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2.4.1.214: glycoprotein 3-alpha-L-fucosyltransferase

This is an abbreviated version!
For detailed information about glycoprotein 3-alpha-L-fucosyltransferase, go to the full flat file.

Word Map on EC 2.4.1.214

Reaction

GDP-beta-L-fucose
+
N4-[beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc]-L-asparaginyl-[protein]
=
GDP
+
N4-[beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-[alpha-L-Fuc-(1->3)]-beta-D-GlcNAc]-L-asparaginyl-[protein]

Synonyms

alpha 1,3-fucosyltransferase VI, alpha(1,3)-fucosyltransferase VII, alpha(1,3)-fucosyltransferase-IV, alpha(1,3)-fucosyltransferase-VII, alpha(1,3)fucosyltransferase, alpha-1,3-fucosyltransferase-VII, alpha1,3-fucosyltransferase, alpha1,3-fucosyltransferase 10, alpha1,3-fucosyltransferase 7, alpha1,3-fucosyltransferase 9, alpha1,3-fucosyltransferase IX, alpha1,3FTs, alpha1-3 fucosyltransferase-VII, alpha3-fucosyltransferase, alpha3-FucT VII, AtFUT11, CEFT-1, CEFT-2, CEFT-3, CEFT-4, CEFT-5, CEFT3, core alpha-(1,3)-fucosyltransferase, core alpha1,3-fucosyltransferase, Fuc-T C3, Fuc-TVII, fucosyltransferase A, fucosyltransferase VII, FucT, FucT 115, FucT 45, FucT VI, FucT VII, FucT-IV, FucT-VII, FucT1, FucTA, FucTB, FucTC, FUT-1, FUT-6, FUT10, FUT11, FUT7, Fut9, GDP-fucose:beta-N-acetylglucosamine (Fuc to (Fuca1-6GlcNAc)-Asn-peptide) alpha1-3-fucosyltransferase, GDP-L-fuc:Asn-linked GlcNAc alpha1,3-fucosyltransferase, GDP-L-fuc:N-acetyl-beta-D-glucosaminide alpha1,3-fucosyltransferase, LOC107797347, LOC107830046, NM_001324945, XM_016620229, XM_016657530

ECTree

     2 Transferases
         2.4 Glycosyltransferases
             2.4.1 Hexosyltransferases
                2.4.1.214 glycoprotein 3-alpha-L-fucosyltransferase

