2.4.1.185: flavanone 7-O-beta-glucosyltransferase
This is an abbreviated version!
For detailed information about flavanone 7-O-beta-glucosyltransferase, go to the full flat file.
Word Map on EC 2.4.1.185
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2.4.1.185
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flavonols
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aglycone
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flavone
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kaempferol
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withania
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trans-glycosylation
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myricetin
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7-o-glucoside
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o-glycosyltransferases
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udp-dependent
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barbata
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delphinidin
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grapefruit
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somnifera
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3-hydroxy
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scutellaria
- 2.4.1.185
- flavonols
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aglycone
- flavone
- kaempferol
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withania
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trans-glycosylation
- myricetin
- 7-o-glucoside
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o-glycosyltransferases
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udp-dependent
- barbata
- delphinidin
- grapefruit
- somnifera
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3-hydroxy
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scutellaria
Reaction
Synonyms
CsUGT76F1, flavonoid glycosyltransferase, glucosyltransferase, uridine diphosphoglucose-flavanone 7-O-, hesperetin 7-O-glucosyl-transferase, naringenin 7-O-glucosyltransferase, UDPglucose:flavanone 7-O-beta-D-glucosyltransferase, UGT73A10
ECTree
2.4.1.185 flavanone 7-O-beta-glucosyltransferaseAdvanced search results
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results (Substrates Products
Substrates Products on EC 2.4.1.185 - flavanone 7-O-beta-glucosyltransferase
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SUBSTRATE 
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
UDP-alpha-D-glucose + 4',5',7-trihydroxyflavanone
UDP + 4',5',7-trihydroxyflavanone 7-O-beta-D-glucoside
UDP-alpha-D-glucose + apigenin
UDP + apigenin 7-O-beta-D-glucoside
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peak I-III, 49%, 45% and 95% of activity with naringenin respectively
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?
UDP-alpha-D-glucose + luteolin
UDP + luteolin 7-O-beta-D-glucoside
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peak I, 52% of activity with naringenin
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?
UDP-glucose + isosakuranetin
UDP + isosakuranetin 7-O-beta-D-glucoside
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-
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?
UDP-glucose + kaempferol
UDP + kaempferol 3-O-beta-D-glucoside
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the enzyme can form kaempferol 3,7-O-diglucoside, reaction of EC 2.4.1.91
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-
?
UDP-glucose + kaempferol
UDP + kaempferol 7-O-beta-D-glucoside
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the enzyme can form kaempferol 3,7-O-diglucoside
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-
?
UDP-glucose + quercetin
UDP + quercetin 3-O-beta-D-glucoside
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reaction of EC 2.4.1.91
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-
?
UDPglucose + 2',4',6',4-tetrahydroxychalcone
UDP + 2',4',6',4-tetrahydroxychalcone 4'-O-glucoside
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64% of activity with naringenin
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?
UDP-alpha-D-glucose + 4',5',7-trihydroxyflavanone
UDP + 4',5',7-trihydroxyflavanone 7-O-beta-D-glucoside
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-
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?
UDP-alpha-D-glucose + 4',5',7-trihydroxyflavanone
UDP + 4',5',7-trihydroxyflavanone 7-O-beta-D-glucoside
Citrus mitis
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?
UDP-alpha-D-glucose + 4',5',7-trihydroxyflavanone
UDP + 4',5',7-trihydroxyflavanone 7-O-beta-D-glucoside
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enzyme does not accept other flavanone or flavonol aglycones
trivial name prunin
?
UDP-alpha-D-glucose + 4',5',7-trihydroxyflavanone
UDP + 4',5',7-trihydroxyflavanone 7-O-beta-D-glucoside
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trivial name naringenin
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?
UDP-alpha-D-glucose + 4',5',7-trihydroxyflavanone
UDP + 4',5',7-trihydroxyflavanone 7-O-beta-D-glucoside
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trivial name naringenin
trivial name prunin
?
UDP-alpha-D-glucose + 4',5',7-trihydroxyflavanone
UDP + 4',5',7-trihydroxyflavanone 7-O-beta-D-glucoside
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peak I-III
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?
UDP-alpha-D-glucose + kaempferol
UDP + kaempferol 7-O-beta-D-glucoside
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90% of activity with naringenin
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?
UDP-alpha-D-glucose + kaempferol
UDP + kaempferol 7-O-beta-D-glucoside
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peak I-III, 50%, 46% and 70% of activity with naringenin respectively
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?
UDP-alpha-D-glucose + quercetin
UDP + quercetin 7-O-beta-D-glucoside
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164% of activity with naringenin
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?
UDP-alpha-D-glucose + quercetin
UDP + quercetin 7-O-beta-D-glucoside
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peak I, 42% of activity with naringenin
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?
UDP-glucose + hesperetin
UDP + hesperetin 7-O-glucoside
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trivial name hesperetin, 83% of activity with naringenin
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?
UDP-glucose + hesperetin
UDP + hesperetin 7-O-glucoside
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peak I, 70% of activity with naringenin
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?
UDP-glucose + naringenin
UDP + naringenin 7-O-glucoside
enzyme specificity for UDP-glucose
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?
additional information
?
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the enzyme has flavonoid 7-O-glucosyltransferase and 7-O-rhamnosyltransferase activities in vivo
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additional information
?
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in vitro, enzyme CsUGT76F1 can function as flavonoid 3-O-, 7-O-, and 3,7-O-glucosyltransferase, and as 7-O-rhamnosyltransferase with a broad range of flavonoid substrates that can be glucosylated at their 3- and/or 7-hydrogen sites by the recombinant enzyme, including flavanones, flavonols, and flavons, e.g. hesperetin, naringenin, diosmetin, quercetin, and kaempferol as acceptor substrates, and UDP-glucose and UDP-rhamnose as the sugar donors. Mass spectrometric product analysis (UPLC-Q-TOF-MS). The recombinant UGT can only accept UDP-rhamnose to rhamnosylate the 7-hydrogen position of quercetin and kaempferol, but not to catalyze the rhamnosylation of hesperetin, naringenin, and diosmetin. No flavonoid O-rutinoside (rhamnosyl-alpha-1,6-glucose) or O-neohesperidose (rhamnosyl-alpha-1,2-glucose) products are detected
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additional information
?
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does not use UDP-glucuronic acid, UDP-galactose, ADP-glucose, GDP-glucose, and TDP-glucose with esculetin as the glycosyl acceptor
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?
