2.4.1.298: anthocyanidin 3-O-glucoside 5-O-glucosyltransferase
This is an abbreviated version!
For detailed information about anthocyanidin 3-O-glucoside 5-O-glucosyltransferase, go to the full flat file.
Reaction
Synonyms
5-GT, 5GT, 5GT3, anthocyanin 5-O-glucosyltransferase, Gt5GT7, LOC100265923, UDP-glucose:anthocyanin 5-O-glucosyltransferase, UPI00023B2329
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General Information
General Information on EC 2.4.1.298 - anthocyanidin 3-O-glucoside 5-O-glucosyltransferase
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evolution
malfunction
physiological function
Gt5GT7 belongs to the 5GT subfamily of the glycosyltransferase superfamily of enzymes. The Gt5GT7 contains a 44 amino acid consensus signature sequence, the so-called plant secondary product glycosyltransferase (PSPG) motif, which is highly conserved among plant glycosyltransferases
evolution
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Gt5GT7 belongs to the 5GT subfamily of the glycosyltransferase superfamily of enzymes. The Gt5GT7 contains a 44 amino acid consensus signature sequence, the so-called plant secondary product glycosyltransferase (PSPG) motif, which is highly conserved among plant glycosyltransferases
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sequence analysis of the enzyme from cultivar Regent reveals five amino acid substitutions and a truncation at the C-terminus causing the inactivation of the enzyme
malfunction
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sequence analysis of the enzyme from cultivar Regent reveals five amino acid substitutions and a truncation at the C-terminus causing the inactivation of the enzyme
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5GT is a key enzyme in the biosynthesis of bis-glucosidic anthocyanins in Vitis amurensis grape berries
physiological function
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Vitis vinifera ssp. vinifera and its wild progenitor Vitis vinifera ssp. sylvestris share many loss-of-function 5GT alleles and extensive divergence of the 5GT alleles is evident. Eighteen 5GT alleles with apparent loss-of-function mutations, including seven premature stop codon mutations and six frameshift indel mutations, are discovered in Vitis vinifera, but not in the other Vitis species. A total of 36 5GT alleles without apparent loss-of-function mutations (W-type) are identified. These W-type alleles are predominantlypresent in wild Vitis species, although a few of them are also found in some Vitis vinifera accessions