2.4.1.217: mannosyl-3-phosphoglycerate synthase

This is an abbreviated version!
For detailed information about mannosyl-3-phosphoglycerate synthase, go to the full flat file.

Reaction

Synonyms

mannosyl-3-P-glycerate synthase, mannosyl-3-phosphoglycerate phosphatase, mannosyl-3-phosphoglycerate synthase, mannosyl-3-phosphoglycerate synthase/phosphatase, mannosylglycerate synthase, MGSD, MPG synthase, MPGP, MPGS, MPGS/GPGS, MpgS/P, synthase, mannosyl-3-phosphoglycerate

ECTree

     2 Transferases

         2.4 Glycosyltransferases

             2.4.1 Hexosyltransferases

                2.4.1.217 mannosyl-3-phosphoglycerate synthase

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Results	in table
1	Activating Compound
217	AA Sequence
1	CAS Registry Number
16	Cloned(Commentary)
5	Crystallization (Commentary)
23	General Information
1	General Stability
12	Inhibitors
21	KM Value [mM]
36	Metals/Ions
11	Molecular Weight [Da]
32	Natural Substrates/ Products (Substrates)
112	Organism
5	Pathway
30	PDB ID
13	pH Optimum
5	pH Range
1	Posttranslational Modification
3	Protein Variants
9	Purification (Commentary)
5	Reaction
3	Reaction Type
27	Reference
5	Specific Activity [micromol/min/mg]
52	Substrates and Products (Substrate)
18	Subunits
41	Synonyms
1	Systematic Name
13	Temperature Optimum [°C]
7	Temperature Range [°C]
18	Temperature Stability [°C]
2	Turnover Number [1/s]

Natural Substrates Products

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Natural Substrates Products on EC 2.4.1.217 - mannosyl-3-phosphoglycerate synthase

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NATURAL SUBSTRATE

NATURAL PRODUCT

REACTION DIAGRAM

ORGANISM

UNIPROT

COMMENTARY
(Substrate)

LITERATURE
(Substrate)

COMMENTARY
(Product)

LITERATURE
(Product)

REVERSIBILITY
r=reversible
ir=irreversible
?=not specified

GDP-glucose + 3-phospho-D-glycerate

GDP + 2-(alpha-D-glucosyl)-3-phosphoglycerate

Rubrobacter xylanophilus

-

-

736076

-

-

?

GDP-mannose + 3-phospho-D-glycerate

GDP + 2-(alpha-D-mannosyl)-3-phosphoglycerate

18 entries

GDPmannose + 3-phospho-D-glycerate

GDP + 2-(1-D-mannosyl)-3-phosphoglycerate

2 entries

additional information

?

-

10 entries

GDP-mannose + 3-phospho-D-glycerate

GDP + 2-(alpha-D-mannosyl)-3-phosphoglycerate

Dehalococcoides mccartyi

-

-

659043

-

-

?

GDP-mannose + 3-phospho-D-glycerate

GDP + 2-(alpha-D-mannosyl)-3-phosphoglycerate

Palaeococcus ferrophilus

-

-

736076

-

-

?

GDP-mannose + 3-phospho-D-glycerate

GDP + 2-(alpha-D-mannosyl)-3-phosphoglycerate

Palaeococcus ferrophilus

Q2VPS1

synthesis of mannosylglycerate proceeds via the two-step pathway comprising mannosyl-3-phosphoglycerate synthase and mannosyl-3-phosphoglycerate phosphatase (EC 3.1.3.70)

671435

-

-

?

GDP-mannose + 3-phospho-D-glycerate

GDP + 2-(alpha-D-mannosyl)-3-phosphoglycerate

Palaeococcus ferrophilus

Q2VPS1

the enzyme is involved in synthesis of mannosylglycerate

671435

-

-

?

GDP-mannose + 3-phospho-D-glycerate

GDP + 2-(alpha-D-mannosyl)-3-phosphoglycerate

Palaeococcus ferrophilus DSM 13482T

Q2VPS1

synthesis of mannosylglycerate proceeds via the two-step pathway comprising mannosyl-3-phosphoglycerate synthase and mannosyl-3-phosphoglycerate phosphatase (EC 3.1.3.70)

671435

-

-

?

GDP-mannose + 3-phospho-D-glycerate

GDP + 2-(alpha-D-mannosyl)-3-phosphoglycerate

Palaeococcus ferrophilus DSM 13482T

Q2VPS1

the enzyme is involved in synthesis of mannosylglycerate

671435

-

-

?

GDP-mannose + 3-phospho-D-glycerate

GDP + 2-(alpha-D-mannosyl)-3-phosphoglycerate

Pyrococcus horikoshii

-

-

736076

-

-

?

GDP-mannose + 3-phospho-D-glycerate

GDP + 2-(alpha-D-mannosyl)-3-phosphoglycerate

Pyrococcus horikoshii OT-3

-

-

736076

-

-

?

GDP-mannose + 3-phospho-D-glycerate

GDP + 2-(alpha-D-mannosyl)-3-phosphoglycerate

Rhodothermus marinus

-

-

736076

-

-

?

