2.4.1.250: D-inositol-3-phosphate glycosyltransferase

This is an abbreviated version!
For detailed information about D-inositol-3-phosphate glycosyltransferase, go to the full flat file.

Reaction

Synonyms

CgMshA, MshA, MSMEG0924, mycothiol glycosyltransferases

ECTree

     2 Transferases

         2.4 Glycosyltransferases

             2.4.1 Hexosyltransferases

                2.4.1.250 D-inositol-3-phosphate glycosyltransferase

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Results	in table
7285	AA Sequence
2	Cloned(Commentary)
1	Crystallization (Commentary)
8	General Information
1	Inhibitors
4	KM Value [mM]
6	Natural Substrates/ Products (Substrates)
12	Organism
1	Pathway
1	Purification (Commentary)
3	Reaction
11	Reference
1	Storage Stability
17	Substrates and Products (Substrate)
9	Synonyms
1	Systematic Name

Substrates Products

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Substrates Products on EC 2.4.1.250 - D-inositol-3-phosphate glycosyltransferase

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SUBSTRATE

PRODUCT                       

REACTION DIAGRAM

ORGANISM

UNIPROT

COMMENTARY
(Substrate)

LITERATURE
(Substrate)

COMMENTARY
(Product)

LITERATURE
(Product)

Reversibility
r=reversible
ir=irreversible
?=not specified

1D-myo-inositol 3-phosphate + UDP-N-acetyl-alpha-D-glucosamine

1D-myo-inositol 2-acetamido-2-deoxy-alpha-D-glucopyranoside 3-phosphate + UDP

2 entries

UDP-N-acetyl-D-glucosamine + 1D-myo-inositol 1-phosphate

?

2 entries

UDP-N-acetyl-D-glucosamine + 1D-myo-inositol 3-phosphate

1-O-(2-acetamido-2-deoxy-alpha-D-glucopyranosyl)-1D-myo-inositol 3-phosphate + UDP

11 entries

UDP-N-acetyl-D-glucosamine + myo-inositol 2-phosphate

?

2 entries

1D-myo-inositol 3-phosphate + UDP-N-acetyl-alpha-D-glucosamine

1D-myo-inositol 2-acetamido-2-deoxy-alpha-D-glucopyranoside 3-phosphate + UDP

Corynebacterium glutamicum

Q8NTA6

the reaction proceeds via a front-side SNi-like concerted reaction mechanism

759657

-

-

?

1D-myo-inositol 3-phosphate + UDP-N-acetyl-alpha-D-glucosamine

1D-myo-inositol 2-acetamido-2-deoxy-alpha-D-glucopyranoside 3-phosphate + UDP

Corynebacterium glutamicum ATCC 13032

Q8NTA6

the reaction proceeds via a front-side SNi-like concerted reaction mechanism

759657

-

-

?

UDP-N-acetyl-D-glucosamine + 1D-myo-inositol 1-phosphate

?

Mycolicibacterium smegmatis

A0QQY9

at 10% of the activity with 1D-myo-inositol 3-phosphate

698734

-

-

?

UDP-N-acetyl-D-glucosamine + 1D-myo-inositol 1-phosphate

?

Mycolicibacterium smegmatis mc(2)155 / ATCC 700084

A0QQY9

at 10% of the activity with 1D-myo-inositol 3-phosphate

698734

-

-

?

UDP-N-acetyl-D-glucosamine + 1D-myo-inositol 3-phosphate

1-O-(2-acetamido-2-deoxy-alpha-D-glucopyranosyl)-1D-myo-inositol 3-phosphate + UDP

Corynebacterium glutamicum

-

1D-myo-inositol 3-phosphate i.e. 1L-myo-inositol 1-phosphate, committed step of mycothiol biosynthesis

698755

-

-

?

UDP-N-acetyl-D-glucosamine + 1D-myo-inositol 3-phosphate

1-O-(2-acetamido-2-deoxy-alpha-D-glucopyranosyl)-1D-myo-inositol 3-phosphate + UDP

Corynebacterium glutamicum

-

1D-myo-inositol 3-phosphate i.e. 1L-myo-inositol 1-phosphate. Molecular models of the ternary complex suggest a mechanism in which the beta-phosphate of the substrate, UDP-N-acetylglucosamine, promotes the nucleophilic attack of the 3-hydroxyl group of 1D-myo-inositol 3-phosphate while at the same time promoting the cleavage of the sugar nucleotide bond

698755

-

-

?

UDP-N-acetyl-D-glucosamine + 1D-myo-inositol 3-phosphate

1-O-(2-acetamido-2-deoxy-alpha-D-glucopyranosyl)-1D-myo-inositol 3-phosphate + UDP

Mycobacterium tuberculosis

-

1D-myo-inositol 3-phosphate i.e. 1L-myo-inositol 1-phosphate, the mshA gene is essential for the growth of Mycobacterium tuberculosis

697971

-

-

?

