2.4.1.315: diglucosyl diacylglycerol synthase (1,6-linking)
This is an abbreviated version!
For detailed information about diglucosyl diacylglycerol synthase (1,6-linking), go to the full flat file.
Word Map on EC 2.4.1.315
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2.4.1.315
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glycolipids
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glycoglycerolipids
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genitalium
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mycoplasma
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udpglc
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synthases
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glycosyltransferases
- 2.4.1.315
- glycolipids
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glycoglycerolipids
- genitalium
- mycoplasma
- udpglc
- synthases
- glycosyltransferases
Reaction
Synonyms
beta-diglucosyldiacylglycerol synthase, DGlcDAG synthase, MG517, MGlcDAG (1->6) glucosyltransferase, monoglucosyl diacylglycerol (1->6) glucosyltransferase, processive diacylglycerol beta-glucosyltransferase, UDP-glucose:diacylglycerol glucosyltransferase, UGT106B1, UgtP, ypfP
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2.4.1.315 diglucosyl diacylglycerol synthase (1,6-linking)Advanced search results
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results (Substrates Products
Substrates Products on EC 2.4.1.315 - diglucosyl diacylglycerol synthase (1,6-linking)
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SUBSTRATE 
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
GDP-alpha-D-glucose + 1,2-diacyl-3-O-(alpha-D-glucopyranosyl)-sn-glycerol
1,2-diacyl-3-O-[alpha-D-glucopyranosyl-(1->6)-O-alpha-D-glucopyranosyl]-sn-glycerol + UDP
UDP-alpha-D-galactose + 1,2-diacyl-3-O-(alpha-D-glucopyranosyl)-sn-glycerol
1,2-diacyl-3-O-[alpha-D-galactopyranosyl-(1->6)-O-alpha-D-glucopyranosyl]-sn-glycerol + UDP
9% of the specific activity with 1,2-diacyl-sn-glycerol
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-
?
UDP-alpha-D-glucose + 1,2-diacyl-3-O-(alpha-D-glucopyranosyl)-sn-glycerol
1,2-diacyl-3-O-[alpha-D-glucopyranosyl-(1->6)-O-alpha-D-glucopyranosyl]-sn-glycerol + UDP
UDP-alpha-D-glucose + 1,2-diacyl-3-O-[alpha-D-glucopyranosyl-(1->6)-alpha-D-glucopyranosyl-(1->6)-O-alpha-D-glucopyranosyl]-sn-glycerol
1,2-diacyl-3-O-[alpha-D-glucopyranosyl-(1->6)-alpha-D-glucopyranosyl-(1->6)-alpha-D-glucopyranosyl-(1->6)-O-alpha-D-glucopyranosyl]-sn-glycerol + UDP
UDP-alpha-D-glucose + 1,2-diacyl-3-O-[alpha-D-glucopyranosyl-(1->6)-O-alpha-D-glucopyranosyl]-sn-glycerol
1,2-diacyl-3-O-[alpha-D-glucopyranosyl-(1->6)-alpha-D-glucopyranosyl-(1->6)-O-alpha-D-glucopyranosyl]-sn-glycerol + UDP
UDP-alpha-D-glucose + 1,2-diacyl-sn-glycerol
1,2-diacyl-3-O-(alpha-D-glucopyranosyl)-sn-glycerol + UDP
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-
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?
UDP-alpha-D-glucose + glycero-3-phospho-(1'-sn-glycerol)
alpha-D-glucopyranosyl-glycero-3-phospho-(1'-sn-glycerol) + UDP
GDP-alpha-D-glucose + 1,2-diacyl-3-O-(alpha-D-glucopyranosyl)-sn-glycerol
1,2-diacyl-3-O-[alpha-D-glucopyranosyl-(1->6)-O-alpha-D-glucopyranosyl]-sn-glycerol + UDP
GDP-glucose shows poor activity
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-
?
GDP-alpha-D-glucose + 1,2-diacyl-3-O-(alpha-D-glucopyranosyl)-sn-glycerol
1,2-diacyl-3-O-[alpha-D-glucopyranosyl-(1->6)-O-alpha-D-glucopyranosyl]-sn-glycerol + UDP
GDP-glucose shows poor activity
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-
?
UDP-alpha-D-glucose + 1,2-diacyl-3-O-(alpha-D-glucopyranosyl)-sn-glycerol
1,2-diacyl-3-O-[alpha-D-glucopyranosyl-(1->6)-O-alpha-D-glucopyranosyl]-sn-glycerol + UDP
can only use UDP-glucose as sugar donor
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-
?