Substrates Products

Substrates Products on EC 2.4.1.214 - glycoprotein 3-alpha-L-fucosyltransferase

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SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
GDP-alpha-L-fucose + fetuin
GDP + 3-alpha-L-fucosyl-fetuin
show the reaction diagram
-
-
-
-
?
GDP-alpha-L-fucose + Galbeta1-4GlcNAc-R
GDP + Galbeta1-4[Fucalpha1-3]GlcNAc-R
show the reaction diagram
-
-
-
-
ir
GDP-alpha-L-fucose + NeuAcalpha2-3Galbeta1-3GlcNAcbeta-R
GDP + NeuAcalpha2-3Galbeta1-3[Fucalpha1-3]GlcNAcbeta-R
show the reaction diagram
-
4% of the activity with NeuAcalpha2-3Galbeta1-4GlcNAc-R
-
-
?
GDP-alpha-L-fucose + NeuAcalpha2-3Galbeta1-4GlcNAc
GDP + NeuAcalpha2-3Galbeta1-4[Fucalpha1-3]GlcNAc
show the reaction diagram
-
28% of the activity with NeuAcalpha2-3Galbeta1-4GlcNAc-R
-
-
?
GDP-alpha-L-fucose + NeuAcalpha2-3Galbeta1-4GlcNAcbeta-R
GDP + NeuAcalpha2-3Galbeta1-4[Fucalpha1-3]GlcNAcbeta-R
show the reaction diagram
-
best substrate
-
-
?
GDP-beta-fucose + fetuin
GDP + fucosylated fetuin
show the reaction diagram
-
-
-
-
?
GDP-beta-L-fucose + (1->4)-beta-D-galactosyl-N-acetyl-D-glucosaminyl-L-Asn
GDP + (1->4)-beta-D-galactosyl-[alpha-(1->3)-L-fucosyl]-N-acetyl-D-glucosaminyl-L-Asn
show the reaction diagram
-
-
-
-
?
GDP-beta-L-fucose + GlcNAc-beta-(1->2)-Man-alpha-(1->6)-[GlcNAc-beta-(1->2)-Man-alpha-(1->3)]-Man-beta-(1->4)-GlcNAc-beta-(1->4)-[(Fuc-alpha-(1->6)]-GlcNAc-beta-(1->)-N?Asn?peptide
GDP + GlcNAc-beta-(1->2)-Man-alpha-(1->6)-[GlcNAc-beta-(1->2)-Man-alpha-(1->3)]-Man-beta-(1->4)-GlcNAc-beta-(1->4)-[(Fuc-alpha-(1->6)]-[(Fuc-alpha-(1->3)]-GlcNAc-beta-(1->)-N?Asn?peptide
show the reaction diagram
-
-
-
?
GDP-beta-L-fucose + GlcNAcbeta(1->2)Manalpha(1->6)(GlcNAcbeta(1-2)Manalpha(1->3))Manbeta(1->4)GlcNAcbeta(1->4)GlcNAc
GDP + GlcNAcbeta(1->2)Manalpha(1->6)(GlcNAcbeta(1->2)Manalpha(1->3))Manbeta(1->4)GlcNAcbeta(1->4)(Fucalpha(1->3))GlcNAc
show the reaction diagram
-
-
-
?
GDP-beta-L-fucose + GlcNAcbeta(1->2)Manalpha(1->6)(GlcNAcbeta(1->2)Manalpha(1->3))Manbeta(1->4)GlcNAcbeta(1->4)(ucalpha(1->6)G)cNAcbeta(1->)N-Asn-peptide(NAc)
?
show the reaction diagram
-
-
-
-
?
GDP-beta-L-fucose + GlcNAcbeta(1->2)Manalpha(1->6)[GlcNAcbeta(1->2)Manalpha(1->3)]Manbeta(1->4)GlcNAcbeta(1->4)GlcNAc
GDP + GlcNAcbeta(1->2)Manalpha(1->6)[GlcNAcbeta(1->2)Manalpha(1->3)]Manbeta(1->4)GlcNAcbeta(1->4)[L-Fucalpha(1->3)]GlcNAc
show the reaction diagram
-
-
-
-
?
GDP-beta-L-fucose + GlcNAcbeta(1->2)Manalpha(1->6)[GlcNAcbeta(1->2)Manalpha(1->3)]Manbeta(1->4)GlcNAcbeta(1->4)[L-Fucalpha(1->6)]GlcNAc
GDP + GlcNAcbeta(1->2)Manalpha(1->6)[GlcNAcbeta(1->2)Manalpha(1->3)]Manbeta(1->4)GlcNAcbeta(1->4)[L-Fucalpha(1->3)][L-Fucalpha(1->6)]GlcNAc
show the reaction diagram
GDP-beta-L-fucose + Manalpha(1->6)(Manalpha(1->3))Manalpha(1->6)(Manalpha(1->3))Manbeta(1->4)GlcNAcbeta(1->4)GlcNAc
