2.4.1.218: hydroquinone glucosyltransferase
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For detailed information about hydroquinone glucosyltransferase, go to the full flat file.
Reaction
Synonyms
arbutin synthase, arbutin synthetase, AS, glucosyltransferase, uridine diphosphoglucose-hydroquinone, hydroquinone glucosyl transferase, hydroquinone O-glucosyltransferase, hydroquinone:O-glucosyltransferase, More, uridine diphosphate-glucose:hydroquinone glucosyltransferase
ECTree
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Application
Application on EC 2.4.1.218 - hydroquinone glucosyltransferase
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synthesis
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formation of arbutin, which is a potent inhibitor of human melanin biosynthesis with commercial value
synthesis
an artificial pathway is established in Escherichia coli for high-level production of arbutin from simple carbon sources in Escherichia coli for high-level production of arbutin from simple carbon sources. Introduction of the genes for 4-hydroxybenzoate 1-hydroxylase from Candida parapsilosis CBS604 and hydroquinone glucosyltransferase from Rauvolfia serpentina into Escherichia coli leads to the production of 54.71 mg/l of arbutin from glucose. Further redirection of carbon flux into arbutin biosynthesis pathway by enhancing shikimate pathway genes enables production of 3.29 g/l arbutin. Final optimization of glucose concentration added in the culture medium is able to further improve the titer of arbutin to 4.19 g/l in shake flasks experiments