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2.4.1.175: glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase

This is an abbreviated version!
For detailed information about glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase, go to the full flat file.

Word Map on EC 2.4.1.175

Reaction

UDP-N-acetyl-alpha-D-galactosamine
+
[protein]-3-O-(beta-D-GlcA-(1->3)-beta-D-GalNAc-(1->4)-beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl)-L-serine
=
UDP
 +
[protein]-3-O-(beta-D-GalNAc-(1->4)-beta-D-GlcA-(1->3)-beta-D-GalNAc-(1->4)-beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl)-L-serine

Synonyms

AcbD, acetylgalactosaminyltransferase, uridine diphosphoacetylgalactosamine-chondroitin, II, ApCS, bifunctional CS synthase, ChGn-1, ChGn-2, chondroitin galactosaminyltransferase, chondroitin N-acetylgalactosaminyltransferase-1, chondroitin N-acetylgalactosaminyltransferase-2, chondroitin polymerase, chondroitin sulfate beta-1,4-N-acetylgalactosaminyltransferase-1, chondroitin sulfate glucuronyltransferase, chondroitin sulfate glycosyltransferase, chondroitin sulfate N-acetylgalactosaminyltransferase-1, chondroitin sulfate N-acetylgalactosaminyltransferase-2, chondroitin sulfate synthase 1, chondroitin sulfate synthase-1, chondroitin sulfate synthase-2, chondroitin sulfate synthase-2/chondroitin polymerizing factor, chondroitin sulfate synthase-3, chondroitin synthase, chondroitin synthase 1, chondroitin synthase-1, chondroitin synthase-2, chondroitin synthase-3, CHPF, ChSy, ChSy-1, ChSy-2, ChSy-3, CHSY1, CpCS, Cpha266_2341, CS glycosyltransferase, CS N-acetylgalactosaminyltransferase-1, CS synthase 1, CS synthase-1, CSGalNAcT-2, CSGlcA-T, CSS1, CSS2, CSS3, GalNAc-T, glucuronyl-N-acetylgalactosaminylproteoglycan beta1,4-N-acetylgalactosaminyltransferase, K4CP, More, N-acetylgalactosaminyltransferase II, UDP-N-acetyl-D-galactosamine:D-glucuronyl-N-acetyl-1,3-beta-D-galactosaminylproteoglycan beta-1,4-N-acetylgalactosaminyltransferase, uridine diphosphoacetylgalactosamine-chondroitin acetylgalactosaminyltransferasec II

ECTree

     2 Transferases
         2.4 Glycosyltransferases
             2.4.1 Hexosyltransferases
                2.4.1.175 glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase

Reference

topprint

Reference on EC 2.4.1.175 - glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase

