2.4.1.270: mannosylglucosyl-3-phosphoglycerate synthase
This is an abbreviated version!
For detailed information about mannosylglucosyl-3-phosphoglycerate synthase, go to the full flat file.
Reaction
Synonyms
MggA, RB5546
ECTree
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Substrates Products
Substrates Products on EC 2.4.1.270 - mannosylglucosyl-3-phosphoglycerate synthase
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REACTION DIAGRAM
ADP-mannose + 2-O-(alpha-D-glucopyranosyl)-3-phospho-D-glycerate
ADP + 2-(2-O-(alpha-D-mannopyranosyl)-alpha-D-glucopyranosyl)-3-phospho-D-glycerate
GDP-mannose + 2-O-(alpha-D-glucopyranosyl)-3-phospho-D-glycerate
GDP + 2-(2-O-(alpha-D-mannopyranosyl)-alpha-D-glucopyranosyl)-3-phospho-D-glycerate
UDP-mannose + 2-O-(alpha-D-glucopyranosyl)-3-phospho-D-glycerate
UDP + 2-(2-O-(alpha-D-mannopyranosyl)-alpha-D-glucopyranosyl)-3-phospho-D-glycerate
ADP + 2-(2-O-(alpha-D-mannopyranosyl)-alpha-D-glucopyranosyl)-3-phospho-D-glycerate
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ADP-mannose + 2-O-(alpha-D-glucopyranosyl)-3-phospho-D-glycerate
ADP + 2-(2-O-(alpha-D-mannopyranosyl)-alpha-D-glucopyranosyl)-3-phospho-D-glycerate
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GDP + 2-(2-O-(alpha-D-mannopyranosyl)-alpha-D-glucopyranosyl)-3-phospho-D-glycerate
the enzyme is involved in the phosphorylating pathway for synthesis of the solute mannosylglucosylglycerate. In Petrotoga mobilis two alternative pathways for the synthesis of the rare solute mannosylglucosylglycerate are proposed. The first one is a a phosphorylating pathway (with a phosphorylated intermediate) from 3-phosphoglycerate and UDP-glucose to the final solute. The second nonphosphorylating pathway (no phosphorylated intermediates) could represent an alternative route for the synthesis of mannosylglucosylglycerate in Petrotoga mobilis that could lead to the direct conversion of glucosylglycerate and GDP-mannose to mannosylglucosylglycerate. Pathway multiplicity likely reflects a crucial role for mannosylglucosylglycerate in the physiology of Petrotoga mobilis mobilis during stress adaptation
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GDP-mannose + 2-O-(alpha-D-glucopyranosyl)-3-phospho-D-glycerate
GDP + 2-(2-O-(alpha-D-mannopyranosyl)-alpha-D-glucopyranosyl)-3-phospho-D-glycerate
no activity with UDP-mannose or mannose-1-phosphate as sugar donors, and 3-phospho-D-glycerate, 2-alpha-D-glucosylglycerate, and glucosyl-3-phosphoglycerate as the sugar acceptors
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GDP-mannose + 2-O-(alpha-D-glucopyranosyl)-3-phospho-D-glycerate
GDP + 2-(2-O-(alpha-D-mannopyranosyl)-alpha-D-glucopyranosyl)-3-phospho-D-glycerate
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GDP-mannose + 2-O-(alpha-D-glucopyranosyl)-3-phospho-D-glycerate
GDP + 2-(2-O-(alpha-D-mannopyranosyl)-alpha-D-glucopyranosyl)-3-phospho-D-glycerate
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UDP + 2-(2-O-(alpha-D-mannopyranosyl)-alpha-D-glucopyranosyl)-3-phospho-D-glycerate
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UDP-mannose + 2-O-(alpha-D-glucopyranosyl)-3-phospho-D-glycerate
UDP + 2-(2-O-(alpha-D-mannopyranosyl)-alpha-D-glucopyranosyl)-3-phospho-D-glycerate
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enzyme is non-specific for the mannosyl-donor, using GDP-mannose, UDP-mannose and ADP-mannose as substrates with decreasing affinity. From the tested substrates only 2-(O-alpha-D-glucopyranosyl)-3-phospho-D-glycerate is used as mannosyl-acceptor. The enzyme is a configuration retaining sugar transferase
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additional information
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enzyme is non-specific for the mannosyl-donor, using GDP-mannose, UDP-mannose and ADP-mannose as substrates with decreasing affinity. From the tested substrates only 2-(O-alpha-D-glucopyranosyl)-3-phospho-D-glycerate is used as mannosyl-acceptor. The enzyme is a configuration retaining sugar transferase
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