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2.4.1.212: hyaluronan synthase

This is an abbreviated version!
For detailed information about hyaluronan synthase, go to the full flat file.

Word Map on EC 2.4.1.212

Reaction

UDP-alpha-D-glucuronate
+
N-acetyl-beta-D-glucosaminyl-(1->4)-beta-D-glucuronosyl-(1->3)-[nascent hyaluronan]
=
UDP
 +
beta-D-glucuronosyl-(1->3)-N-acetyl-beta-D-glucosaminyl-(1->4)-beta-D-glucuronosyl-(1->3)-[nascent hyaluronan]

Synonyms

CHAS2, CHAS3, class I hyaluronan synthase, CPS1, DG42 protein, HA synthase, HA synthase 3, HA1, HA2, HA3, HAS, HAS-1, HAS-2, HAS-3, HAS1, Has2, Has3, hasA, HASs, HsHAS1, HuHAS1, HyaD, hyaluronan synthase, hyaluronan synthase 1, hyaluronan synthase 2, hyaluronan synthase 3, hyaluronan synthase-1, hyaluronan synthase-2, hyaluronan synthases 2, hyaluronan synthethase, hyaluronate synthase, hyaluronate synthetase, hyaluronic acid synthase, hyaluronic acid synthetase, More, PmHAS, seHAS, XHAS1, XHAS2, XHAS3

ECTree

     2 Transferases
         2.4 Glycosyltransferases
             2.4.1 Hexosyltransferases
                2.4.1.212 hyaluronan synthase

Specific Activity

Specific Activity on EC 2.4.1.212 - hyaluronan synthase

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SPECIFIC ACTIVITY [µmol/min/mg]
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
0.0000000062
HAS activity, HAS1siRNA + HAS2siRNA + HAS3siRNA treatment, plus heregulin
0.0000000092
HAS activity, HAS1siRNA + HAS2siRNA + HAS3siRNA treatment
0.000000017
HAS activity, HAS2siRNA treatment
0.0000000175
HAS activity, HAS1siRNA treatment
0.0000000188
HAS activity, HAS3siRNA treatment
0.0000000222
HAS activity, AG825 treatment
0.0000000227
HAS activity, HAS2siRNA treatment, plus heregulin
0.000000023
HAS activity, thiazolidinedione treatment
0.0000000233
HAS activity, no treatment, control
0.0000000237
HAS activity, scrambled sequence treatment, control
0.0000000248
HAS activity, HAS1siRNA treatment, plus heregulin
0.000000025
HAS activity, HAS3siRNA treatment, plus heregulin
0.0000000257
HAS activity, AG825 treatment, plus heregulin
0.0000000263
HAS activity, thiazolidinedione treatment, plus heregulin
0.0000000583
HAS activity, scrambled sequence treatment, control, plus heregulin
0.0000000627
HAS activity, no treatment, control, plus heregulin
0.05
presence of 10 mM Mn2+, pH 7.0, 25°C
13.4
-
mutant C226A/C262A, pH 7.0, 30°C
14
-
deletion mutant DELTA3-C281, pH 7.0, 30°C
16.4
-
mutant C226A, pH 7.0, 30°C
16.5
-
mutant C226S, pH 7.0, 30°C
21.2
-
mutant C281S, pH 7.0, 30°C
22.9
-
deletion mutant C-Null, pH 7.0, 30°C
25.3
-
mutant C226A/C281A, pH 7.0, 30°C
27
-
deletion mutant DELTA3-C367, pH 7.0, 30°C
29.1
-
mutant C262A, pH 7.0, 30°C
29.5
-
mutant C367S, pH 7.0, 30°C
30.2
-
mutant C262A/C281A, pH 7.0, 30°C
31.4
-
mutant C262S, pH 7.0, 30°C
31.6
-
deletion mutant DELTA3-C262, pH 7.0, 30°C
33.7
-
mutant C281A, pH 7.0, 30°C
37
-
wild-type enzyme, pH 7.0, 30°C
37.8
-
mutant C226A/C367A, pH 7.0, 30°C
38.6
-
deletion mutant DELTA3-C226, pH 7.0, 30°C
39.5
-
mutant C281A/C367A, pH 7.0, 30°C
46.7
-
mutant C367A, pH 7.0, 30°C
additional information