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2.4.1.212: hyaluronan synthase

This is an abbreviated version!
For detailed information about hyaluronan synthase, go to the full flat file.

Word Map on EC 2.4.1.212

Reaction

UDP-alpha-D-glucuronate
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N-acetyl-beta-D-glucosaminyl-(1->4)-beta-D-glucuronosyl-(1->3)-[nascent hyaluronan]
=
UDP
+
beta-D-glucuronosyl-(1->3)-N-acetyl-beta-D-glucosaminyl-(1->4)-beta-D-glucuronosyl-(1->3)-[nascent hyaluronan]

Synonyms

CHAS2, CHAS3, class I hyaluronan synthase, CPS1, DG42 protein, HA synthase, HA synthase 3, HA1, HA2, HA3, HAS, HAS-1, HAS-2, HAS-3, HAS1, Has2, Has3, hasA, HASs, HsHAS1, HuHAS1, HyaD, hyaluronan synthase, hyaluronan synthase 1, hyaluronan synthase 2, hyaluronan synthase 3, hyaluronan synthase-1, hyaluronan synthase-2, hyaluronan synthases 2, hyaluronan synthethase, hyaluronate synthase, hyaluronate synthetase, hyaluronic acid synthase, hyaluronic acid synthetase, More, PmHAS, seHAS, XHAS1, XHAS2, XHAS3

ECTree

     2 Transferases
         2.4 Glycosyltransferases
             2.4.1 Hexosyltransferases
                2.4.1.212 hyaluronan synthase

Source Tissue

Source Tissue on EC 2.4.1.212 - hyaluronan synthase

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SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
SOURCE
expression of HAS1 splice variants is absent from B cells of healthy donors and in multiple myeloma and monoclonal gammopathy of undetermined significance (MGUS) is restricted to the B-cell compartment
Manually annotated by BRENDA team
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vitreous body
Manually annotated by BRENDA team
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cell line
Manually annotated by BRENDA team
high isozyme content
Manually annotated by BRENDA team
tumorigenic cell line, 3-5fold higher hyaluronan accumulation than in the parental cell line 3Y1
Manually annotated by BRENDA team
MDA-MB-231 and Hs-578T breast cancer cell line express higher levels of HAS2 mRNA and synthesize higher amounts of HA than breast cancer cell lines with a less aggressive phenotype, like MCF-7
Manually annotated by BRENDA team
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HAS1 expression is shown in 55.7% of SIRPA-positive macrophages in stage III follicles
Manually annotated by BRENDA team
MDA-MB-231 and Hs-578T breast cancer cell line express higher levels of HAS2 mRNA and synthesize higher amounts of HA than breast cancer cell lines with a less aggressive phenotype, like MCF-7. HAS2 is dramatically increased in bone metastases compared to the parental MDA-MB-231 cells
Manually annotated by BRENDA team
embryonic mouse molar. Difference in the distribution and expression of the three hyaluronan synthases at different developmental stages. Hyaluronan synthase 1 and hyaluronan synthase 2, but not hyaluronan synthase 3, are highly expressed in the bud stage
Manually annotated by BRENDA team
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mouse epithelial cell line
Manually annotated by BRENDA team
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Manually annotated by BRENDA team
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expression of isoform HAS1 in theca cells of healthy and early atretic follicles of stage I and stage II and in progressing atretic stage III follicles
Manually annotated by BRENDA team
serous epithelial ovarian tumor
Manually annotated by BRENDA team
serous epithelial ovarian tumor
Manually annotated by BRENDA team
platelet-derived growth factor BB exerts dominant influence on HAS2 isoform expression by osteoblasts
Manually annotated by BRENDA team
metastatic cell line, 3-5fold higher hyaluronan accumulation than in the parental cell line 3Y1
Manually annotated by BRENDA team
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35 endometrial tissue biopsies from 35 patients, including proliferative and secretory endometrium, post-menopausal proliferative endometrium, complex atypical hyperplasia, grade 1 and grade 2 + 3 endometrioid adenocarcinomas. Immunoreactivity of all HAS proteins is increased in the cancer epithelium
Manually annotated by BRENDA team
additional information