2.4.1.278: 3-alpha-mycarosylerythronolide B desosaminyl transferase

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For detailed information about 3-alpha-mycarosylerythronolide B desosaminyl transferase, go to the full flat file.

Word Map on EC 2.4.1.278

2.4.1.278

erythromycin

saccharopolyspora

macrolide

erythraea

polyketide

glycosyltransferases

deoxysugars

d-desosamine

erythromycin-producing

macrolactone

peucetius

6-deoxyerythronolide

medicine

spinosyns

interspecies

14-membered

antibioticus

auxiliary

aglycone

Reaction

Synonyms

DesVII, EryCIII, glycosyltransferase EryCIII

ECTree

2 Transferases

2.4 Glycosyltransferases

2.4.1 Hexosyltransferases

2.4.1.278 3-alpha-mycarosylerythronolide B desosaminyl transferase

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Results	in table
97	AA Sequence
2	Application
2	Cloned(Commentary)
2	Cofactor
2	General Information
1	kcat/KM [mM/s]
1	KM Value [mM]
1	Natural Substrates/ Products (Substrates)
3	Organism
6	Pathway
1	pH Optimum
2	Purification (Commentary)
1	Reaction
3	Reference
1	Storage Stability
5	Substrates and Products (Substrate)
4	Synonyms
1	Systematic Name
1	Temperature Optimum [°C]
3	Turnover Number [1/s]

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Reference on EC 2.4.1.278 - 3-alpha-mycarosylerythronolide B desosaminyl transferase

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715245

Lee, H.Y.; Chung, H.S.; Hang, C.; Khosla, C.; Walsh, C.T.; Kahne, D.; Walker, S.

Reconstitution and characterization of a new desosaminyl transferase, EryCIII, from the erythromycin biosynthetic pathway

J. Am. Chem. Soc.

126

9924-9925

2004

Saccharopolyspora erythraea

15303858

715246

Yuan, Y.; Chung, H.S.; Leimkuhler, C.; Walsh, C.T.; Kahne, D.; Walker, S.

In vitro reconstitution of EryCIII activity for the preparation of unnatural macrolides

J. Am. Chem. Soc.

127

14128-14129

2005

Saccharopolyspora erythraea

16218575

735516

Wu, H.; Li, W.; Xin, C.; Zhang, C.; Wang, Y.; Ren, S.; Ren, M.; Zhao, W.; Yuan, L.; Xu, Z.; Yuan, H.; Geng, M.; Zhang, L.; Weaver, D.T.; Zhang, B.

In vivo investigation to the macrolide-glycosylating enzyme pair DesVII/DesVIII in Saccharopolyspora erythraea

Appl. Microbiol. Biotechnol.

100

2257-2266

2016

Streptomyces venezuelae (Q9ZGH7)

26552796