2.4.1.223: glucuronosyl-galactosyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase
This is an abbreviated version!
For detailed information about glucuronosyl-galactosyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase, go to the full flat file.
Word Map on EC 2.4.1.223
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2.4.1.223
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heparan
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proteoglycans
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glycosyltransferases
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ext-like
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glycosaminoglycans
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extls
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chondroitin
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exostosins
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mucous
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n-acetylgalactosamine
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tetrasaccharide
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wingless
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decapentaplegic
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brunner
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heparitinase
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pancreaticobiliary
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hspgs
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fam20b
- 2.4.1.223
- heparan
- proteoglycans
- glycosyltransferases
-
ext-like
- glycosaminoglycans
-
extls
- chondroitin
- exostosins
-
mucous
- n-acetylgalactosamine
- tetrasaccharide
-
wingless
-
decapentaplegic
-
brunner
- heparitinase
-
pancreaticobiliary
-
hspgs
-
fam20b
Reaction
Synonyms
alpha-N-acetylglucosaminyltransferase I, alpha1,4-N-acetylglucosaminyltransferase, botv, brother of tout-velu, Exostosin-like 2, EXTL2, EXTL3, Galntl-1, glucuronosylgalactosylproteoglycan 4-alpha-N-acetylglucosaminyltransferase, N-acetylgalactosaminyltransferase-like 1
ECTree
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Systematic Name
Systematic Name on EC 2.4.1.223 - glucuronosyl-galactosyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase
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UDP-N-acetyl-alpha-D-glucosamine:[protein]-3-O-(beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl)-L-serine 4IV-alpha-N-acetyl-D-glucosaminyltransferase (configuration-retaining)
Enzyme involved in the initiation of heparin and heparan sulfate synthesis, transferring GlcNAc to the (GlcA-Gal-Gal-Xyl-)Ser core. Apparently products of both the human EXTL2 and EXTL3 genes can catalyse this reaction. In Caenorhabditis elegans, the product of the rib-2 gene displays this activity as well as that of EC 2.4.1.224, glucuronosyl-N-acetylglucosaminyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase. For explanation of the use of a superscript in the systematic name, see {iupac/2carb/37#372::2-Carb-37.2}.