UDP-N-acetyl-D-glucosamine + 1D-myo-inositol 3-phosphate

1-O-(2-acetamido-2-deoxy-alpha-D-glucopyranosyl)-1D-myo-inositol 3-phosphate + UDP

Mycobacterium tuberculosis

-

1D-myo-inositol 3-phosphate i.e. 1L-myo-inositol 1-phosphate

697971

-

-

?

UDP-N-acetyl-D-glucosamine + 1D-myo-inositol 3-phosphate

1-O-(2-acetamido-2-deoxy-alpha-D-glucopyranosyl)-1D-myo-inositol 3-phosphate + UDP

Mycobacterium tuberculosis Erdman

-

1D-myo-inositol 3-phosphate i.e. 1L-myo-inositol 1-phosphate, the mshA gene is essential for the growth of Mycobacterium tuberculosis

697971

-

-

?

UDP-N-acetyl-D-glucosamine + 1D-myo-inositol 3-phosphate

1-O-(2-acetamido-2-deoxy-alpha-D-glucopyranosyl)-1D-myo-inositol 3-phosphate + UDP

Mycobacterium tuberculosis Erdman

-

1D-myo-inositol 3-phosphate i.e. 1L-myo-inositol 1-phosphate

697971

-

-

?

UDP-N-acetyl-D-glucosamine + 1D-myo-inositol 3-phosphate

1-O-(2-acetamido-2-deoxy-alpha-D-glucopyranosyl)-1D-myo-inositol 3-phosphate + UDP

Mycolicibacterium smegmatis

-

1D-myo-inositol 3-phosphate i.e. 1L-myo-inositol 1-phosphate, mycothiol biosynthesis

698567

-

-

?

UDP-N-acetyl-D-glucosamine + 1D-myo-inositol 3-phosphate

1-O-(2-acetamido-2-deoxy-alpha-D-glucopyranosyl)-1D-myo-inositol 3-phosphate + UDP

Mycolicibacterium smegmatis

A0QQY9

1D-myo-inositol 3-phosphate i.e. 1L-myo-inositol 1-phosphate, mycothiol biosynthesis

698734

-

-

?

UDP-N-acetyl-D-glucosamine + 1D-myo-inositol 3-phosphate

1-O-(2-acetamido-2-deoxy-alpha-D-glucopyranosyl)-1D-myo-inositol 3-phosphate + UDP

Mycolicibacterium smegmatis

A0QQY9

1D-myo-inositol 3-phosphate i.e. 1L-myo-inositol 1-phosphate. Little activity is obtained with myo-inositol, 1D-myo-inositol 1-phosphate, or myo-inositol 2-phosphate as the N-acetylglucosamine acceptor. 1D-myo-inositol 1-phosphate is neither a good substrate nor an inhibitor of MshA. Therfore the commercially available 1DL-myo-inositol 1-phosphate can be used as substrate for MshA assays without complications

698734

-

-

?

UDP-N-acetyl-D-glucosamine + 1D-myo-inositol 3-phosphate

1-O-(2-acetamido-2-deoxy-alpha-D-glucopyranosyl)-1D-myo-inositol 3-phosphate + UDP

Mycolicibacterium smegmatis mc(2)155 / ATCC 700084

A0QQY9

1D-myo-inositol 3-phosphate i.e. 1L-myo-inositol 1-phosphate, mycothiol biosynthesis

698734

-

-

?

UDP-N-acetyl-D-glucosamine + 1D-myo-inositol 3-phosphate

1-O-(2-acetamido-2-deoxy-alpha-D-glucopyranosyl)-1D-myo-inositol 3-phosphate + UDP

Mycolicibacterium smegmatis mc(2)155 / ATCC 700084

A0QQY9

1D-myo-inositol 3-phosphate i.e. 1L-myo-inositol 1-phosphate. Little activity is obtained with myo-inositol, 1D-myo-inositol 1-phosphate, or myo-inositol 2-phosphate as the N-acetylglucosamine acceptor. 1D-myo-inositol 1-phosphate is neither a good substrate nor an inhibitor of MshA. Therfore the commercially available 1DL-myo-inositol 1-phosphate can be used as substrate for MshA assays without complications

698734

-

-

?

UDP-N-acetyl-D-glucosamine + myo-inositol 2-phosphate

?

Mycolicibacterium smegmatis

A0QQY9

at 10% of the activity with 1D-myo-inositol 3-phosphate

698734

-

-

?

UDP-N-acetyl-D-glucosamine + myo-inositol 2-phosphate

?

Mycolicibacterium smegmatis mc(2)155 / ATCC 700084

A0QQY9

at 10% of the activity with 1D-myo-inositol 3-phosphate

698734

-

-

?