2.4.1.257: GDP-Man:Man2GlcNAc2-PP-dolichol alpha-1,6-mannosyltransferase

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For detailed information about GDP-Man:Man2GlcNAc2-PP-dolichol alpha-1,6-mannosyltransferase, go to the full flat file.

Reaction

alpha-D-Man-(1->3)-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol

alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol

Synonyms

Alg2, Alg2 mannosyltransferase, Alg2 MTase, More, MTase, scAlg2

ECTree

2 Transferases

2.4 Glycosyltransferases

2.4.1 Hexosyltransferases

2.4.1.257 GDP-Man:Man2GlcNAc2-PP-dolichol alpha-1,6-mannosyltransferase

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Results	in table
3485	AA Sequence
1	Application
3	Cloned(Commentary)
5	General Information
9	Localization
1	Metals/Ions
5	Natural Substrates/ Products (Substrates)
7	Organism
6	Pathway
4	pH Optimum
1	Posttranslational Modification
31	Protein Variants
3	Purification (Commentary)
1	Reaction
7	Reference
12	Substrates and Products (Substrate)
12	Synonyms
1	Systematic Name
4	Temperature Optimum [°C]

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Application on EC 2.4.1.257 - GDP-Man:Man2GlcNAc2-PP-dolichol alpha-1,6-mannosyltransferase

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synthesis

Saccharomyces cerevisiae

engineering of a synthetic pathway in Escherichia coli for the production of eukaryotic trimannosyl chitobiose glycans and the transfer of these glycans to specific asparagine residues in target proteins. Glycan biosynthesis is enabled by four eukaryotic glycosyltransferases, including the yeast uridine diphosphate-N-acetylglucosamine transferases Alg13 and Alg14 and the mannosyltransferases Alg1 and Alg2. By including the bacterial oligosaccharyltransferase PglB from Campylobacter jejuni, glycans are successfully transferred to eukaryotic proteins

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