GDP + Manalpha(1->6)(Manalpha(1->3))Manalpha(1->6)(Manalpha(1->3))Manbeta(1->4)GlcNAcbeta(1->4)[Fucalpha(1->3)]GlcNAc
show the reaction diagram
-
-
-
?
GDP-beta-L-fucose + Manalpha(1->6)[Manalpha(1->3)]Manbeta(1->4)GlcNAcbeta(1->4)[L-Fucalpha(1->6)]GlcNAc
GDP + Manalpha(1->6)[Manalpha(1->3)]Manbeta(1->4)GlcNAcbeta(1->4)[L-Fucalpha(1->3)][L-Fucalpha(1->6)]GlcNAc
show the reaction diagram
-
-
-
?
GDP-fucose + alpha1-acid glycoprotein
GDP + alpha1-3 fucosylated glycoprotein
show the reaction diagram
-
the activity of the LEC11 cells enzyme is considerably higher than the activity of the LEC12 cells enzyme
-
?
GDP-fucose + asialo-alpha1-acid glycoprotein
GDP + alpha1-3 fucosylated glycoprotein
show the reaction diagram
-
-
-
?
GDP-fucose + asialo/agalacto-glycopeptide-F2
GDP + alpha1-3-fucosylated glycopeptide
show the reaction diagram
-
asialo/agalacto-glycopeptide-F2: from human fibrinogen
-
?
GDP-fucose + asialo/agalacto-glycopeptide-IgGF6
GDP + alpha1-3-fucosylated glycopeptide
show the reaction diagram
-
asialo/agalacto-glycopeptide-IgGF6: from core alpha1-6-fucosylated human IgG
-
?
GDP-fucose + asialofetuin
GDP + alpha1-3 fucosylated glycoprotein
show the reaction diagram
-
-
-
?
GDP-fucose + asialotransferrin
GDP + alpha1-3 fucosylated glycoprotein
show the reaction diagram
-
-
-
?
GDP-fucose + bisected agalacto-glycopeptide-IgGF6
GDP + alpha1-3-fucosylated glycopeptide
show the reaction diagram
-
-
-
?
GDP-fucose + dabsyl-GnGn-peptide
GDP + alpha1-3-fucosylated dabsyl-GnGn-peptide
show the reaction diagram
GDP-fucose + dabsylated-GalGal-peptide
GDP + alpha1-3-fucosylated peptide
show the reaction diagram
-
0.7% relative activity with recombinant enzyme
-
?
GDP-fucose + dabsylated-GalGn-peptide
GDP + alpha1-3-fucosylated peptide
show the reaction diagram
-
50% relative activity with recombinant enzyme
-
?
GDP-fucose + dansyl-GnGn
GDP + alpha1-3-fucosylated glycopeptide
show the reaction diagram
GDP-fucose + dansyl-GnGnF6
GDP + alpha1-3-fucosylated glycopeptide
show the reaction diagram
-
prefucosylation of GnGn with chicken heart extract results in a superior conversion of GnGnF6 by FucTA than with GnGn, 100% relative conversion
-
?
GDP-fucose + dansylated mono-beta1,3-galactosylated glycopeptide
GDP + alpha1-3-fucosylated glycopeptide
show the reaction diagram
-
FucTA gene
-
?
GDP-fucose + fetuin
GDP + alpha1-3 fucosylated glycoprotein
show the reaction diagram
-
the activity of the LEC11 cells enzyme is considerably higher than the activity of the LEC12 cells enzyme
-
?
GDP-fucose + Galbeta1-4GlcNAcalpha-p-nitrophenol
Galbeta1-4(Fucalpha1-3)GlcNAcalpha-p-nitrophenol
show the reaction diagram
-
CFET-3 required no cations, CFET-4 required divalent cations
-
-
?
GDP-fucose + Galbeta1-4GlcNAcbeta1-3Galbeta1-4Glc
GDP + Galbeta1-4(Fucalpha1-3)GlcNAcbeta1-3Galbeta1-4Glc
