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2.4.1.38: beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase

This is an abbreviated version!
For detailed information about beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase, go to the full flat file.

Word Map on EC 2.4.1.38

Reaction

UDP-alpha-D-galactose
+
N-acetyl-beta-D-glucosaminylglycopeptide
=
UDP
 +
beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminylglycopeptide

Synonyms

(alpha4Gal-T1), 4betaGalT, acetyllactosamine synthetase, alpha-1,4-galactosyltransferase I, B4GALT1, beta 1, 4-GalT-I, beta 1,4-galactosyltransferase 1, beta 1,4-GalT-I, beta 1,4GalT V, beta(1,4)-galactosyltransferase, beta(1,4)-GalT, beta(1,4)-GT, beta-1,4 galactosyltransferase I, beta-1,4 galactosyltransferase V, beta-1,4-galactosyltransferase, beta-1,4-galactosyltransferase 1, beta-1,4-galactosyltransferase I, beta-1,4-galactosyltransferase IV, beta-1,4-galactosyltransferase-I, beta-1,4-GalT, beta-1,4-GalT I, beta-1,4-GalT V, beta-1,4-GalT-I, beta-1,4-GalT5, beta-1,4-GalT6, beta-1,4-GalT7, beta-1,4-GT-IV, beta-N-acetyl-beta1-4-galactosyltransferase, beta-N-acetylglucosaminide beta1-4-galactosyltransferase, beta1,4-Gal-transferase T1, beta1,4-galactosyltransferase, beta1,4-galactosyltransferase 1, beta1,4-galactosyltransferase 7, beta1,4-galactosyltransferase I, beta1,4-galactosyltransferase II, beta1,4-galactosyltransferase V, beta1,4-galactosyltransferase-1, beta1,4-galactosyltransferase-I, beta1,4-galactosyltransferase1, beta1,4-GalT1, beta1,4-GalT7, beta1,4-GT, beta1,4-GT 1, beta1,4GalT II, beta1,4GT1, beta1-4-galactosyltransferase, beta1-4GalT, beta1-4GalT1, beta4 Gal-transferase, beta4-GalT-I, beta4-GalT-II, beta4-GalT-III, beta4-GalT-IV, beta4-GalT-V, beta4Gal-T1, beta4GalT, beta4GalT-II, beta4GalT1, beta4GalT7, betaGalT, betaGalT-1, betaGALT1, betaGT, EC 2.4.1.98, Gal-T, Gal-T1, galactosyltransferase 7, galactosyltransferase, uridine diphosphogalactose-acetylglucosamine, GalNAcT2, GALT, GalT I, GalT V, GalT1, GalTase, GalTI, glycoprotein 4-beta-galactosyl-transferase, glycoprotein beta-galactosyltransferase, HP0826, lactosamine synthase, lactosamine synthetase, lactose synthetase A protein, LgtB, LgtB-A, LgtB-B, LgtH, More, N-acetylglucosamine beta1,4 galactosyltransferase, N-acetyllactosamine synthetase, NAL synthetase, thyroid galactosyltransferase, thyroid glycoprotein beta-galactosyltransferase, UDP-beta-1,4-galactosyltransferase, UDP-Gal:betaGlcNAc beta-1,4-galactosyltransferase, polypeptide 1, UDP-Gal:N-acetylglucosamine beta1-4-galactosyltransferase, UDP-galactose N-acetylglucosamine beta-4-galactosyltransferase, UDP-galactose-acetylglucosamine galactosyltransferase, UDP-galactose-N-acetylglucosamine beta-1,4-galactosyltransferase, UDP-galactose-N-acetylglucosamine galactosyltransferase, UDP-galactose:N-acetylglucosaminide beta1-4-galactosyltransferase, UDP-N-acetylgalactosamine:polypeptide N-acetylgalactosaminyltransferase 2, UDPgalactose-glycoprotein galactosyltransferase, UDPgalactose-N-acetylglucosamine beta-D-galactosyltransferase, UDPgalactose:N-acetyl-beta-D-glucosaminylglycopeptide beta-1,4-galactosyltransferase, UDPgalactose:N-acetylglucosaminyl(beta1-4)galactosyltransferase, uridine diphosphogalactose-acetylglucosamine galactosyltransferase, uridine diphosphogalactose-glycoprotein galactosyltransferase

ECTree

     2 Transferases
         2.4 Glycosyltransferases
             2.4.1 Hexosyltransferases
                2.4.1.38 beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase

Cloned

Cloned on EC 2.4.1.38 - beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase

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CLONED (Commentary)
ORGANISM
UNIPROT
LITERATURE
cloning and sequencing of cDNA
-
cloning and sequencing of the full-length cDNA
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cloning of the 5'-region flanking the transcription start point of the GalT I gene
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comparison of sequences of enzyme from placenta and HeLa cells
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DNA and amino acid sequence determination and analysis, expresion analysis, stable overexpression of HA-tagged GalT V in astrocytes C8-D30 and glioma cell lines U87 and U251, expression of mutant enzymes
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DNA and amino acid sequence determination and anaylsis, sequence comparisons
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ectopic expression in SMMC-7721 hepatocarcinoma cells overexpressing the CDK11(p58) kinase
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enzymatically active soluble N-deglycosylated enzyme form
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enzyme fused to protein A is expressed as a soluble form in COS-7 cells
expressed in Escherichia coli BL21(DE3) cells
expressed in Escherichia coli DH5alpha cells
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expressed in HeLa cells and as a fusion protein with maltose-binding protein in Escherichia coli BL21(DE3) cells
-
expressed in Nicotiana tabacum
expressed in NIH-3T3 cells
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expressed in Sf9 insect cells
expression as GFP-tagged enzyme in HeLa cells
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expression in Cos-1 cells
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expression in Drosophila melanogaster S2 cells
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expression in Escherichia coli
expression in Sf9 cells. Sfbeta4GalT cell, unlike the parental Sf9 cells, can terminally beta1,4-galactosylate gp64 during baculovirus infection
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expression of full-length HP0826 in Escherichia coli
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expression of mutant cDNA from a patient with the congenital disorder of glycosylation type IId leads to the synthesis of a truncated, inactive polypeptide, which is localized to the endoplasmic reticulum
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expression of mutants W312C/P401C and W312C/P401C/M340H enzymes in Escherichia coli, the wild-type enzyme forms inclusion bodies after expression in Escherichia coli, overview
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expression of short and long enzyme form in CHO-cells
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expression of wild-type and mutant enzymes in Escherichia coli
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expression of wild-type and mutant M340H enzymes in Escherichia coli
expression under the control of the T7 promoter in Escherichia coli BL21
functional expression in suspension cultured tobacco BY2 GT6 cells via Agrobacterium tumefaciens strain LBA4404
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HeLa cells expressing the murine enzyme on their surface spread more rapidly on laminin substrates than do control cells
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histidine-tagged 46000 Da protein produced in Escherichia coli
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isolation and characterization of the genomic locus
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isolation of a cDNA clone that encodes a major portion of galactosyltransferase
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molecular cloning and nucleotide sequencing
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overexpression in human hepatocarcinoma SMMC-7721 cells
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recombinant enzyme is N-glycosylated
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stem region fused to the catalytic domain, expression in Escherichia coli