in the Golgi apparatus

693037

-

-

?

additional information

?

-

Homo sapiens

-

experimental data suggest that enzyme acts as a chondroitin polymerase through its interaction with other ChSy family members in the Golgi apparatus

693037

-

-

?

additional information

?

-

Homo sapiens

Q86X52

chondroitin synthase-1 has two glycosyltransferase activities: it acts as a GlcUA and a GalNAc transferase and is responsible for adding repeated disaccharide units to growing chondroitin sulfate chains

735696

-

-

?

additional information

?

-

Homo sapiens

-

chondroitin synthase-1 has two glycosyltransferase activities: it acts as a GlcUA and a GalNAc transferase and is responsible for adding repeated disaccharide units to growing chondroitin sulfate chains

735696

-

-

?