2.4.1.336: monoglucosyldiacylglycerol synthase
This is an abbreviated version!
For detailed information about monoglucosyldiacylglycerol synthase, go to the full flat file.
Word Map on EC 2.4.1.336
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2.4.1.336
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synechocystis
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cyanobacterial
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galactolipids
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unsaturated
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monotopic
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monogalactosyldiacylglycerol
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thylakoid
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glycosyltransferase
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phosphatidylglycerol
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digalactosyldiacylglycerol
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laidlawii
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acholeplasma
- 2.4.1.336
- synechocystis
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cyanobacterial
- galactolipids
- unsaturated
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monotopic
- monogalactosyldiacylglycerol
- thylakoid
- glycosyltransferase
- phosphatidylglycerol
- digalactosyldiacylglycerol
- laidlawii
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acholeplasma
Reaction
Synonyms
all3944, beta-monoglucosyldiacylglycerol synthase, EC 2.4.1.157, MGD1, MgdA, MGS, monoglucosyldiacylglycerol synthase, Sll1377, UDP-glucose:1,2-diacylglycerol 3-beta-D-glucosyltransferase
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General Information on EC 2.4.1.336 - monoglucosyldiacylglycerol synthase
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GENERAL INFORMATION 
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
metabolism
the enzyme is involved in the lipid synthesis in Synechocystis, pathway overview
physiological function
physiological function
functional expression of MGD1 in Synechocystis sp. to obtain a viable monoglucosyldiacylglycerol-deficient mutant of the cyanobacterium. Monoglucosyldiacylglycerol is not essential for its growth and photosynthesis under a set of normal growth conditions when monogalactosyldiacylglycerol is adequately supplied by the Arabidopsis monogalactosyldiacylglycerol synthase. The mutant has healthy thylakoidmembranes and normal pigment content. The membrane lipid composition of the mutant is similar to wild-type except for lack of monoglucosyldiacylglycerol and a slight increase in the level of phosphatidylglycerol at both normal and low temperatures.The ratio of unsaturated fatty acids in monogalactosyldiacylglycerol and digalactosyldiacylglycerol is reduced in the mutant compared with wild-type. The growth of the mutant is indistinguishable with that of wild-type at normal growth temperature, it is markedly retarded at low temperature
physiological function
enzyme binds to the membrane in a fairly upright manner, mainly by residues in the N-terminal domain, and in a way that induces local enrichment of anionic lipids and a local curvature deformation. Several MGS variants resulting from substitution of residues in the membrane anchoring segment are still able to generate vesicles when heterologously expressed in Escherichia coli, regardless of enzymatic activity
physiological function
membrane protein monoglucosyldiacylglycerol synthase MGS is responsible for the creation of intracellular membranes when overexpressed in Escherichia coli. During 22 h of MGS induction, the lipid/protein ratio increases by 38% in MGS-expressing cells compared to control cells. Unsaturation levels remain constant for MGS cells (about 62%) but significantly decrease in control cells (from 61% to 36%). Cyclopropanated fatty acid content is lower in MGS producing cells while control cells have an increased cyclopropanation activity. Among all lipids, phosphatidylethanolamine is the most affected species in terms of cyclopropanation
physiological function
role of enzyme MGS protein on stress regulation and cyclopropane fatty acid synthase activity. The fatty acid composition changes in enzyme MGS-overexpressing cells, overview
physiological function
synthesis of monogalactosyldiacylglycerol and digalactosyldiacylglycerol, the major membrane lipids in cyanobacteria, begins with production of the intermediate precursor monoglucosyldiacylglycerol, by monoglucosyldiacylglycerol synthase