show the reaction diagram
-
CFET-3 required no cations, CFET-4 required divalent cations
-
-
?
GDP-fucose + GalGal-N-glycan
GDP + alpha1-3-fucosylated GalGal-N-glycan
show the reaction diagram
-
4.6% relative conversion, FucTA gene
-
?
GDP-fucose + GalGalF6-N-glycan
GDP + alpha1-3-fucosylated GalGalF6-N-glycan
show the reaction diagram
-
19.8% relative conversion, FucTA gene
-
?
GDP-fucose + GalNAcbeta1-4GlcNAcbeta1-3Galbeta1-4Glc
GalNAcbeta1-4(Fucalpha1-3)GlcNAcbeta1-3Galbeta1-4Glc
show the reaction diagram
-
LDNT, CFET-2
-
-
?
GDP-fucose + GlcNAcbeta1-2-Manalpha1-3(GlcNAcbeta1-2Manalpha1-6)Manbeta1-4GlcNAcbeta1-4(Fucalpha1-6)GlcNAcbeta1-Asn
GDP + GlcNAcbeta1-2-Manalpha1-3(GlcNAcbeta1-2Manalpha1-6)Manbeta1-4GlcNAcbeta1-4(Fucalpha1-6)(Fucalpha1-3)GlcNAcbeta1-Asn
show the reaction diagram
-
-
-
?
GDP-fucose + GlcNAcbeta1-2-Manalpha1-3(GlcNAcbeta1-2Manalpha1-6)Manbeta1-4GlcNAcbeta1-4GlcNAcbeta1-Asn
GDP + GlcNAcbeta1-2-Manalpha1-3(GlcNAcbeta1-2Manalpha1-6)Manbeta1-4GlcNAcbeta1-4(Fucalpha1-3)GlcNAcbeta1-Asn
show the reaction diagram
-
-
-
?
GDP-fucose + GlcNAcbeta1-2-Manalpha1-3[Manalpha1-3(Manalpha1-6)Manalpha1-6]Manbeta1-4-GlcNAcbeta1-4GlcNAcbeta1-Asn
GDP + GlcNAcbeta1-2-Manalpha1-3[Manalpha1-3(Manalpha1-6)Manalpha1-6]Manbeta1-4-GlcNAcbeta1-4 (Fucalpha1-3)GlcNAcbeta1-Asn
show the reaction diagram
-
-
-
?
GDP-fucose + GlcNAcbeta1-2-Manalpha1-6(GlcNAcbeta1-2Manalpha1-3)Manbeta1-4GlcNAcbeta1-4(Fucalpha1-6)GlcNAcbeta1-N-Asn-peptide(Nac)
GDP + GlcNAcbeta1-2-Manalpha1-6(GlcNAcbeta1-2Manalpha1-3)Manbeta1-4GlcNAcbeta1-4(Fucalpha1-6)(Fucalpha1-3)GlcNAcbeta1-N-Asn-peptide(Nac)
show the reaction diagram
-
-
the product shows a difucosylated structure with two Fuc residues at the Asn-bound GlcNAc residue, 40% yield
?
GDP-fucose + GlcNAcbeta1-2Manalpha1-6(GlcNAcbeta1-2Manalpha1-3)Manbeta1-4(Fucalpha1-6)GlcNAcbeta1-Asn
GDP + GlcNAcbeta1-2Manalpha1-6(GlcNAcbeta1-2Manalpha1-3)Manbeta1-4GlcNAcbeta1-4(Fucalpha1-3)[Fucalpha1-6]GlcNAcbeta1-Asn
show the reaction diagram
-
difucosylated glycan structure
-
?
GDP-fucose + GlcNAcbeta1-2Manalpha1-6(GlcNAcbeta1-2Manalpha1-3)Manbeta1-4GlcNAcbeta1-Asn
GDP + GlcNAcbeta1-2Manalpha1-6(GlcNAcbeta1-2Manalpha1-3)Manbeta1-4(Fucalpha1-3)GlcNAcbeta1-Asn
show the reaction diagram
-
-
-
?
GDP-fucose + GnGn-oligosaccharide
GDP + alpha1-3 fucosylated GnGn-oligosaccharide
show the reaction diagram
-
93% relative activity of pure enzyme
-
?
GDP-fucose + GnGn-peptide
GDP + alpha1-3 fucosylated peptide
show the reaction diagram
-
100% relative activity of pure enzyme and of crude extract
-
?
GDP-fucose + GnGn-peptide
GDP + alpha1-3-fucosylated peptide
show the reaction diagram
-
100% relative activity with recombinant enzyme
-
?
GDP-fucose + GnGnF6-oligosaccharide
GDP + alpha1-3 fucosylated oligosaccharide
show the reaction diagram
