2.4.1.229: [Skp1-protein]-hydroxyproline N-acetylglucosaminyltransferase

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For detailed information about [Skp1-protein]-hydroxyproline N-acetylglucosaminyltransferase, go to the full flat file.

Reaction

Synonyms

acetylglucosaminyltransferase, uridine diphosphoacetylglucosamine-glycoprotein serine/threonine, acetylglucosaminyltransferase, uridine diphosphoacetylglucose-protein Skp1 hydroxyproline, Dd-ppGnT1, GnT1, GnT51, hydroxyproline-capping enzyme, Skp1 alpha-GlcNAcT1, Skp1 alpha-GlcNAcT1-like enzyme, Skp1-HyPro GlcNAc-transferase, UDP-GlcNAc:hydroxyproline polypeptide GlcNAc-transferase, UDP-GlcNAc:Skp1-hydroxyproline GlcNAc-transferase, UDP-N-acetylglucosamine (GlcNAc):hydroxyproline polypeptide GlcNAc-transferase

ECTree

     2 Transferases

         2.4 Glycosyltransferases

             2.4.1 Hexosyltransferases

                2.4.1.229 [Skp1-protein]-hydroxyproline N-acetylglucosaminyltransferase

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Results	in table
10	Activating Compound
29	AA Sequence
2	CAS Registry Number
4	Cloned(Commentary)
4	General Information
1	General Stability
11	Inhibitors
3	KM Value [mM]
11	Localization
9	Metals/Ions
6	Molecular Weight [Da]
11	Natural Substrates/ Products (Substrates)
11	Organism
3	pH Optimum
5	Protein Variants
4	Purification (Commentary)
2	Reaction
1	Reaction Type
11	Reference
1	Specific Activity [micromol/min/mg]
29	Substrates and Products (Substrate)
5	Subunits
20	Synonyms
1	Systematic Name
1	Temperature Optimum [°C]
1	Temperature Stability [°C]

Systematic Name

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Systematic Name on EC 2.4.1.229 - [Skp1-protein]-hydroxyproline N-acetylglucosaminyltransferase

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SYSTEMATIC NAME

IUBMB Comments

UDP-N-acetyl-alpha-D-glucosamine:[Skp1-protein]-trans-4-hydroxy-L-proline N-acetyl-alpha-D-glucosaminyl-transferase

Skp1 is a cytoplasmic and nuclear protein required for the ubiquitination of cell cycle regulatory proteins and transcriptional factors. In Dictyostelium Skp1 is modified by the linear pentasaccharide Galalpha1-6Galalpha1-L-Fucalpha1-2Galbeta1-3GlcNAc, which is attached to a hydroxyproline residue at position 143. This enzyme catalyses the first step in the building up of the pentasaccharide by attaching an N-acetylglucosaminyl group to the hydroxyproline residue. It requires dithiothreitol and a divalent cation for activity.