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2.4.1.228: lactosylceramide 4-alpha-galactosyltransferase

This is an abbreviated version!
For detailed information about lactosylceramide 4-alpha-galactosyltransferase, go to the full flat file.

Word Map on EC 2.4.1.228

Reaction

UDP-alpha-D-galactose
+
beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide
=
UDP
 +
alpha-D-galactosyl-(1->4)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide

Synonyms

A4GalT, alpha 1-4 galactosyltransferase, alpha1,4-galactosyltransferase, alpha1,4Gal-T, blood group P1 synthase, Gal-beta1-4Glcbeta1-Cer alpha1,4-galactosyltransferase, galactosyltransferase, uridine diphosphogalactose-lactosylceramide, galactosyltransferase, uridine diphosphogalactose-lactosylceramide alpha1-4-, Gb3 galactosyltransferase, GB3 synthase, Gb3/CD77 synthase, Gb3Cer synthase, Gb3S, GCS, globotetraosyl ceramide synthase, globotriaosylceramide synthase, globotriaosylceramide/CD77 synthase, glucosylceramide synthase, histo-blood group Pk antigen synthase, histo-blood group Pk UDP-galactose, lactosylceramide 4-alpha-galactosyltransferase, lactosylceramide alpha1,4-galactosyltransferase, lactosylceramide alpha1,4galactosyltransferase, Pk synthase, UDP-galactose-lactosylceramide galactosyltransferase, UDP-galactose:beta-D-galactosyl-beta-1-R 4-alpha-D-galactosyltransferase, UDP-galactose:lactosylceramide alpha-galactosyltransferase, UDP-galactose:lactosylceramide alpha1-4-galactosyltransferase

ECTree

     2 Transferases
         2.4 Glycosyltransferases
             2.4.1 Hexosyltransferases
                2.4.1.228 lactosylceramide 4-alpha-galactosyltransferase

Cloned

Cloned on EC 2.4.1.228 - lactosylceramide 4-alpha-galactosyltransferase

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CLONED (Commentary)
ORGANISM
UNIPROT
LITERATURE
DNA sequence determination and analysis, functional expression in L-VTR1 cells, the recombinant cells produce high levels of P1 antigen in the cytoplasm with a small amount on the cell surface, expression as fusion protein with protein A secreted to the cell culture medium
-
expressed in insect Namalwa cells
expressed in mouse fibroblast L cells
-
expression analysis
-
expression of Gb3 synthase in transgenic TgG3S mice, and overexpression in COS-7 cells
-
gene A4GALT, a fragment of the A4GALT gene spanning nucleotides 130-1059 of the open reading frame with C or G at position 631 respectively, is cloned in-frame with c-myc and hexahistidine tags and recombinantly expressed in Spodoptera frugiperda Sf9 cells
the human Gb3S promoter is cloned and characterized
-