Please use the Reference Search for a specific query.
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REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Rohrmann, K.; Niemann, R.; Buddecke, E.
Two N-acetylgalactosaminyltransferases are involved in the biosynthesis of chondroitin sulfate
Eur. J. Biochem.
148
463-469
1985
Bos taurus
Manually annotated by BRENDA team
Gotoh, M.; Sato, T.; Akashima, T.; Iwasaki, H.; Kameyama, A.; Mochizuki, H.; Yada, T.; Inaba, N.; Zhang, Y.; Kikuchi, N.; Kwon, Y.D.; Togayachi, A.; Kudo, T.; Nishihara, S.; Watanabe, H.; Kimata, K.; Narimatsu, H.
Enzymatic synthesis of chondroitin with a novel chondroitin sulfate N-acetylgalactosaminyltransferase that transfers N-acetylgalactosamine to glucuronic acid in initiation and elongation of chondroitin sulfate synthesis
J. Biol. Chem.
277
38189-38196
2002
Homo sapiens (Q8TDX6)
Manually annotated by BRENDA team
Uyama, T.; Kitagawa, H.; Tamura, J.I.; Sugahara, K.
Molecular cloning and expression of human chondroitin N-acetylgalactosaminyltransferase. The key enzyme for chain initiation and elongation of chondroitin/dermatan sulfate on the protein linkage region tetrasaccharide shared by heparin/heparan sulfate
J. Biol. Chem.
277
8841-8846
2002
Homo sapiens (Q8TDX6)
Manually annotated by BRENDA team
Uyama, T.; Kitagawa, H.; Tanaka, J.; Tamura, J.i.; Ogawa, T.; Sugahara, K.
Molecular cloning and expression of a second chondroitin N-acetylgalactosaminyltransferase involved in the initiation and elongation of chondroitin/dermatan sulfate
J. Biol. Chem.
278
3072-3078
2003
Homo sapiens (Q8N6G5), Homo sapiens (Q8TDX6)
Manually annotated by BRENDA team
Kitagawa, H.; Uyama, T.; Sugahara, K.
Molecular cloning and expression of a human chondroitin synthase
J. Biol. Chem.
276
38721-38726
2001
Homo sapiens (Q86X52)
Manually annotated by BRENDA team
Ninomiya, T.; Sugiura, N.; Tawada, A.; Sugimoto, K.; Watanabe, H.; Kimata, K.
Molecular cloning and characterization of chondroitin polymerase from Escherichia coli strain K4
J. Biol. Chem.
277
21567-21575
2002
Escherichia coli (Q8L0V4), Escherichia coli, Escherichia coli K4 (Q8L0V4)
Manually annotated by BRENDA team
Kitagawa, H.; Tsuchida, K.; Ujikawa, M.; Sugahara, K.
Detection and characterization of UDP-GalNAc: chondroitin N-acetylgalactosaminyltransferase in bovine serum using a simple assay method
J. Biochem.
117
1083-1087
1995
Bos taurus, Rattus norvegicus
Manually annotated by BRENDA team
DeAngelis, P.L.; Padgett-McCue, A.J.
Identification and molecular cloning of a chondroitin synthase from Pasteurella multocida type F
J. Biol. Chem.
275
24124-24129
2000
Pasteurella multocida (Q9CMP0)
Manually annotated by BRENDA team
Tsuchida, K.; Lind, T.; Kitagawa, H.; Lindahl, U.; Sugahara, K.; Lidholt, K.
Purification and characterization of fetal bovine serum beta-N-acetyl-D-galactosaminyltransferase and beta-D-glucuronyltransferase involved in chondroitin sulfate biosynthesis
Eur. J. Biochem.
264
461-467
1999
Bos taurus
Manually annotated by BRENDA team
DeAngelis, P.L.
Microbial glycosaminoglycan glycosyltransferases
Glycobiology
12
9R-16R
2002
Escherichia coli, Pasteurella multocida (Q9CMP0), Escherichia coli K4
Manually annotated by BRENDA team
Kitagawa, H.; Izumikawa, T.; Uyama, T.; Sugahara, K.
Molecular cloning of a chondroitin polymerizing factor that cooperates with chondroitin synthase for chondroitin polymerization
J. Biol. Chem.
278
23666-23671
2003
Homo sapiens (Q8IZ52)
Manually annotated by BRENDA team
Yada, T.; Sato, T.; Kaseyama, H.; Gotoh, M.; Iwasaki, H.; Kikuchi, N.; Kwon, Y.D.; Togayachi, A.; Kudo, T.; Watanabe, H.; Narimatsu, H.; Kimata, K.
Chondroitin sulfate synthase-3. Molecular cloning and characterization
J. Biol. Chem.
278
39711-39725
2003
Homo sapiens (Q70JA7)
