2.4.1.253: baicalein 7-O-glucuronosyltransferase

This is an abbreviated version!
For detailed information about baicalein 7-O-glucuronosyltransferase, go to the full flat file.

Reaction

Synonyms

UBGAT, UDP-glucuronate baicalein 7-O-glucuronosyltransferase, UDP-glucuronate:baicalein 7-O-glucuronosyltransferase

ECTree

     2 Transferases

         2.4 Glycosyltransferases

             2.4.1 Hexosyltransferases

                2.4.1.253 baicalein 7-O-glucuronosyltransferase

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Results	in table
1	AA Sequence
4	Expression
9	Inhibitors
1	kcat/KM [mM/s]
4	KM Value [mM]
1	Metals/Ions
2	Molecular Weight [Da]
5	Natural Substrates/ Products (Substrates)
7	Organism
2	Pathway
1	pH Optimum
1	pI Value
1	Purification (Commentary)
1	Reaction
6	Reference
5	Source Tissue
1	Specific Activity [micromol/min/mg]
1	Storage Stability
14	Substrates and Products (Substrate)
2	Subunits
9	Synonyms
1	Systematic Name
1	Temperature Optimum [°C]
1	Temperature Stability [°C]

Substrates Products

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Substrates Products on EC 2.4.1.253 - baicalein 7-O-glucuronosyltransferase

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SUBSTRATE

PRODUCT                       

REACTION DIAGRAM

ORGANISM

UNIPROT

COMMENTARY
(Substrate)

LITERATURE
(Substrate)

COMMENTARY
(Product)

LITERATURE
(Product)

Reversibility
r=reversible
ir=irreversible
?=not specified

UDP-D-glucuronate + 4',5,6,7-tetrahydroxyflavone

UDP + 4',5,6,7-tetrahydroxyflavone 7-O-beta-D-glucuronate

2 entries

UDP-D-glucuronate + 5,6,7-trihydroxyflavone

UDP + 5,6,7-trihydroxyflavone-7-O-beta-D-glucuronate

2 entries

UDP-D-glucuronate + 5,7-dihydroxy-8-methoxyflavone

UDP + 5,7-dihydroxy-8-methoxyflavone-7-O-beta-D-glucuronate

2 entries

UDP-D-glucuronate + baicalein

UDP + baicalin

2 entries

UDP-glucuronate + baicalein

UDP + baicalin

Scutellaria baicalensis

-

-

706115, 712081

-

-

?

additional information

?

-

2 entries

UDP-D-glucuronate + 4',5,6,7-tetrahydroxyflavone

UDP + 4',5,6,7-tetrahydroxyflavone 7-O-beta-D-glucuronate

Scutellaria baicalensis

-

i.e. 5,6,7-trihydroxy-2-(4-hydroxyphenyl)chromen-4-one, i.e. scutellarein. The enzyme is specific to UDP-glucuronic acid as a sugar donor and flavones with substitution ortho- to the 7-OH group such as baicalein (6-OH), scutellarein (6-OH) and wogonin (8-OMe)

706115

i.e. scutellarein 7-O-glucuronide

-

?

UDP-D-glucuronate + 4',5,6,7-tetrahydroxyflavone

UDP + 4',5,6,7-tetrahydroxyflavone 7-O-beta-D-glucuronate

Scutellaria baicalensis Georgi

-

i.e. 5,6,7-trihydroxy-2-(4-hydroxyphenyl)chromen-4-one, i.e. scutellarein. The enzyme is specific to UDP-glucuronic acid as a sugar donor and flavones with substitution ortho- to the 7-OH group such as baicalein (6-OH), scutellarein (6-OH) and wogonin (8-OMe)

706115

i.e. scutellarein 7-O-glucuronide

-

?

