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2.4.1.37: fucosylgalactoside 3-alpha-galactosyltransferase

This is an abbreviated version!
For detailed information about fucosylgalactoside 3-alpha-galactosyltransferase, go to the full flat file.

Word Map on EC 2.4.1.37

Reaction

UDP-alpha-D-galactose
+
alpha-L-fucosyl-(1->2)-D-galactosyl-R
=
UDP
 +
alpha-D-galactosyl-(1->3)-[alpha-L-fucosyl(1->2)]-D-galactosyl-R

Synonyms

ABO(H) blood group B alpha-(1->3)-galactosyltransferase, ABO(H) blood group B alpha-1,3-galactosyltransferase, ABO(H) blood group B glycosyltransferase, ABO(H) blood-group glycosyltransferase B, alpha(1-3)galactosyltransferase, alpha-(1,3)-galactosyltransferase, alpha-(1-3)-galactosyltransferase, alpha-(1->3)-galactosyltransferase, alphaGal-T1, B glycosyltransferase, B transferase, blood group alpha-(1-3)-galactosyltransferase, blood group B alpha-(1,3)-galactosyltransferase, blood group B galactosyltransferase, blood group B glycosyltransferase, blood group B glycosyltransferase GTB, blood group B-glycosyltransferase, blood-group substance B-dependent galactosyltransferase, cis-AB-transferase, glycoprotein-fucosylgalactoside alpha-galactosyltransferase, glycosyltransferases B, GTB, histo-blood group ABO system transferase, histo-blood group B enzyme, histo-blood group B transferase, histo-blood substance B-dependent galactosyltransferase, More, UDP-galactose:fucoside alpha1,3-galactosyltransferase, UDP-galactose:O-alpha-L-fucosyl(1-2)D-galactose alpha-D-galactosyltransferase, UDPgalactose:glycoprotein-alpha-L-fucosyl-(1,2)-D-galactose 3-alpha-D-galactosyltransferase, [blood group substance] alpha-galactosyltransferase

ECTree

     2 Transferases
         2.4 Glycosyltransferases
             2.4.1 Hexosyltransferases
                2.4.1.37 fucosylgalactoside 3-alpha-galactosyltransferase

Inhibitors

Inhibitors on EC 2.4.1.37 - fucosylgalactoside 3-alpha-galactosyltransferase

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INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
1-(1-benzothiophen-3-yl)methanamine
-
-
1-(2-chloro-6-fluorobenzyl)piperazine
-
-
1-(3-methoxyphenyl)piperazine
-
-
1-(3-phenyl-1,2,4-thiadiazol-5-yl)-1,4-diazepane
-
-
1-(3-phenyl-1,2,4-thiadiazol-5-yl)piperazine
1-methyl-1H-benzotriazole-5-carboxylic acid
-
-
1-[3-(naphthalen-1-yl)-1,2,4-thiadiazol-5-yl]piperazine
-
2,3-dimethylquinoxaline-6-carboxylic acid
-
-
2-amino-2-deoxy-D-galactosamine
-
-
7-aminothieno[2,3-b]pyrazine-6-carboxylic acid
-
-
9-(5-O-alpha-D-galactopyranosyl)-D-arabinityl-1,3,7-trihydropurine-2,6,8-trione
-
extremely specific inhibitor
9-(D-1-deoxy-arabinit-1-yl)-1,3,7-trihydropurine-2,6,8-trione
-
-
9-D-ribityl-1,3,7-trihydropurine-2,6,8-trione
-
-
alpha-L-Fuc-(1,2)-beta-D-3-amino-3-deoxy-Gal-O-octyl
-
-
alpha-L-fucosyl-(1-2)-beta-D-(3-amino)-galactosyl-O-R
complex mode inhibitor, binding structure, Met226 is involved by interacting with the C3-position group
alpha-L-fucosyl-(1-2)-beta-D-(3-deoxy)-galactosyl-O-R
competitive inhibitor, binding structure, Met226 is involved by interacting with the C3-position group
alpha-L-Fucp-(1,2)-beta-D-(3-amino-3-deoxy)-Galp-O-(CH2)7-CH3
-
-
beta-D-(3-amino-3-desoxy)-Galp-O-(CH2)7-CH3
-
-
EDTA
-
complete inhibition
Fucalpha(1,2)Galbeta1-benzyl
-
competitive, 37% and 61% inhibition at 1 mM and 4 mM, respectively
N-methyl-1-[3-(pyridin-3-yl)phenyl]methanamine
-
-
N-methyl-1-[3-(pyridin-4-yl)phenyl]methanamine
-
-
octyl 3'-amino-3'-deoxy-alpha-L-fucopyranosyl-(1-2)-beta-D-galactopyranoside
octyl 3'-deoxy-alpha-L-fucopyranosyl-(1-2)-beta-D-galactopyranoside
-
-
octyl alpha-L-fucopyranosyl-(1-2)-beta-D-gulopyranoside
UDP
-
competitive with respect to UDP-galactose
UDP-N-acetylgalactosamine
-
weak, competitive with respect to UDP-galactose
additional information
-