2.4.1.225: N-acetylglucosaminyl-proteoglycan 4-beta-glucuronosyltransferase This is an abbreviated version! For detailed information about N-acetylglucosaminyl-proteoglycan 4-beta-glucuronosyltransferase, go to the full flat file .
Reaction
UDP-alpha-D-glucuronate +
N-acetyl-alpha-D-glucosaminyl-(1->4)-beta-D-glucuronosyl-proteoglycan =
UDP +
beta-D-glucuronosyl-(1->4)-N-acetyl-alpha-D-glucosaminyl-(1->4)-beta-D-glucuronosyl-proteoglycan
Synonyms diphosphoglucuronate:oligosaccharide uridine glucuronosyltransferase, exostosin, exostosin-1, exostosin-2, Exostosin1, Exostosin2, exotose-2, EXT-1, EXT-2, EXT-3, EXT1, EXT2, EXTL3, extosin, gene EXTL1 glycosyltransferase, gene EXTL2 glycosyltransferase, glucuronic acid/N-acetylglucosamine co-polymerase-1, glucuronosyltransferase, heparan glucuronosyltransferase II, heparan sulfate co-polymerase, heparan sulfate glucuronosyltransferase, heparan sulfate synthesis enzyme, N-acetylglucosaminylproteoglycan beta-1,4-glucuronosyltransferase, RIB-1, RIB-2, sister of tout velu, sister of tout-velu, sotv, tout velu, tout-velu, ttv, UDP-glucuronate:oligosaccharide
ECTree
Source Tissue
Source Tissue on EC 2.4.1.225 - N-acetylglucosaminyl-proteoglycan 4-beta-glucuronosyltransferase
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peripheral chondrosarcoma
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Sv40 embryonic cell line
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enzyme EXT1
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EXT1, NDST1, and NDST2 differentially regulate heparan sulfate biosynthesis in human tooth germ
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loss of one copy of either the EXT1 or EXT2 gene product compromises the perichondrial chondrocytes ability to differentiate normally and to survive in a differentiated state in vitro
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articular chondrocyte
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skin-derived
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high level of EXT2 in EXT2-overexpressing mice
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FBJ, highly metastatic mouse osteosarcoma FBJ-LL cells and the poorly metastatic FBJ-S1 cells are produced from a FBJ virus-induced osteosarcoma
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FBJ, highly metastatic mouse osteosarcoma FBJ-LL cells and the poorly metastatic FBJ-S1 cells are produced from a FBJ virus-induced osteosarcoma
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additional information
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zebrafish ext2 gene is ubiquitously expressed during zebrafish development
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kidney extract is devoid of EXT2 in EXT2-overexpressing mice
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additional information
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T cells and B cells
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