2.4.1.228: lactosylceramide 4-alpha-galactosyltransferase

This is an abbreviated version!
For detailed information about lactosylceramide 4-alpha-galactosyltransferase, go to the full flat file.

Word Map on EC 2.4.1.228

2.4.1.228

glycosphingolipids

sphingolipids

gangliosides

lysosomal

gaucher

sphingomyelin

glycolipids

multidrug

glccer

sphingomyelinase

sphingosine

p-glycoprotein

gm3

d-threo-1-phenyl-2-decanoylamino-3-morpholino-1-propanol

glucocerebrosidase

eliglustat

d-pdmp

niemann-pick

ceramide-induced

iminosugars

fabry

ceramidase

glucosylceramidase

shiga

nb-dnj

c6-ceramide

fumonisin

globo-series

dihydroceramide

1-phenyl-2-decanoylamino-3-morpholino-1-propanol

n-butyldeoxynojirimycin

gd1a

verotoxins

neuronopathic

medicine

Reaction

beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide

alpha-D-galactosyl-(1->4)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide

Synonyms

A4GalT, alpha 1-4 galactosyltransferase, alpha1,4-galactosyltransferase, alpha1,4Gal-T, blood group P1 synthase, Gal-beta1-4Glcbeta1-Cer alpha1,4-galactosyltransferase, galactosyltransferase, uridine diphosphogalactose-lactosylceramide, galactosyltransferase, uridine diphosphogalactose-lactosylceramide alpha1-4-, Gb3 galactosyltransferase, GB3 synthase, Gb3/CD77 synthase, Gb3Cer synthase, Gb3S, GCS, globotetraosyl ceramide synthase, globotriaosylceramide synthase, globotriaosylceramide/CD77 synthase, glucosylceramide synthase, histo-blood group Pk antigen synthase, histo-blood group Pk UDP-galactose, lactosylceramide 4-alpha-galactosyltransferase, lactosylceramide alpha1,4-galactosyltransferase, lactosylceramide alpha1,4galactosyltransferase, Pk synthase, UDP-galactose-lactosylceramide galactosyltransferase, UDP-galactose:beta-D-galactosyl-beta-1-R 4-alpha-D-galactosyltransferase, UDP-galactose:lactosylceramide alpha-galactosyltransferase, UDP-galactose:lactosylceramide alpha1-4-galactosyltransferase

ECTree

2 Transferases

2.4 Glycosyltransferases

2.4.1 Hexosyltransferases

2.4.1.228 lactosylceramide 4-alpha-galactosyltransferase

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Results	in table
4	Activating Compound
29	AA Sequence
2	Application
1	CAS Registry Number
8	Cloned(Commentary)
652	Disease/ Diagnostics
2	Expression
14	General Information
5	Inhibitors
7	KM Value [mM]
8	Localization
10	Metals/Ions
4	Molecular Weight [Da]
15	Natural Substrates/ Products (Substrates)
24	Organism
4	Pathway
4	pH Optimum
1	pH Range
3	Protein Variants
3	Purification (Commentary)
1	Reaction
3	Reaction Type
24	Reference
38	Source Tissue
8	Specific Activity [micromol/min/mg]
4	Storage Stability
32	Substrates and Products (Substrate)
2	Subunits
50	Synonyms
1	Systematic Name
6	Temperature Optimum [°C]

Substrates Products

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Substrates Products on EC 2.4.1.228 - lactosylceramide 4-alpha-galactosyltransferase

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UDP-Gal + Galbeta1,4Glc-PAA

UDP + ?

Homo sapiens

Q9NPC4

i.e. Lac-PAA, precursor to Pk

735618

UDP-Gal + Galbeta1,4GlcNAcbeta1,3Galbeta1,4Glc-PAA

UDP + ?

Homo sapiens

Q9NPC4

i.e. nLc4-PAA, precursor to P1

735618

UDP-Gal + GalNAcbeta1,3Galalpha1,4Galbeta1,4Glc-PAA

UDP + ?

Homo sapiens

Q9NPC4

i.e. Gbeta4-PAA, precursor to NOR1

735618

UDP-galactose + beta-D-galactosyl-(1,4)-D-glucosylceramide

UDP + alpha-D-galactosyl-(1,4)-beta-D-galactosyl-(1,4)-D-glucosylceramide

Homo sapiens

659273

UDP-galactose + beta-D-galactosyl-(1,4)-N-acetyl-beta-D-glucosaminyl-alpha-D-galactosyl-(1,4)-beta-D-glucosylceramide

UDP + alpha-D-galactosyl-(1,4)-beta-D-galactosyl-(1,4)-N-acetyl-beta-D-glucosaminyl-alpha-D-galactosyl-(1,4)-beta-D-glucosylceramide

Homo sapiens

P1 antigen synthesis

659273

UDP-galactose + beta-D-galactosyl-(1-4)-D-glucosyl-(1-1)-ceramide

UDP + alpha-D-galactosyl-(1-4)-beta-D-galactosyl-(1-4)-D-glucosyl-(1-1)-ceramide

2 entries

UDP-galactose + beta-D-galactosyl-(1-4)-D-glucosylceramide

UDP + alpha-D-galactosyl-(1-4)-beta-D-galactosyl-(1-4)-D-glucosylceramide

7 entries

UDP-galactose + galactosylceramide

Homo sapiens

488985

UDP-galactose + lactose

2 entries

UDP-galactose + lactosylceramide

UDP + globotriaosylceramide

8 entries

additional information

6 entries