UDP-alpha-D-glucose + 1,2-diacyl-3-O-(alpha-D-glucopyranosyl)-sn-glycerol
1,2-diacyl-3-O-[alpha-D-glucopyranosyl-(1->6)-O-alpha-D-glucopyranosyl]-sn-glycerol + UDP
can only use UDP-glucose as sugar donor. Can form tetraglucosyl diacylglycerol in vitro
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-
?
UDP-alpha-D-glucose + 1,2-diacyl-3-O-(alpha-D-glucopyranosyl)-sn-glycerol
1,2-diacyl-3-O-[alpha-D-glucopyranosyl-(1->6)-O-alpha-D-glucopyranosyl]-sn-glycerol + UDP
can only use UDP-glucose as sugar donor
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-
?
UDP-alpha-D-glucose + 1,2-diacyl-3-O-(alpha-D-glucopyranosyl)-sn-glycerol
1,2-diacyl-3-O-[alpha-D-glucopyranosyl-(1->6)-O-alpha-D-glucopyranosyl]-sn-glycerol + UDP
can only use UDP-glucose as sugar donor. Can form tetraglucosyl diacylglycerol in vitro
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-
?
UDP-alpha-D-glucose + 1,2-diacyl-3-O-(alpha-D-glucopyranosyl)-sn-glycerol
1,2-diacyl-3-O-[alpha-D-glucopyranosyl-(1->6)-O-alpha-D-glucopyranosyl]-sn-glycerol + UDP
2.2% of the specific activity with 1,2-diacyl-sn-glycerol
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-
?
UDP-alpha-D-glucose + 1,2-diacyl-3-O-(alpha-D-glucopyranosyl)-sn-glycerol
1,2-diacyl-3-O-[alpha-D-glucopyranosyl-(1->6)-O-alpha-D-glucopyranosyl]-sn-glycerol + UDP
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-
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?
UDP-alpha-D-glucose + 1,2-diacyl-3-O-(alpha-D-glucopyranosyl)-sn-glycerol
1,2-diacyl-3-O-[alpha-D-glucopyranosyl-(1->6)-O-alpha-D-glucopyranosyl]-sn-glycerol + UDP
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-
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?
UDP-alpha-D-glucose + 1,2-diacyl-3-O-[alpha-D-glucopyranosyl-(1->6)-alpha-D-glucopyranosyl-(1->6)-O-alpha-D-glucopyranosyl]-sn-glycerol
1,2-diacyl-3-O-[alpha-D-glucopyranosyl-(1->6)-alpha-D-glucopyranosyl-(1->6)-alpha-D-glucopyranosyl-(1->6)-O-alpha-D-glucopyranosyl]-sn-glycerol + UDP
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-
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?
UDP-alpha-D-glucose + 1,2-diacyl-3-O-[alpha-D-glucopyranosyl-(1->6)-alpha-D-glucopyranosyl-(1->6)-O-alpha-D-glucopyranosyl]-sn-glycerol
1,2-diacyl-3-O-[alpha-D-glucopyranosyl-(1->6)-alpha-D-glucopyranosyl-(1->6)-alpha-D-glucopyranosyl-(1->6)-O-alpha-D-glucopyranosyl]-sn-glycerol + UDP
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-
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?
UDP-alpha-D-glucose + 1,2-diacyl-3-O-[alpha-D-glucopyranosyl-(1->6)-O-alpha-D-glucopyranosyl]-sn-glycerol
1,2-diacyl-3-O-[alpha-D-glucopyranosyl-(1->6)-alpha-D-glucopyranosyl-(1->6)-O-alpha-D-glucopyranosyl]-sn-glycerol + UDP
can only use UDP-glucose as sugar donor
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-
?
UDP-alpha-D-glucose + 1,2-diacyl-3-O-[alpha-D-glucopyranosyl-(1->6)-O-alpha-D-glucopyranosyl]-sn-glycerol
1,2-diacyl-3-O-[alpha-D-glucopyranosyl-(1->6)-alpha-D-glucopyranosyl-(1->6)-O-alpha-D-glucopyranosyl]-sn-glycerol + UDP
can only use UDP-glucose as sugar donor. Can form tetraglucosyl diacylglycerol in vitro
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-
?
UDP-alpha-D-glucose + 1,2-diacyl-3-O-[alpha-D-glucopyranosyl-(1->6)-O-alpha-D-glucopyranosyl]-sn-glycerol
1,2-diacyl-3-O-[alpha-D-glucopyranosyl-(1->6)-alpha-D-glucopyranosyl-(1->6)-O-alpha-D-glucopyranosyl]-sn-glycerol + UDP
can only use UDP-glucose as sugar donor
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-
?