-
95% relative activity of pure enzyme
-
?
GDP-fucose + GnGnF6-peptide
GDP + alpha1-3-fucosylated GnGnF6-peptide
show the reaction diagram
GDP-fucose + M5Gn-Asn
GDP + alpha1-3-fucosylated M5Gn-Asn
show the reaction diagram
-
71% relative activity with recombinant enzyme
-
?
GDP-fucose + Manalpha1-3(Manalpha1-6)Manbeta1-4GlcNAcbeta1-4(Fucalpha1-6)GlcNAcbeta1-Asn
Manalpha1-3(Manalpha1-6)Manbeta1-4GlcNAcbeta1-4(Fucalpha1-6)(Fucalpha1-3)GlcNAcb1-Asn
show the reaction diagram
-
CFET-1
-
-
?
GDP-fucose + Manalpha1-3(Manalpha1-6)Manbeta1-4GlcNAcbeta1-4GlcNAcbeta1-Asn
GDP + Manalpha1-3(Manalpha1-6)Manbeta1-4GlcNAcbeta1-4(Fucalpha1-3)GlcNAcbeta1-Asn
show the reaction diagram
-
CFET-1, Nglycan pentasaccharide core acceptor as substrate
-
-
?
GDP-fucose + N-acetyllactosamine
GDP + 3-fucosyl-N-acetyllactosamine
show the reaction diagram
-
-
-
?
GDP-fucose + N-acetyllactosamine
GDP + Galbeta1-4(Fucalpha1-3)GlcNAc
show the reaction diagram
GDP-fucose + N-[2-(2-pyridylamino)ethyl]-succinamic acid-labeled biantennary oligosaccharides
GDP + ?
show the reaction diagram
-
-
-
?
GDP-fucose + transferrin
GDP + alpha1-3 fucosylated glycoprotein
show the reaction diagram
-
-
-
?
GDP-L-Fuc + asparagine-linked N-acetyl-beta-D-glucosamine of asialo-agalacto-bi-antennary N-glycan
L-fucose alpha-1,3-bound to asparagine-linked N-acetyl-beta-D-glucosamine of asialo-agalacto-bi-antennary N-glycan + GDP
show the reaction diagram
-
-
-
?
GDP-L-fucose + GlcNAcbeta1,2Manalpha1,6(GlcNAcbeta1,2Manalpha1,3)Manbeta1,4GlcNAcbeta1,4(Fucalpha1,6)GlcNAc
GDP + GlcNAcbeta1,2Manalpha1,6(GlcNAcbeta1,2Manalpha1,3)Manbeta1,4GlcNAcbeta1,4(Fucalpha1,3)(Fucalpha1,6)GlcNAc
show the reaction diagram
-
preferred substrate
-
-
?
GDP-L-fucose + GlcNAcbeta1,2Manalpha1,6(GlcNAcbeta1,2Manalpha1,3)Manbeta1,4GlcNAcbeta1,4GlcNAc
GDP + GlcNAcbeta1,2Manalpha1,6(GlcNAcbeta1,2Manalpha1,3)Manbeta1,4GlcNAcbeta1,4(Fucalpha1,3)GlcNAc
show the reaction diagram
GDP-L-fucose + LacNAc-C8
GDP + alpha1,3-fucosylated LacNAc-C8
show the reaction diagram
-
-
-
-
?
GDP-L-fucose + N4-[N-acetyl-beta-D-glucosaminyl-(1-2)-alpha-D-mannosyl-(1-3)-[N-acetyl-beta-D-glucosaminyl-(1-2)-alpha-D-mannosyl-(1-6)]-beta-D-mannosyl-(1-4)-N-acetyl-beta-D-glucosaminyl-(1-4)-N-acetyl-beta-D-glucosaminyl]asparagine
GDP + N4-[N-acetyl-beta-D-glucosaminyl-(1-2)-alpha-D-mannosyl-(1-3)-[N-acetyl-beta-D-glucosaminyl-(1-2)-alpha-D-mannosyl-(1-6)]-beta-D-mannosyl-(1-4)-N-acetyl-beta-D-glucosaminyl-(1-4)-[alpha-L-fucosyl-(1-3)]-N-acetyl-beta-D-glucosaminyl]asparagine
show the reaction diagram
GDP-L-Gal + asparagine-linked N-acetyl-beta-D-glucosamine of asialo-agalacto-bi-antennary N-glycan
L-galactose bound to asparagine-linked N-acetyl-beta-D-glucosamine of asialo-agalacto-bi-antennary N-glycan + GDP
show the reaction diagram
-
-
-
?
additional information
?
-