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2.4.1.331: 8-demethyltetracenomycin C L-rhamnosyltransferase

This is an abbreviated version!
For detailed information about 8-demethyltetracenomycin C L-rhamnosyltransferase, go to the full flat file.

Word Map on EC 2.4.1.331

Reaction

dTDP-beta-L-rhamnose
+
8-demethyltetracenomycin C
=
dTDP
+
8-demethyl-8-alpha-L-rhamnosyltetracenomycin C

Synonyms

elloramycin glycosyltransferase, ElmGT

ECTree

     2 Transferases
         2.4 Glycosyltransferases
             2.4.1 Hexosyltransferases
                2.4.1.331 8-demethyltetracenomycin C L-rhamnosyltransferase

Engineering

Engineering on EC 2.4.1.331 - 8-demethyltetracenomycin C L-rhamnosyltransferase

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PROTEIN VARIANTS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
L309A
mutation in residue of the alpha/beta/alpha motif, results in 4fold increase in efficiency of L-olivose transfer to 8-demethyltetracenomycin C
L309H
mutation in residue of the alpha/beta/alpha motif, results in decreases in the efficiency of deoxysugar transfer to 8-demethyltetracenomycin C
L309I
mutation in residue of the alpha/beta/alpha motif, results in 2fold increase in efficiency of L-rhamnose transfer to 8-demethyltetracenomycin C
L309M
mutation in residue of the alpha/beta/alpha motif, results in decreases in the efficiency of deoxysugar transfer to 8-demethyltetracenomycin C
L309Q
mutation in residue of the alpha/beta/alpha motif, results in decreases in the efficiency of deoxysugar transfer to 8-demethyltetracenomycin C
L309V
mutation in residue of the alpha/beta/alpha motif, results in 6fold increase in efficiency of L-olivose transfer to 8-demethyltetracenomycin C
L309Y
mutation in residue of the alpha/beta/alpha motif, results in 2fold increase in efficiency of L-olivose transfer to 8-demethyltetracenomycin C
N312Q
mutation in residue of the alpha/beta/alpha motif, results in 2fold increase in efficiency of L-olivose transfer to 8-demethyltetracenomycin C
N312S
mutation in residue of the alpha/beta/alpha motif, results in 2fold increase in efficiency of L-olivose transfer to 8-demethyltetracenomycin C
N312T
mutation in residue of the alpha/beta/alpha motif, results in 3fold increase in efficiency of L-olivose transfer to 8-demethyltetracenomycin C
L309A
-
mutation in residue of the alpha/beta/alpha motif, results in 4fold increase in efficiency of L-olivose transfer to 8-demethyltetracenomycin C
-
L309Q
-
mutation in residue of the alpha/beta/alpha motif, results in decreases in the efficiency of deoxysugar transfer to 8-demethyltetracenomycin C
-
L309V
-
mutation in residue of the alpha/beta/alpha motif, results in 6fold increase in efficiency of L-olivose transfer to 8-demethyltetracenomycin C
-
L309Y
-
mutation in residue of the alpha/beta/alpha motif, results in 2fold increase in efficiency of L-olivose transfer to 8-demethyltetracenomycin C
-
N312Q
-
mutation in residue of the alpha/beta/alpha motif, results in 2fold increase in efficiency of L-olivose transfer to 8-demethyltetracenomycin C
-