2.4.1.222: O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase
This is an abbreviated version!
For detailed information about O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase, go to the full flat file.
Word Map on EC 2.4.1.222
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2.4.1.222
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notch
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glycosyltransferases
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somite
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mesoderm
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n-glycans
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presomitic
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n-acetylglucosamine
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somitogenesis
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udp-n-acetylglucosamine
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galactosyltransferase
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delta1
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jagged1
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paraxial
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dll1
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delta-like
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bisect
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fucose-specific
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unsegmented
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o-fucosylation
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n-acetyllactosamine
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o-mannose
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glcnac-ts
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delta-notch
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n-acetylglucosaminylated
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pomgnt1s
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poly-n-acetyllactosamine
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o-fucosyltransferase
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tetraantennary
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gnt-ivs
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o-mannosylated
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synthesis
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medicine
- 2.4.1.222
- notch
- glycosyltransferases
- somite
- mesoderm
- n-glycans
-
presomitic
- n-acetylglucosamine
-
somitogenesis
- udp-n-acetylglucosamine
-
galactosyltransferase
-
delta1
-
jagged1
-
paraxial
- dll1
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delta-like
-
bisect
-
fucose-specific
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unsegmented
-
o-fucosylation
- n-acetyllactosamine
-
o-mannose
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glcnac-ts
-
delta-notch
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n-acetylglucosaminylated
- pomgnt1s
- poly-n-acetyllactosamine
-
o-fucosyltransferase
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tetraantennary
- gnt-ivs
-
o-mannosylated
- synthesis
- medicine
Reaction
Synonyms
acetylglucosaminylferase, uridine diphosphoacetylglucosamine:fucosyglycoprotein beta1-3-, beta-1,3-N-acetyl-glucosaminyltransferase, beta-1,3-N-acetylglucosaminyltransferase, beta1,3-acetylglucosaminyltransferase, beta1,3-N-acetylglucosaminyltransferase, beta1,3-N-acetylglucosaminyltransferase-2, beta1,3-N-acetylglusoaminyltransferase, Dfng, FNG, Fringe, fringe beta1,3 N-acetylglucosaminyltransferase, fringe glycosyltransferase, Fringe O-fucose-beta1,3-N-acetylglucosaminyltransferase, Fringe protein, glycosyltransferase Fringe, LFNG, Lunatic Fringe, lunatic fringe glycosyltransferase, Maniac Fringe, Manic fringe, manic fringe glycosyltransferase, MFng, N-acetylglucosaminyltransferase, O-fucose-beta1,3-N-acetylglucosaminyltransferase, O-fucosylpeptide beta-1,3-N-acetylglucosaminyltransferase, O-fucosylpeptide-3-beta-N-acetylglucosaminyltransferase, Radical Fringe, radical fringe glycosyltransferase, Rfng, UDP-acetylglucosamine:fucosylglycoprotein, UDP-D-GlcNAc:O-L-fucosylpeptide 3-beta-N-acetyl-D-glucosaminyltransferase, UDP-GlcNAc:fucose beta1,3 N-acetylglucosaminyltransferase, UDP-glucose:O-linked fucose beta1,3-glucosyltransferase
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2.4.1.222 O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferaseAdvanced search results
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results (Natural Substrates Products
Natural Substrates Products on EC 2.4.1.222 - O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase
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NATURAL SUBSTRATE 
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
UDP-GlcNAc + Notch epidermal growth factor-like sequence repeat-O-fucose
UDP + ?
Drosophila sp. (in: flies)
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the enzyme (Fringe) regulates fly Notch signaling by adding GlcNAc to O-fucose on Notch epidermal growth factor-like sequence repeats EGF8, -9, and -12
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-
?
[Notch]-fucose + UDP-alpha-D-N-acetylglucosamine
[Notch]-(3-O-beta-D-N-acetylglucosaminyl)fucose + UDP
Notch + UDP-D-GlcNAc
beta-D-glucosaminyl-Notch + UDP
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enzyme completely inhibits binding of Notch protein to its serrate ligands by capping of O-fucose sites, regulation of enzyme activity via expression level in correspondance to the expression level of protein O-fucosyltransferase
-
-
?
Notch + UDP-D-GlcNAc
beta-D-glucosaminyl-Notch + UDP
enzyme modulates signaling through Notch receptors by modifying O-linked fucose on epidermal growth factor-like domains
-
-
?
Notch + UDP-D-GlcNAc
beta-D-glucosaminyl-Notch + UDP
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enzyme plays a key role in the specification of boundaries during development by modulating the ability of Notch ligands to activate Notch receptors
-
-
?
Notch + UDP-D-GlcNAc
beta-D-glucosaminyl-Notch + UDP
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Fringe and protein O-fucosyltransferase regulate Notch signaling via binding to cell surface Notch receptors, overview
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-
?
Notch + UDP-D-GlcNAc
beta-D-glucosaminyl-Notch + UDP
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glycosylation of Notch enables it to activate signaling through binding to Delta ligand required for the specification of secondary mesenchym cells, loss of enzyme delays ectoderm patterning
-
-
?
Notch + UDP-D-GlcNAc
beta-D-glucosaminyl-Notch + UDP
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different enzyme forms, glycosylation of Notch modulates its binding to different receptors, e.g. binding to Serrate is decreased, while binding to Delta is enhanced, the enzyme thereby inhibits or activates signaling, Fringe proteins differentially modulate ligand-induced proteolysis of Notch1
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-
?
[Notch]-fucose + UDP-alpha-D-N-acetylglucosamine
[Notch]-(3-O-beta-D-N-acetylglucosaminyl)fucose + UDP
-
-
-
-
?
