2.4.1.231: alpha,alpha-trehalose phosphorylase (configuration-retaining)

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For detailed information about alpha,alpha-trehalose phosphorylase (configuration-retaining), go to the full flat file.

Reaction

Synonyms

PoTPase, ScTPase, TP2, TP3, trehalose phosphorylase

ECTree

     2 Transferases

         2.4 Glycosyltransferases

             2.4.1 Hexosyltransferases

                2.4.1.231 alpha,alpha-trehalose phosphorylase (configuration-retaining)

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Results	in table
4	Activating Compound
9	AA Sequence
1	Application
1	CAS Registry Number
2	Cloned(Commentary)
4	General Information
2	General Stability
40	Inhibitors
2	kcat/KM [mM/s]
21	Ki Value [mM]
44	KM Value [mM]
1	Metals/Ions
12	Molecular Weight [Da]
14	Natural Substrates/ Products (Substrates)
27	Organism
1	Pathway
15	pH Optimum
3	pH Range
2	pH Stability
2	pI Value
10	Protein Variants
10	Purification (Commentary)
7	Reaction
2	Reaction Type
25	Reference
24	Source Tissue
6	Specific Activity [micromol/min/mg]
1	Storage Stability
57	Substrates and Products (Substrate)
7	Subunits
14	Synonyms
1	Systematic Name
6	Temperature Optimum [°C]
9	Temperature Stability [°C]
32	Turnover Number [1/s]

Inhibitors

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Inhibitors on EC 2.4.1.231 - alpha,alpha-trehalose phosphorylase (configuration-retaining)

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INHIBITOR

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

IMAGE

1,5-anhydro-D-glucitol

Schizophyllum commune

-

-

644900

1-deoxynojirimycin

2 entries

2-amino-2-deoxy-D-glucose

Schizophyllum commune

-

competitive with glucose

644905

2-deoxy-2-fluoro-alpha-D-glucose 1-fluoride

Schizophyllum commune

-

inhibits reaction with alpha,alpha-trehalose

644899

2-deoxy-2-fluoro-glucose 1-phosphate

Schizophyllum commune

-

-

644899

ADP

Agaricus bisporus

-

34% inhibition at 10 mM

644907

alpha-D-galactose 1-phosphate

Schizophyllum commune

-

-

644899

alpha-D-glucose

Schizophyllum commune

-

-

644899

alpha-D-glucose 1-fluoride

Schizophyllum commune

-

competitive with respect to alpha,alpha-trehalose in the phosphorolysis direction

644899

alpha-D-glucose 1-phosphate

2 entries

alpha-D-glucuronic acid 1-phosphate

Schizophyllum commune

-

-

644899

alpha-D-mannose 1-phosphate

Schizophyllum commune

-

-

644899

alpha-D-xylose 1-phosphate

Schizophyllum commune

-

-

644899

ATP

Agaricus bisporus

-

inhibits trehalose degradation, but stimulates synthetic activity

644907

CoCl2

Agaricus bisporus

-

39% inhibition at 1 mM

644907

Cu2+

Grifola frondosa

-

complete inactivation at 1 mM

644906

CuSO4

Agaricus bisporus

-

37% inhibition at 1 mM

644907

D-galactose

Schizophyllum commune

-

-

644899

D-glucal

Schizophyllum commune

-

-

644900, 644905

D-glucono-delta-lactone

Schizophyllum commune

-

-

644905

D-glucose

Schizophyllum commune

-

-

644900

D-xylose

Schizophyllum commune

-

-

644899

isofagomine

Schizophyllum commune

-

-

644905

NaCl

Schizophyllum commune

-

competitive with respect to phosphate

644898

orthovanadate

Schizophyllum commune

-

competitive against phosphate and alpha-D-glucopyranosyl phosphate, inhibits forward and reverse reaction

644905

phosphate

3 entries

S-trehalose

Schizophyllum commune

-

-

644900

validamycin A

Agaricus bisporus

-

99% inhibition at 10 mM

644907

validoxylamine A

Schizophyllum commune

Q2HZZ3

-

671872

vanadate

4 entries

Zn2+

Grifola frondosa

-

inactivation at 1 mM

644906

1-deoxynojirimycin

Agaricus bisporus

-

88% inhibition at 10 mM

644907

1-deoxynojirimycin

Schizophyllum commune

-

-

644905

alpha-D-glucose 1-phosphate

Schizophyllum commune

-

-

644899, 644900

alpha-D-glucose 1-phosphate

Schizophyllum commune

Q2HZZ3

-

671872

phosphate

Agaricus bisporus

-

inhibits synthetic activity

644907

phosphate

Schizophyllum commune

Q2HZZ3

-

671872

phosphate

Schizophyllum commune

-

phosphate 50 mM causes total supression in wild-type but enhances mutant K512 activity

692323

vanadate

Pleurotus ostreatus

-

-

674984

vanadate

Schizophyllum commune

-

phosphate mimic, inhibits phosphorolysis of alpha-D-glucose 1-fluoride by forming a ternary complex

644899

vanadate

Schizophyllum commune

-

-

691645

vanadate

Schizophyllum commune

-

strong inhibitor for wildtype ScTPase and weak inhibitor for mutant K512A but no mutant R507A is not inhibited at all

692323