2.4.1.22: lactose synthase
This is an abbreviated version!
For detailed information about lactose synthase, go to the full flat file.
Word Map on EC 2.4.1.22
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2.4.1.22
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milk
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beta-lactoglobulin
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whey
-
casein
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lysozyme
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globule
-
molten
-
beta-casein
-
oligosaccharide
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lactoferrin
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prolactin
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goat
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n-acetylglucosamine
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infant
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dairy
-
immunoglobulin
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n-glycans
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galactosylation
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sialylated
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kappa-caseins
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ovalbumin
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alpha-casein
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bsa
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beta-lg
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native-like
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allergy
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glycosyltransferases
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ca2+-binding
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refolding
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complex-type
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lactoperoxidase
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wallaby
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intramammary
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macropus
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beta-domain
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udder
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apomyoglobin
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cheese
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breast-fed
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virgin
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globule-like
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n-acetyllactosamine
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formula-fed
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alpha-crystallin
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skim
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fucosylated
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egg-white
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lactogen
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colostrum
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glycoconjugates
- 2.4.1.22
- milk
- beta-lactoglobulin
- whey
- casein
- lysozyme
-
globule
-
molten
- beta-casein
- oligosaccharide
- lactoferrin
- prolactin
- goat
- n-acetylglucosamine
- infant
-
dairy
- immunoglobulin
- n-glycans
-
galactosylation
-
sialylated
- kappa-caseins
- ovalbumin
- alpha-casein
- bsa
-
beta-lg
-
native-like
- allergy
- glycosyltransferases
-
ca2+-binding
-
refolding
-
complex-type
- lactoperoxidase
- wallaby
-
intramammary
- macropus
-
beta-domain
-
udder
- apomyoglobin
-
cheese
-
breast-fed
-
virgin
-
globule-like
- n-acetyllactosamine
-
formula-fed
- alpha-crystallin
-
skim
-
fucosylated
-
egg-white
-
lactogen
- colostrum
- glycoconjugates
Reaction
Synonyms
alpha-lactalbumin, B4GALT1, beta-1,4-galactosyltransferase, beta-1,4-galactosyltransferase 1, beta-GalT, beta1,4-galactosyltransferase, beta1,4-galactosyltransferase-1, beta1,4-galactosyltransferase1, beta4Gal-T1, c-LacdiNAcS, Gal-T1, GalNAc(beta1-4)GlcNAc synthase, GALT, glactosyltransferase, uridine diphosphogalactose-glucose, GT, HP0826, lacdiNAc, LACS, lactose synthase, lactose synthetase, LALBA, LALBA1, LgtB, More, N-acetyllactosamine synthase, UDP-galactose-glucose galactosyltransferase, UDPgalactose-glucose galactosyltransferase, UGT72B1
ECTree
2.4.1.22 lactose synthaseAdvanced search results
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results (Substrates Products
Substrates Products on EC 2.4.1.22 - lactose synthase
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SUBSTRATE 
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
alpha-UDP-D-galactose + D-glucose
UDP + lactose
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inversion of anomeric configuration to form beta-O-galactosides
-
-
?
alpha-UDP-D-galactose + N-acetyl-D-glucosamine
UDP + alpha-D-galactosyl(1-4)beta-N-acetyl-D-glucosamine
-
-
-
-
?
UDP-alpha-D-galactose + O-beta-D-xylosyl-[IgG antibody]
UDP + 4-beta-D-galactosyl-O-beta-D-xylosyl-[IgG antibody]
antibody (Lo-BM2) expressed in Nicotiana tabacum strain BY-2 cells
-
-
?
UDP-D-galactose + D-glucose
UDP + lactose
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lactose synthesis is achieved only in the presence of alpha-lactalbumin. In absence of alpha-lactalbumin the enzyme catalyzes the reaction of EC 2.4.1.90
-
-
?
UDP-glucose + N-acetyl-D-glucosamine
UDP + D-glucosyl(1-4)beta-N-acetyl-D-glucosamine
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about 20% activity compared to UDP-galactose
-
-
?
dUDPgalactose + D-glucose
lactose + dUDP
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dUDPgalactose is 80% as effective as UDP-D-galactose
-
-
?
UDP-galactose + D-glucose
UDP + lactose
-
-
-
?