[Notch]-fucose + UDP-alpha-D-N-acetylglucosamine
[Notch]-(3-O-beta-D-N-acetylglucosaminyl)fucose + UDP
-
-
-
-
?
[Notch]-fucose + UDP-alpha-D-N-acetylglucosamine
[Notch]-(3-O-beta-D-N-acetylglucosaminyl)fucose + UDP
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Fringe genes encode beta-1,3-N-acetyl-glucosaminyltransferases, which elongate O-fucose on the EGF repeat of Notch and its ligands
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-
?
[Notch]-fucose + UDP-alpha-D-N-acetylglucosamine
[Notch]-(3-O-beta-D-N-acetylglucosaminyl)fucose + UDP
-
-
-
-
?
additional information
?
-
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transfers a beta-D-GlcNAc residue from UDP-D-GlcNAc to the fucose residue of a fucosylated protein acceptor
-
-
?
additional information
?
-
-
transfers a beta-D-GlcNAc residue from UDP-D-GlcNAc to the fucose residue of a fucosylated protein acceptor
-
-
?
additional information
?
-
-
transfers a beta-D-GlcNAc residue from UDP-D-GlcNAc to the fucose residue of a fucosylated protein acceptor
-
-
?
additional information
?
-
-
transfers a beta-D-GlcNAc residue from UDP-D-GlcNAc to the fucose residue of a fucosylated protein acceptor
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-
?
additional information
?
-
-
O-GlcNAc is added to Notch by an enzymatic activity distinct from the well-known nuclear/cytoplasmic O-GlcNAc transferase, OGT, EC 2.4.1.255
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-
?
additional information
?
-
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Drosophila Fringe glycosyltransferase adds GlcNAc specifically to the O-fucose residues of Notch transmembrane proteins
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-
?
additional information
?
-
Drosophila sp. (in: flies)
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Fringe is required for the differentiation of polar cell precursors. Fringe is necessary for generating positional information in localizing a high-affinity interaction between Notch and its ligand Delta, even if a second ligand is not essential
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-
?
additional information
?
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Drosophila sp. (in: flies)
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the glycosyltransferase Fringe promotes Delta-Notch signaling between neurons and glia, and is required for subtype-specific glial gene expression
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-
?
additional information
?
-
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transfers a beta-D-GlcNAc residue from UDP-D-GlcNAc to the fucose residue of a fucosylated protein acceptor
-
-
?
additional information
?
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the enzyme adds N-acetylglucosamine to O-linked fucose residues on epidermal growth factor repeats of Notch
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-
?
additional information
?
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the enzyme adds N-acetylglucosamine to O-linked fucose residues on epidermal growth factor repeats of Notch
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-
?
additional information
?
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the enzyme modifies EGF repeats in the Notch extracellular domain
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-
?
additional information
?
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the enzyme modifies EGF repeats in the Notch extracellular domain
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-
?
additional information
?
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the enzyme transfers beta-D-N-acetylglucosaminyl residues to EGF repeats of Notch proteins, Notch receptors and ligands are transmembrane proteins
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-
?
additional information
?
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the enzyme transfers beta-D-N-acetylglucosaminyl residues to EGF repeats of Notch proteins, Notch receptors and ligands are transmembrane proteins
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-
?
additional information
?
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the enzyme transfers beta-D-N-acetylglucosaminyl residues to EGF repeats of Notch proteins, Notch receptors and ligands are transmembrane proteins
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-
?
additional information
?
-
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transfers a beta-D-GlcNAc residue from UDP-D-GlcNAc to the fucose residue of a fucosylated protein acceptor
-
-
?
additional information
?
-
-
Fringe elongates O-fucose residues on EGF-like repeat 4 and 5 of Notch3. Fringe plays a role in CADASIL pathophysiology
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-
?
additional information
?
-
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transfers a beta-D-GlcNAc residue from UDP-D-GlcNAc to the fucose residue of a fucosylated protein acceptor
-
-
?
additional information
?
-
-
transfers a beta-D-GlcNAc residue from UDP-D-GlcNAc to the fucose residue of a fucosylated protein acceptor
-
-
?
additional information
?
-
-
LFNG, Lunatic Fringe, and MFNG, Manic Fringe, transfer N-acetylglucosamine (GlcNAc) to O-fucose attached to EGF-like repeats of NOTCH receptors
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-
?
additional information
?
-
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O-GlcNAc is added to Notch by an enzymatic activity distinct from the well-known nuclear/cytoplasmic O-GlcNAc transferase, OGT, EC 2.4.1.255
-
-
?
additional information
?
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the enzyme adds N-acetylglucosamine to O-linked fucose residues on epidermal growth factor repeats of Notch. Lfng inhibits activation of Notch1 and Notch4 in basal cells of the mouse prostate gland while enhancing Notch3 activation
-
-
?
additional information
?
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the enzyme interacts with Delta-like 3 (DLL3), a member of the DSL family of Notch ligands, epidermal growth factor like repeats 2 and 5 of DLL3 are O-fucosylated at consensus sites for peptide-O-fucosyltransferase POFUT1, EC 2.4.1.221
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-
?
additional information
?
-
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the enzyme interacts with Delta-like 3 (DLL3), a member of the DSL family of Notch ligands, epidermal growth factor like repeats 2 and 5 of DLL3 are O-fucosylated at consensus sites for peptide-O-fucosyltransferase POFUT1, EC 2.4.1.221
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-
?
additional information
?
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ligand-receptor interactions and role of fringe glycosylation, regulation of signaling, overview, Fringe proteins do not influence the surface expression of Notch1
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-
?