Manually annotated by BRENDA team
Sakai, K.; Kimata, K.; Sato, T.; Gotoh, M.; Narimatsu, H.; Shinomiya, K.; Watanabe, H.
Chondroitin sulfate N-acetylgalactosaminyltransferase-1 plays a critical role in chondroitin sulfate synthesis in cartilage
J. Biol. Chem.
282
4152-4161
2007
Mus musculus
Manually annotated by BRENDA team
Izumikawa, T.; Uyama, T.; Okuura, Y.; Sugahara, K.; Kitagawa, H.
Involvement of chondroitin sulfate synthase-3 (chondroitin synthase-2) in chondroitin polymerization through its interaction with chondroitin synthase-1 or chondroitin-polymerizing factor
Biochem. J.
403
545-552
2007
Homo sapiens (A2V663)
Manually annotated by BRENDA team
Izumikawa, T.; Koike, T.; Shiozawa, S.; Sugahara, K.; Tamura, J.; Kitagawa, H.
Identification of chondroitin sulfate glucuronyltransferase as chondroitin synthase-3 involved in chondroitin polymerization: chondroitin polymerization is achieved by multiple enzyme complexes consisting of chondroitin synthase family members
J. Biol. Chem.
283
11396-11406
2008
Homo sapiens (Q70JA7), Homo sapiens
Manually annotated by BRENDA team
Zou, X.H.; Jiang, Y.Z.; Zhang, G.R.; Jin, H.M.; Nguyen, T.M.; Ouyang, H.W.
Specific interactions between human fibroblasts and particular chondroitin sulfate molecules for wound healing
Acta Biomater.
5
1588-1595
2009
Homo sapiens
Manually annotated by BRENDA team
Osawa, T.; Sugiura, N.; Shimada, H.; Hirooka, R.; Tsuji, A.; Shirakawa, T.; Fukuyama, K.; Kimura, M.; Kimata, K.; Kakuta, Y.
Crystal structure of chondroitin polymerase from Escherichia coli K4
Biochem. Biophys. Res. Commun.
378
10-14
2009
Escherichia coli (Q8L0V4), Escherichia coli K4 (Q8L0V4), Escherichia coli K4
Manually annotated by BRENDA team
Tew, S.R.; Pothacharoen, P.; Katopodi, T.; Hardingham, T.E.
SOX9 transduction increases chondroitin sulfate synthesis in cultured human articular chondrocytes without altering glycosyltransferase and sulfotransferase transcription
Biochem. J.
414
231-236
2008
Homo sapiens
Manually annotated by BRENDA team
Yin, J.; Sakamoto, K.; Zhang, H.; Ito, Z.; Imagama, S.; Kishida, S.; Natori, T.; Sawada, M.; Matsuyama, Y.; Kadomatsu, K.
Transforming growth factor-beta1 upregulates keratan sulfate and chondroitin sulfate biosynthesis in microglias after brain injury
Brain Res.
1263
10-22
2009
Mus musculus
Manually annotated by BRENDA team
Sugiura, N.; Shimokata, S.; Minamisawa, T.; Hirabayashi, J.; Kimata, K.; Watanabe, H.
Sequential synthesis of chondroitin oligosaccharides by immobilized chondroitin polymerase mutants
Glycoconj. J.
25
521-530
2008
Escherichia coli, Escherichia coli K4
Manually annotated by BRENDA team
Sobhany, M.; Kakuta, Y.; Sugiura, N.; Kimata, K.; Negishi, M.
The chondroitin polymerase K4CP and the molecular mechanism of selective bindings of donor substrates to two active sites
J. Biol. Chem.
283
32328-32333
2008
Escherichia coli, Escherichia coli K4
Manually annotated by BRENDA team
Izumikawa, T.; Okuura, Y.; Koike, T.; Sakoda, N.; Kitagawa, H.
Chondroitin 4-O-sulfotransferase-1 regulates the chain length of chondroitin sulfate in co-operation with chondroitin N-acetylgalactosaminyltransferase-2
Biochem. J.
434
321-331
2011
Mus musculus
Manually annotated by BRENDA team
Ogawa, H.; Shionyu, M.; Sugiura, N.; Hatano, S.; Nagai, N.; Kubota, Y.; Nishiwaki, K.; Sato, T.; Gotoh, M.; Narimatsu, H.; Shimizu, K.; Kimata, K.; Watanabe, H.
Chondroitin sulfate synthase-2/chondroitin polymerizing factor has two variants with distinct function
J. Biol. Chem.
285
34155-34167
2010
Mus musculus
Manually annotated by BRENDA team
Ogawa, H.; Hatano, S.; Sugiura, N.; Nagai, N.; Sato, T.; Shimizu, K.; Kimata, K.; Narimatsu, H.; Watanabe, H.
Chondroitin sulfate synthase-2 is necessary for chain extension of chondroitin sulfate but not critical for skeletal development