UDP-galactose + D-glucose
UDP + lactose
residues necessary for lactose synthesis activity are Phe31, His32, Leu110, Gln117 and Trp118 of alpha-lactalbumin
-
-
?
UDP-galactose + D-glucose
UDP + lactose
residues necessary for lactose synthesis activity are Phe31, His32, Leu110, Gln117 and Trp118 of alpha-lactalbumin
-
-
?
UDP-galactose + D-glucose
UDP + lactose
residues necessary for lactose synthesis activity are Phe31, His32, Leu110, Gln117 and Trp118 of alpha-lactalbumin
-
-
?
UDP-galactose + D-glucose
UDP + lactose
residues necessary for lactose synthesis activity are Phe31, His32, Leu110, Gln117 and Trp118 of alpha-lactalbumin
-
-
?
UDP-galactose + D-glucose
UDP + lactose
residues necessary for lactose synthesis activity are Phe31, His32, Leu110, Gln117 and Trp118 of alpha-lactalbumin
-
-
?
UDP-galactose + D-glucose
UDP + lactose
residues necessary for lactose synthesis activity are Phe31, His32, Leu110, Gln117 and Trp118 of alpha-lactalbumin
-
-
?
UDP-galactose + D-glucose
UDP + lactose
residues necessary for lactose synthesis activity are Phe31, His32, Leu110, Gln117 and Trp118 of alpha-lactalbumin
-
-
?
UDP-galactose + D-glucose
UDP + lactose
residues necessary for lactose synthesis activity are Phe31, His32, Leu110, Gln117 and Trp118 of alpha-lactalbumin
-
-
?
UDP-galactose + N-acetyl-D-glucosamine
UDP + D-galactosyl(1-4)beta-N-acetyl-D-glucosamine
-
-
-
-
?
UDP-galactose + N-acetyl-D-glucosamine
UDP + D-galactosyl(1-4)beta-N-acetyl-D-glucosamine
-
-
-
-
?
UDP-galactose + N-acetyl-D-glucosamine
UDP + D-galactosyl(1-4)beta-N-acetyl-D-glucosamine
-
-
-
-
?
UDPgalactose + D-glucose
lactose + UDP
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the galactosyl transferase can catalyze the transfer of galactose to glucose to form lactose in the absence of alpha-lactalbumin provided the glucose concentration is high
-
-
?
additional information
?
-
-
upon substrate binding to beta4Gal-T1, a large conformational change occurs in the region comprising residues 345 to 365. The role of alpha-lactalbumin is to hold glucose by hydrogen bonding with the O-1 hydroxyl group in the acceptor-binding site on beta4Gal-T1, while the N-acetyl group-binding pocket in beta4Gal-T1 adjusts to maximize the interactions with the glucose molecule
-
-
?
additional information
?
-
-
molecular interaction with different donor substrates, overview, the enzyme undergoes transition from open to close conformation upon binding of donor or acceptor substrate, overview
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-
?
additional information
?
-
-
c-LacdiNAcS is auto-lacdiNAcylated and can synthesize GalNAc(beta1-4)GlcNAc structures on cellular glycoproteins
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-
?
additional information
?
-
-
acceptor substrate specificity, no activity with D-galactose, N-acetylgalactosamine, glucosamine, and lactose as acceptor substrates, no activity with UDP-glucose as donor substrate, overview
-
-
?
additional information
?
-
the enzyme interacts with UDP-galactose transporter SLC35A2
-
-
-
additional information
?
-
-
upon substrate binding to beta4Gal-T1, a large conformational change occurs in the region comprising residues 345 to 365. The role of alpha-lactalbumin is to hold glucose by hydrogen bonding with the O-1 hydroxyl group in the acceptor-binding site on beta4Gal-T1, while the N-acetyl group-binding pocket in beta4Gal-T1 adjusts to maximize the interactions with the glucose molecule
-
-
?
additional information
?
-
-
acceptor substrate specificity, no activity with D-galactose, N-acetylgalactosamine, glucosamine, and lactose as acceptor substrates, overview
-
-
?
additional information
?
-
-
beta1,4-galactosyltransferase-I forms a complex with alpha-lactalbumin to give lactose synthase
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-
?
