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2.4.1.278: 3-alpha-mycarosylerythronolide B desosaminyl transferase

This is an abbreviated version!
For detailed information about 3-alpha-mycarosylerythronolide B desosaminyl transferase, go to the full flat file.

Word Map on EC 2.4.1.278

Reaction

dTDP-D-desosamine
+
3-alpha-L-mycarosylerythronolide B
=
dTDP
+
erythromycin D

Synonyms

DesVII, EryCIII, glycosyltransferase EryCIII

ECTree

     2 Transferases
         2.4 Glycosyltransferases
             2.4.1 Hexosyltransferases
                2.4.1.278 3-alpha-mycarosylerythronolide B desosaminyl transferase

Cofactor

Cofactor on EC 2.4.1.278 - 3-alpha-mycarosylerythronolide B desosaminyl transferase

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COFACTOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
AKnT protein
-
the noncognate glycosyltransferase activator protein AknT, stably activates EryCIII. Addition of purified AknT to inactive EryCIII restores the activity of EryCIII in vitro
-
EryCII protein
-
glycosyltransferase activator protein EryCII activates EryCIII. EryCIII treated with EryCII is catalytically active, effecting transfer of desosamine to 3-alpha-mycarosylerythronolide. The untreated EryCIII sample shows no activity
-