PLoS ONE
7
e43806
2012
Mus musculus
Manually annotated by BRENDA team
Izumikawa, T.; Saigoh, K.; Shimizu, J.; Tsuji, S.; Kusunoki, S.; Kitagawa, H.
A chondroitin synthase-1 (ChSy-1) missense mutation in a patient with neuropathy impairs the elongation of chondroitin sulfate chains initiated by chondroitin N-acetylgalactosaminyltransferase-1
Biochim. Biophys. Acta
1830
4806-4812
2013
Homo sapiens (Q86X52), Homo sapiens
Manually annotated by BRENDA team
Hu, B.; Shi, C.; Tian, Y.; Zhang, Y.; Xu, C.; Chen, H.; Cao, P.; Yuan, W.
TGF-beta induces up-regulation of chondroitin sulfate synthase 1 (CHSY1) in nucleus pulposus cells through MAPK signaling
Cell. Physiol. Biochem.
37
793-804
2015
Rattus norvegicus
Manually annotated by BRENDA team
Momose, T.; Yoshimura, Y.; Harumiya, S.; Isobe, K.; Kito, M.; Fukushima, M.; Kato, H.; Nakayama, J.
Chondroitin sulfate synthase 1 expression is associated with malignant potential of soft tissue sarcomas with myxoid substance
Hum. Pathol.
50
15-23
2016
Homo sapiens (Q86X52)
Manually annotated by BRENDA team
Saigoh, K.; Yoshimura, S.; Izumikawa, T.; Miyata, S.; Tabara, Y.; Matsushita, T.; Miki, T.; Miyamoto, K.; Hirano, M.; Kitagawa, H.; Kira, J.I.; Kusunoki, S.
Chondroitin sulfate beta-1,4-N-acetylgalactosaminyltransferase-1 (ChGn-1) polymorphism: association with progression of multiple sclerosis
Neurosci. Res.
108
55-59
2016
Homo sapiens (Q86X52)
Manually annotated by BRENDA team
Wang, T.T.; Zhu, C.Y.; Zheng, S.; Meng, C.C.; Wang, T.T.; Meng, D.H.; Li, Y.J.; Zhu, H.M.; Wang, F.S.; Sheng, J.Z.
Identification and characterization of a chondroitin synthase from Avibacterium paragallinarum
Appl. Microbiol. Biotechnol.
102
4785-4797
2018
Avibacterium paragallinarum (D0QYM5), Avibacterium paragallinarum ATCC 29545 (D0QYM5), Avibacterium paragallinarum NCTC 11296 (D0QYM5)
Manually annotated by BRENDA team
Adhikara, I.M.; Yagi, K.; Mayasari, D.S.; Ikeda, K.; Kitagawa, H.; Miyata, O.; Igarashi, M.; Hatakeyama, K.; Asada, Y.; Hirata, K.I.; Emoto, N.
Chondroitin sulfate N-acetylgalactosaminyltransferase-2 deletion alleviates lipoprotein retention in early atherosclerosis and attenuates aortic smooth muscle cell migration
Biochem. Biophys. Res. Commun.
509
89-95
2019
Mus musculus (Q6IQX7), Homo sapiens (Q8IZ52), Mus musculus C57BL/6J (Q6IQX7)
Manually annotated by BRENDA team
Momose, T.; Yoshimura, Y.; Harumiya, S.; Isobe, K.; Kito, M.; Fukushima, M.; Kato, H.; Nakayama, J.
Chondroitin sulfate synthase 1 expression is associated with malignant potential of soft tissue sarcomas with myxoid substance
Hum. Pathol.
50
15-23
2016
Homo sapiens (Q86X52)
Manually annotated by BRENDA team
Liao, W.C.; Liao, C.K.; Tseng, T.J.; Ho, Y.J.; Chen, Y.R.; Lin, K.H.; Lai, T.J.; Lan, C.T.; Wei, K.C.; Liu, C.H.
Chondroitin sulfate synthase 1 enhances proliferation of glioblastoma by modulating PDGFRA stability
Oncogenesis
9
9
2020
Homo sapiens (Q86X52)
Manually annotated by BRENDA team
Shimbo, M.; Suzuki, R.; Fuseya, S.; Sato, T.; Kiyohara, K.; Hagiwara, K.; Okada, R.; Wakui, H.; Tsunakawa, Y.; Watanabe, H.; Kimata, K.; Narimatsu, H.; Kudo, T.; Takahashi, S.
Postnatal lethality and chondrodysplasia in mice lacking both chondroitin sulfate N-acetylgalactosaminyltransferase-1 and -2
PLoS ONE
12
e0190333
2017
Chlorobium phaeobacteroides (A1BIV2), Chlorobium phaeobacteroides DSM 266 (A1BIV2)
Manually annotated by BRENDA team
Ida-Yonemochi, H.; Morita, W.; Sugiura, N.; Kawakami, R.; Morioka, Y.; Takeuchi, Y.; Sato, T.; Shibata, S.; Watanabe, H.; Imamura, T.; Igarashi, M.; Ohshima, H.; Takeuchi, K.
Craniofacial abnormality with skeletal dysplasia in mice lacking chondroitin sulfate N-acetylgalactosaminyltransferase-1
Sci. Rep.
8
17134
2018
Mus musculus (Q6ZQ11)
Manually annotated by BRENDA team