GDP-mannose + 3-phospho-D-glycerate

GDP + 2-(alpha-D-mannosyl)-3-phosphoglycerate

Rhodothermus marinus

Q6WSQ4

2 pathways for mannosylglycerate biosynthesis, a one-step and a two-step pathway, with specialized roles in osmoadaptation and thermoadaptation, the isozyme involved in the two-step pathway is upregulated by osmotic stress, the isozyme involved in the one-step pathway is upregulated by heat stress, regulatory mechanisms, overview

659444

-

-

?

GDP-mannose + 3-phospho-D-glycerate

GDP + 2-(alpha-D-mannosyl)-3-phosphoglycerate

Rubrobacter xylanophilus

-

-

736076

-

-

?

GDP-mannose + 3-phospho-D-glycerate

GDP + 2-(alpha-D-mannosyl)-3-phosphoglycerate

Rubrobacter xylanophilus

B7SY86

-

690271

-

-

?

GDP-mannose + 3-phospho-D-glycerate

GDP + 2-(alpha-D-mannosyl)-3-phosphoglycerate

Thermococcus litoralis

Q2VPR9

synthesis of mannosylglycerate proceeds via the two-step pathway comprising mannosyl-3-phosphoglycerate synthase and mannosyl-3-phosphoglycerate phosphatase (EC 3.1.3.70)

671435

-

-

?

GDP-mannose + 3-phospho-D-glycerate

GDP + 2-(alpha-D-mannosyl)-3-phosphoglycerate

Thermus thermophilus

-

-

701493, 736076

-

-

?

GDP-mannose + 3-phospho-D-glycerate

GDP + 2-(alpha-D-mannosyl)-3-phosphoglycerate

Thermus thermophilus

Q84B24

-

657584, 692253

-

-

?

GDP-mannose + 3-phospho-D-glycerate

GDP + 2-(alpha-D-mannosyl)-3-phosphoglycerate

Thermus thermophilus

-

-

692253

-

-

?

GDP-mannose + 3-phospho-D-glycerate

GDP + 2-(alpha-D-mannosyl)-3-phosphoglycerate

Thermus thermophilus HB27 / ATCC BAA-163 / DSM 7039

-

-

736076, 701493

-

-

?

GDP-mannose + 3-phospho-D-glycerate

GDP + 2-(alpha-D-mannosyl)-3-phosphoglycerate

Thermus thermophilus HB27 / ATCC BAA-163 / DSM 7039

Q84B24

-

657584

-

-

?

GDPmannose + 3-phospho-D-glycerate

GDP + 2-(1-D-mannosyl)-3-phosphoglycerate

Pyrococcus horikoshii

-

involved in a pathway for synthesis of mannosylglycerate

393092

mannosyl-3-phosphoglycerate is subsequently dephosphorylated by a specific phosphatase, EC 3.1.3.70, producing mannosylglycerate

393092

?

GDPmannose + 3-phospho-D-glycerate

GDP + 2-(1-D-mannosyl)-3-phosphoglycerate

Rhodothermus marinus

-

involved in a pathway for synthesis of mannosylglycerate

393091

-

393091

?

additional information

?

-

Dehalococcoides mccartyi

-

the bifunctional enzyme catalyzes the consecutive synthesis and dephosphorylation of mannosyl-3-phosphoglycerate in mannosylglycerate biosynthesis, enzyme evolution

659043

-

-

?

additional information

?

-

Palaeococcus ferrophilus

-

all MPGSs have high affinity for GDP-mannose and 3-D-phosphoglycerate

736076

-

-

?

additional information

?

-

Pyrococcus horikoshii

-

all MPGSs have high affinity for GDP-mannose and 3-D-phosphoglycerate

736076

-

-

?

additional information

?

-

Pyrococcus horikoshii OT-3

-

all MPGSs have high affinity for GDP-mannose and 3-D-phosphoglycerate

736076

-

-

?

additional information

?

-

Rhodothermus marinus

Q6WSQ4

the 30 amino acid C-terminal sequence of the enzyme has regulatory function, cleaving of this peptide increases the activity by 10fold

659444

-

-

?

additional information

?

-

Rhodothermus marinus

-

the 30 amino acid C-terminal sequence of the enzyme has regulatory function, cleaving of this peptide increases the activity by 10fold

659444

-

-

?

additional information

?

-

Rhodothermus marinus

-

all MPGSs have high affinity for GDP-mannose and 3-D-phosphoglycerate

736076

-

-

?

additional information

?

-

Rubrobacter xylanophilus

-

all MPGSs have high affinity for GDP-mannose and 3-D-phosphoglycerate. The enzyme from Rubrobacter xylanophilus is promiscuous and produces the phosphorylated form of glucosylglycerate (GPG) from GDP-glucose plus 3-D-phosphoglycerate with high efficiency. In spite of the less favorable parameters for the synthesis of mannosylglycerate, this is the only free glyceryl glycoside found in Rubrobacter xylanophilus cells

736076

-

-

?

additional information

?

-

Thermus thermophilus

-

all MPGSs have high affinity for GDP-mannose and 3-D-phosphoglycerate. Substrate binding structure, overview

736076

-

-

?

additional information

?

-

Thermus thermophilus HB27 / ATCC BAA-163 / DSM 7039

-

all MPGSs have high affinity for GDP-mannose and 3-D-phosphoglycerate. Substrate binding structure, overview

736076

-

-

?