2.4.1.223: glucuronosyl-galactosyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase

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For detailed information about glucuronosyl-galactosyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase, go to the full flat file.

Word Map on EC 2.4.1.223

2.4.1.223

heparan

proteoglycans

glycosyltransferases

ext-like

glycosaminoglycans

extls

chondroitin

exostosins

mucous

n-acetylgalactosamine

tetrasaccharide

wingless

decapentaplegic

brunner

heparitinase

pancreaticobiliary

hspgs

fam20b

Reaction

[protein]-3-O-(beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl)-L-serine

[protein]-3-O-(alpha-D-GlcNAc-(1->4)-beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl)-L-serine

Synonyms

alpha-N-acetylglucosaminyltransferase I, alpha1,4-N-acetylglucosaminyltransferase, botv, brother of tout-velu, Exostosin-like 2, EXTL2, EXTL3, Galntl-1, glucuronosylgalactosylproteoglycan 4-alpha-N-acetylglucosaminyltransferase, N-acetylgalactosaminyltransferase-like 1

ECTree

2 Transferases

2.4 Glycosyltransferases

2.4.1 Hexosyltransferases

2.4.1.223 glucuronosyl-galactosyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase

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Results	in table
37	AA Sequence
2	CAS Registry Number
4	Cloned(Commentary)
43	Disease/ Diagnostics
4	Expression
2	General Information
1	Inhibitors
3	Localization
4	Natural Substrates/ Products (Substrates)
11	Organism
3	Pathway
4	PDB ID
2	Protein Variants
2	Purification (Commentary)
1	Reaction
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10	Reference
11	Source Tissue
20	Substrates and Products (Substrate)
11	Synonyms
1	Systematic Name
1	Temperature Stability [°C]

Localization

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Localization on EC 2.4.1.223 - glucuronosyl-galactosyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase

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endoplasmic reticulum

Drosophila melanogaster

5783

661562

Golgi apparatus

Drosophila melanogaster

human EXTL3 is inserted into the Golgi apparatus membrane by an N-terminal transmembrane helix of 20 residues, followed by an unstructured protein segment of about 18 residues, rich in charged amino acids, and then around 80 residues of coiled-coil structure that may play a role in positioning and/or orienting the following catalytic domains on the Golgi membrane

16020

758808