UDP-alpha-D-glucose + 1,2-diacyl-3-O-[alpha-D-glucopyranosyl-(1->6)-O-alpha-D-glucopyranosyl]-sn-glycerol
1,2-diacyl-3-O-[alpha-D-glucopyranosyl-(1->6)-alpha-D-glucopyranosyl-(1->6)-O-alpha-D-glucopyranosyl]-sn-glycerol + UDP
can only use UDP-glucose as sugar donor. Can form tetraglucosyl diacylglycerol in vitro
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-
?
UDP-alpha-D-glucose + 1,2-diacyl-3-O-[alpha-D-glucopyranosyl-(1->6)-O-alpha-D-glucopyranosyl]-sn-glycerol
1,2-diacyl-3-O-[alpha-D-glucopyranosyl-(1->6)-alpha-D-glucopyranosyl-(1->6)-O-alpha-D-glucopyranosyl]-sn-glycerol + UDP
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main product
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?
UDP-alpha-D-glucose + glycero-3-phospho-(1'-sn-glycerol)
alpha-D-glucopyranosyl-glycero-3-phospho-(1'-sn-glycerol) + UDP
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?
UDP-alpha-D-glucose + glycero-3-phospho-(1'-sn-glycerol)
alpha-D-glucopyranosyl-glycero-3-phospho-(1'-sn-glycerol) + UDP
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?
additional information
?
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enzyme transfers glucosyl and galactosyl residues from UDP-Glc and UDP-Gal to dioleoylglycerol acceptor to form the corresponding beta-glycosyl-dioleoylglycerol, which then acts as acceptor to give beta-diglycosyl-dioleoylglycerol products. Enzyme sequentially adds glycosyl residues with beta-1,6 connectivity, the first glycosyltransferase activity to dioleoylglycerol being about 1 order of magnitude higher than the second to monoglucosyldioleoylglycerol
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?
additional information
?
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enzyme transfers glucosyl and galactosyl residues from UDP-Glc and UDP-Gal to dioleoylglycerol acceptor to form the corresponding beta-glycosyl-dioleoylglycerol, which then acts as acceptor to give beta-diglycosyl-dioleoylglycerol products. Enzyme sequentially adds glycosyl residues with beta-1,6 connectivity, the first glycosyltransferase activity to dioleoylglycerol being about 1 order of magnitude higher than the second to monoglucosyldioleoylglycerol
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?
additional information
?
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1,2-diacyl-3-O-[alpha-D-glucopyranosyl-(1->6)-alpha-D-glucopyranosyl-(1-6)-O-alpha-D-glucopyranosyl]-sn-glycerol, i.e. diglucosyl diacylglycerol, is not further converted to triglucosyl diacylglycerol. Not accepted as substrates are UDP-galactose, UDP-mannose, GDP-mannose, UDP-xylose, and UDP-Nacetylglucosamine. Cholesterol, cholesterolglucoside and the fluorescent substrate 6-[[(N-7-nitrobenz-2-oxa-1,3-diazol-4-yl)amino]caproyl]sphingosine, i.e.NBD-ceramide, can alos serve as acceptors that are converted into more polar products
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additional information
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1,2-diacyl-3-O-[alpha-D-glucopyranosyl-(1->6)-alpha-D-glucopyranosyl-(1-6)-O-alpha-D-glucopyranosyl]-sn-glycerol, i.e. diglucosyl diacylglycerol, is not further converted to triglucosyl diacylglycerol. Not accepted as substrates are UDP-galactose, UDP-mannose, GDP-mannose, UDP-xylose, and UDP-Nacetylglucosamine. Cholesterol, cholesterolglucoside and the fluorescent substrate 6-[[(N-7-nitrobenz-2-oxa-1,3-diazol-4-yl)amino]caproyl]sphingosine, i.e.NBD-ceramide, can alos serve as acceptors that are converted into more polar products
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?
additional information
?
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1,2-diacyl-3-O-[alpha-D-glucopyranosyl-(1->6)-alpha-D-glucopyranosyl-(1-6)-O-alpha-D-glucopyranosyl]-sn-glycerol, i.e. diglucosyl diacylglycerol, is not further converted to triglucosyl diacylglycerol. Not accepted as substrates are UDP-galactose, UDP-mannose, GDP-mannose, UDP-xylose, and UDP-Nacetylglucosamine. Cholesterol, cholesterolglucoside and the fluorescent substrate 6-[[(N-7-nitrobenz-2-oxa-1,3-diazol-4-yl)amino]caproyl]sphingosine, i.e.NBD-ceramide, can alos serve as acceptors that are converted into more polar products
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