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2.4.1.22: lactose synthase

This is an abbreviated version!
For detailed information about lactose synthase, go to the full flat file.

Word Map on EC 2.4.1.22

Reaction

UDP-alpha-D-galactose
+
D-glucose
=
UDP
+
lactose

Synonyms

alpha-lactalbumin, B4GALT1, beta-1,4-galactosyltransferase, beta-1,4-galactosyltransferase 1, beta-GalT, beta1,4-galactosyltransferase, beta1,4-galactosyltransferase-1, beta1,4-galactosyltransferase1, beta4Gal-T1, c-LacdiNAcS, Gal-T1, GalNAc(beta1-4)GlcNAc synthase, GALT, glactosyltransferase, uridine diphosphogalactose-glucose, GT, HP0826, lacdiNAc, LACS, lactose synthase, lactose synthetase, LALBA, LALBA1, LgtB, More, N-acetyllactosamine synthase, UDP-galactose-glucose galactosyltransferase, UDPgalactose-glucose galactosyltransferase, UGT72B1

ECTree

     2 Transferases
         2.4 Glycosyltransferases
             2.4.1 Hexosyltransferases
                2.4.1.22 lactose synthase

Inhibitors

Inhibitors on EC 2.4.1.22 - lactose synthase

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INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
2,4,6-Trinitrobenzenesulfonate
-
modification of alpha-lactalbumin
2-deoxy-D-glucose
-
0.4 M, 68% inhibition
2-Hydroxy-5-nitrobenzyl bromide
-
modification of alpha-lactalbumin
2-mercaptoethanol
-
modification of alpha-lactalbumin
2-Nitrophenylsulfenyl chloride
-
modification of alpha-lactalbumin
acetone
-
20% v/v, 69% inhibition
acetonitrile
-
20% v/v, complete inhibition
alpha-lactalbumin
-
inhibits galactosyl transfer to N-acetylglucosamine
-
Ca2+
-
above 4 mM
carbodiimide
-
at pH 4.5 rapid loss of the biological activity of alpha-lactalbumin
D-arabinose
-
0.4 M, 13% inhibition
D-ribose
-
0.4 M, 59% inhibition
D-xylose
-
0.4 M, 36% inhibition
Dimethyl-(2-hydroxy-5-nitrobenzyl)-sulfonium bromide
-
modification of alpha-lactalbumin
Dimethylsulfoxide
-
20% v/v, 43% inhibition
dioxane
-
20% v/v, 88% inhibition
dithiothreitol
-
the rate of reduction of the disulfide bond in alpha-lactalbumin is much faster with dithiothreitol than mercaptoethanol, and at 24°C proceeds to completion within minutes at pH 8
ethanol
-
20% v/v, 4% inhibition
Formylkynurenine
glycinamide
-
at pH 4.5 rapid loss of the biological activity of alpha-lactalbumin
Iodine
-
-
iodoacetate
L-arabinose
-
0.4 M, 54% inhibition
L-sorbose
-
0.4 M, 45% inhibition
L-Xylose
-
0.4 M, 16% inhibition
Maleic anhydride
-
-
Mg2+
-
above 4 mM
N,N-Dimethylformamide
-
20% v/v, 90% inhibition
N-Acetylimidazole
N-methylpyrrolidone
-
20% v/v, complete inhibition
tetrahydrofuran
-
20% v/v, complete inhibition
Tetranitromethane
-
-
tunicamycin
-
-
UDPglucose
-
-
vincristine
-
-
additional information
-