UDP-D-glucuronate + 5,6,7-trihydroxyflavone

UDP + 5,6,7-trihydroxyflavone-7-O-beta-D-glucuronate

Scutellaria baicalensis

-

i.e. 5,6,7-trihydroxy-2-phenyl-4H-chromen-4-one, i.e. baicalein. The enzyme is specific to UDP-glucuronic acid as a sugar donor and flavones with substitution ortho- to the 7-OH group such as baicalein (6-OH), scutellarein (6-OH) and wogonin (8-OMe)

706115

i.e. 5,6-dihydroxy-4-oxo-2-phenyl-4H-chromen-7-yl beta-D-glucopyranosiduronic acid, i.e. baicalein 7-O-glucuronide, i.e. 5,6-dihydroxy-4-oxo-2-phenyl-4H-chromen-7-yl beta-D-glucopyranosiduronic acid, i.e. baicalein 7-O-glucuronide. Identification and quantitation of the enzyme reaction products are carried out by reversed phase-HPLC

-

?

UDP-D-glucuronate + 5,6,7-trihydroxyflavone

UDP + 5,6,7-trihydroxyflavone-7-O-beta-D-glucuronate

Scutellaria baicalensis Georgi

-

i.e. 5,6,7-trihydroxy-2-phenyl-4H-chromen-4-one, i.e. baicalein. The enzyme is specific to UDP-glucuronic acid as a sugar donor and flavones with substitution ortho- to the 7-OH group such as baicalein (6-OH), scutellarein (6-OH) and wogonin (8-OMe)

706115

i.e. 5,6-dihydroxy-4-oxo-2-phenyl-4H-chromen-7-yl beta-D-glucopyranosiduronic acid, i.e. baicalein 7-O-glucuronide, i.e. 5,6-dihydroxy-4-oxo-2-phenyl-4H-chromen-7-yl beta-D-glucopyranosiduronic acid, i.e. baicalein 7-O-glucuronide. Identification and quantitation of the enzyme reaction products are carried out by reversed phase-HPLC

-

?

UDP-D-glucuronate + 5,7-dihydroxy-8-methoxyflavone

UDP + 5,7-dihydroxy-8-methoxyflavone-7-O-beta-D-glucuronate

Scutellaria baicalensis

-

i.e. 5,7-dihydroxy-8-methoxy-2-phenylchromen-4-one, i.e. wogonin. The enzyme is specific to UDP-glucuronic acid as a sugar donor and flavones with substitution ortho- to the 7-OH group such as baicalein (6-OH), scutellarein (6-OH) and wogonin (8-OMe)

706115

i.e wogonin 7-O-glucuronide

-

?

UDP-D-glucuronate + 5,7-dihydroxy-8-methoxyflavone

UDP + 5,7-dihydroxy-8-methoxyflavone-7-O-beta-D-glucuronate

Scutellaria baicalensis Georgi

-

i.e. 5,7-dihydroxy-8-methoxy-2-phenylchromen-4-one, i.e. wogonin. The enzyme is specific to UDP-glucuronic acid as a sugar donor and flavones with substitution ortho- to the 7-OH group such as baicalein (6-OH), scutellarein (6-OH) and wogonin (8-OMe)

706115

i.e wogonin 7-O-glucuronide

-

?

UDP-D-glucuronate + baicalein

UDP + baicalin

Scutellaria baicalensis

Q76MR7

-

759908

-

-

?

UDP-D-glucuronate + baicalein

UDP + baicalin

Scutellaria baicalensis Georgi

Q76MR7

-

759908

-

-

?

additional information

?

-

Scutellaria baicalensis

-

flavonoids lacking a substitution at the position ortho- to the 7-OH (chrysin, apigenin, luteolin, quercetin, formononetin and daidzein) do not serve as substrates

706115

-

-

?

additional information

?

-

Scutellaria baicalensis Georgi

-

flavonoids lacking a substitution at the position ortho- to the 7-OH (chrysin, apigenin, luteolin, quercetin, formononetin and daidzein) do not serve as substrates

706115

-

-

?