2.4.1.214: glycoprotein 3-alpha-L-fucosyltransferase

This is an abbreviated version!
For detailed information about glycoprotein 3-alpha-L-fucosyltransferase, go to the full flat file.

Reaction

Synonyms

alpha 1,3-fucosyltransferase VI, alpha(1,3)-fucosyltransferase VII, alpha(1,3)-fucosyltransferase-IV, alpha(1,3)-fucosyltransferase-VII, alpha(1,3)fucosyltransferase, alpha-1,3-fucosyltransferase-VII, alpha1,3-fucosyltransferase, alpha1,3-fucosyltransferase 10, alpha1,3-fucosyltransferase 7, alpha1,3-fucosyltransferase 9, alpha1,3-fucosyltransferase IX, alpha1,3FTs, alpha1-3 fucosyltransferase-VII, alpha3-fucosyltransferase, alpha3-FucT VII, AtFUT11, CEFT-1, CEFT-2, CEFT-3, CEFT-4, CEFT-5, CEFT3, core alpha-(1,3)-fucosyltransferase, core alpha1,3-fucosyltransferase, Fuc-T C3, Fuc-TVII, fucosyltransferase A, fucosyltransferase VII, FucT, FucT 115, FucT 45, FucT VI, FucT VII, FucT-IV, FucT-VII, FucT1, FucTA, FucTB, FucTC, FUT-1, FUT-6, FUT10, FUT11, FUT7, Fut9, GDP-fucose:beta-N-acetylglucosamine (Fuc to (Fuca1-6GlcNAc)-Asn-peptide) alpha1-3-fucosyltransferase, GDP-L-fuc:Asn-linked GlcNAc alpha1,3-fucosyltransferase, GDP-L-fuc:N-acetyl-beta-D-glucosaminide alpha1,3-fucosyltransferase, LOC107797347, LOC107830046, NM_001324945, XM_016620229, XM_016657530

ECTree

     2 Transferases

         2.4 Glycosyltransferases

             2.4.1 Hexosyltransferases

                2.4.1.214 glycoprotein 3-alpha-L-fucosyltransferase

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Results	in table
4	Activating Compound
110	AA Sequence
3	Application
1	CAS Registry Number
25	Cloned(Commentary)
1	Crystallization (Commentary)
199	Disease/ Diagnostics
2	Expression
5	General Information
42	Inhibitors
2	kcat/KM [mM/s]
1	Ki Value [mM]
60	KM Value [mM]
4	Localization
32	Metals/Ions
15	Molecular Weight [Da]
23	Natural Substrates/ Products (Substrates)
44	Organism
3	Pathway
12	pH Optimum
4	pH Range
5	Posttranslational Modification
45	Protein Variants
8	Purification (Commentary)
2	Reaction
1	Reaction Type
40	Reference
46	Source Tissue
24	Specific Activity [micromol/min/mg]
94	Substrates and Products (Substrate)
11	Subunits
91	Synonyms
1	Systematic Name
10	Temperature Optimum [°C]
1	Temperature Range [°C]
1	Temperature Stability [°C]

General Information

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General Information on EC 2.4.1.214 - glycoprotein 3-alpha-L-fucosyltransferase

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GENERAL INFORMATION

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

malfunction

Mus musculus

-

suppression of isoform Fut10 expression induces the differentiation of neural stem cells and embryonic stem cells. In addition, enzyme knockdown in the cortical ventricular zone of the embryonic brain impairs the radial migration of neural precursor cells

736427

physiological function

4 entries

physiological function

Nicotiana benthamiana

-

an incomplete down-regulation of FucT activity is sufficient to allow the generation of immunoglobulin Gs carrying a glycan-optimized structure

694619

physiological function

Homo sapiens

Q11130

overexpression of FUT7 up-regulates sLeX synthesis and enhances sLeX-mediated embryo implantation. FUT7 overexpression enhances JAR cell adhesion to RL95-2 cells

703774

physiological function

Mus musculus

-

isoform Fut10 is required for the maintenance of stem cell populations. Enzyme overexpression enhances the self-renewal of neural stem cells

736427

physiological function

Nicotiana tabacum

A0A1S4AG82, A0A1S4DHZ6, D6RSA0

knocking-out of two XylT genes and four FucT genes in BY-2 suspension cells using CRISPR/Cas9. Three lines show a strong reduction of beta(1,2)-xylose and alpha(1,3)-fucose, while two lines are completely devoid of them, indicating complete gene inactivation. The KO lines do not show any particular morphology and grow as the wild-type. A KO line transformed with genes encoding a human IgG2 antibody shows an IgG2 expression level as high as in a control transformant. The IgG glycosylation profile shows no beta(1,2)-xylose or alpha(1,3)-fucose present on the glycosylation moiety. The dominant glycoform is the GnGn structure

756828