2.4.1.186: glycogenin glucosyltransferase This is an abbreviated version! For detailed information about glycogenin glucosyltransferase, go to the full flat file .
Word Map on EC 2.4.1.186
Reaction
UDP-alpha-D-glucose +
glycogenin =
UDP +
alpha-D-glucosylglycogenin
Synonyms CeGN, CgGN, CgGN-alpha, CgGN-beta, CgGN-gamma, EC 2.4.1.112, glucosyltransferase, uridine diphosphoglucose-protein, glucosyltransferase, uridine diphosphoglucose-protein 4-alpha-, glycogen initiator synthase, glycogenin, glycogenin 1, glycogenin 2, glycogenin glycosyltransferase, glycogenin-1, glycogenin-2, glyogenin, GN-1, GN1, GN2, GNN, GYG, GYG1, GYG2, hGYG1, M-glycogenin, priming glucosyltransferase, proglycogen synthase, UDP-glucose protein transglucosylase, UDP-glucose-protein glucosyltransferase, UDP-glucose:protein glucosyltransferase, UDPGlc:protein transglucosylase, UPTG, uridine diphosphate glucose-protein transglucosylase I, uridine diphosphoglucose protein transglucosylase I, uridine diphosphoglucose-protein 4-alpha-glucosyltransferase, uridine diphosphoglucose-protein glucosyltransferase
ECTree
Reaction
Reaction on EC 2.4.1.186 - glycogenin glucosyltransferase
Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
UDP-alpha-D-glucose + glycogenin = UDP + alpha-D-glucosylglycogenin
UDP-alpha-D-glucose + glycogenin = UDP + alpha-D-glucosylglycogenin
The glycogenin subunit of glycogen synthase (EC 2.4.1.11, glycogen(starch) synthase) catalyses this reaction, i.e. the enzyme catalyses its own autoglycosylation. Five molecules of glucose can be transferred to one molecule of glycogenin. The product acts as a primer for the reaction catalysed by glycogen synthase.
-
-
-
UDP-alpha-D-glucose + glycogenin = UDP + alpha-D-glucosylglycogenin
independent active sites for glucosylation of exogenous and self-acceptors
-
UDP-alpha-D-glucose + glycogenin = UDP + alpha-D-glucosylglycogenin
initiation of glycogen biosynthesis is a 2-step mechanism, requiring first the covalent attachment of a glucose residue to Tyr-194 of glycogenin and then elongation to form an oligosaccharide chain
-
UDP-alpha-D-glucose + glycogenin = UDP + alpha-D-glucosylglycogenin
highly conserved protein
-
UDP-alpha-D-glucose + glycogenin = UDP + alpha-D-glucosylglycogenin
highly conserved protein
-
UDP-alpha-D-glucose + glycogenin = UDP + alpha-D-glucosylglycogenin
highly conserved protein
-
UDP-alpha-D-glucose + glycogenin = UDP + alpha-D-glucosylglycogenin
highly conserved protein
-
UDP-alpha-D-glucose + glycogenin = UDP + alpha-D-glucosylglycogenin
highly conserved protein
-
UDP-alpha-D-glucose + glycogenin = UDP + alpha-D-glucosylglycogenin
stereochemistry and mechanism
-
UDP-alpha-D-glucose + glycogenin = UDP + alpha-D-glucosylglycogenin
stereochemistry and mechanism
-
UDP-alpha-D-glucose + glycogenin = UDP + alpha-D-glucosylglycogenin
stereochemistry and mechanism
-
UDP-alpha-D-glucose + glycogenin = UDP + alpha-D-glucosylglycogenin
conformational plasticity of glycogenin and coexistence of two modes of glucosylation as integral to its catalytic mechanism, possible SNi-like mechanism for glucosyl-transfer, overview