2.4.1.275: neolactotriaosylceramide beta-1,4-galactosyltransferase

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For detailed information about neolactotriaosylceramide beta-1,4-galactosyltransferase, go to the full flat file.

Word Map on EC 2.4.1.275

2.4.1.275

glycosphingolipids

laccer

d-pdmp

sphingolipids

glycolipids

ganglioside

d-threo-1-phenyl-2-decanoylamino-3-morpholino-1-propanol

glct-1

galt-2

glucosyltransferase

hbecs

gm3

hemolytic-uremic

Reaction

N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide

beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide

Synonyms

UDP-Gal:glucosylceramide beta1->4galactosyltransferase, beta-1,4-GalT IV, beta4Gal-T4, GalT-4, lactosylceramide synthase, lactotriaosylceramide:galactosyltransferase, LcOse3Cer:Gal-Tr, UDP-Gal:GLcNAcbeta1-3Galbeta1-4Glc-Cer beta1-4galactosyltransferase, UDP-Gal:Lc3 beta1-4galactosyltransferase, UDP-galactose:beta-N-acetylglucosamine beta1,4-galactosyltransferase, UDPGal:betaGlcNAc beta1,4Gal-transferase, uridine diphosphate-galactose:glucosyl ceramide, beta 1-4 galactosyltransferase

ECTree

2 Transferases

2.4 Glycosyltransferases

2.4.1 Hexosyltransferases

2.4.1.275 neolactotriaosylceramide beta-1,4-galactosyltransferase

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Results	in table
1	Activating Compound
16	AA Sequence
2	Cloned(Commentary)
2	General Information
2	General Stability
2	Inhibitors
4	KM Value [mM]
1	Localization
4	Metals/Ions
1	Natural Substrates/ Products (Substrates)
4	Organism
3	Pathway
1	pH Optimum
1	Purification (Commentary)
1	Reaction
4	Reference
13	Source Tissue
1	Specific Activity [micromol/min/mg]
18	Substrates and Products (Substrate)
13	Synonyms
1	Systematic Name
1	Temperature Optimum [°C]

Source Tissue

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Source Tissue on EC 2.4.1.275 - neolactotriaosylceramide beta-1,4-galactosyltransferase

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central nervous system

Homo sapiens

O60513

715438

cerebellar Purkinje cell

Rattus norvegicus

the specific activities of Gal-Tr is nearly normal or slightly elevated in all the three Purkinje cell abnormality mutants

638234

cerebellum

Rattus norvegicus

specific activities of Gal-Tr in the granule cell layer and white matter is approximately 66% of that in the molecular layer. Gal-Tr in the homogenate of cerebellum declines by approximately 35-45% from postnatal day 3 to 14. Gal-Tr activity in the granule cells does not change with age. The relative Gal-Tr activity in granule cells to homogenate is between 0.13 and 0.23

mineral oil induced