2.4.1.38: beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase
This is an abbreviated version!
For detailed information about beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase, go to the full flat file.
Word Map on EC 2.4.1.38
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2.4.1.38
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galts
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galactosylate
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synthesis
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alpha-lactalbumin
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p34cdc2-related
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beta4galts
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drug development
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pharmacology
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medicine
- 2.4.1.38
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galts
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galactosylate
- synthesis
- alpha-lactalbumin
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p34cdc2-related
- beta4galts
- drug development
- pharmacology
- medicine
Reaction
Synonyms
(alpha4Gal-T1), 4betaGalT, acetyllactosamine synthetase, alpha-1,4-galactosyltransferase I, B4GALT1, beta 1, 4-GalT-I, beta 1,4-galactosyltransferase 1, beta 1,4-GalT-I, beta 1,4GalT V, beta(1,4)-galactosyltransferase, beta(1,4)-GalT, beta(1,4)-GT, beta-1,4 galactosyltransferase I, beta-1,4 galactosyltransferase V, beta-1,4-galactosyltransferase, beta-1,4-galactosyltransferase 1, beta-1,4-galactosyltransferase I, beta-1,4-galactosyltransferase IV, beta-1,4-galactosyltransferase-I, beta-1,4-GalT, beta-1,4-GalT I, beta-1,4-GalT V, beta-1,4-GalT-I, beta-1,4-GalT5, beta-1,4-GalT6, beta-1,4-GalT7, beta-1,4-GT-IV, beta-N-acetyl-beta1-4-galactosyltransferase, beta-N-acetylglucosaminide beta1-4-galactosyltransferase, beta1,4-Gal-transferase T1, beta1,4-galactosyltransferase, beta1,4-galactosyltransferase 1, beta1,4-galactosyltransferase 7, beta1,4-galactosyltransferase I, beta1,4-galactosyltransferase II, beta1,4-galactosyltransferase V, beta1,4-galactosyltransferase-1, beta1,4-galactosyltransferase-I, beta1,4-galactosyltransferase1, beta1,4-GalT1, beta1,4-GalT7, beta1,4-GT, beta1,4-GT 1, beta1,4GalT II, beta1,4GT1, beta1-4-galactosyltransferase, beta1-4GalT, beta1-4GalT1, beta4 Gal-transferase, beta4-GalT-I, beta4-GalT-II, beta4-GalT-III, beta4-GalT-IV, beta4-GalT-V, beta4Gal-T1, beta4GalT, beta4GalT-II, beta4GalT1, beta4GalT7, betaGalT, betaGalT-1, betaGALT1, betaGT, EC 2.4.1.98, Gal-T, Gal-T1, galactosyltransferase 7, galactosyltransferase, uridine diphosphogalactose-acetylglucosamine, GalNAcT2, GALT, GalT I, GalT V, GalT1, GalTase, GalTI, glycoprotein 4-beta-galactosyl-transferase, glycoprotein beta-galactosyltransferase, HP0826, lactosamine synthase, lactosamine synthetase, lactose synthetase A protein, LgtB, LgtB-A, LgtB-B, LgtH, More, N-acetylglucosamine beta1,4 galactosyltransferase, N-acetyllactosamine synthetase, NAL synthetase, thyroid galactosyltransferase, thyroid glycoprotein beta-galactosyltransferase, UDP-beta-1,4-galactosyltransferase, UDP-Gal:betaGlcNAc beta-1,4-galactosyltransferase, polypeptide 1, UDP-Gal:N-acetylglucosamine beta1-4-galactosyltransferase, UDP-galactose N-acetylglucosamine beta-4-galactosyltransferase, UDP-galactose-acetylglucosamine galactosyltransferase, UDP-galactose-N-acetylglucosamine beta-1,4-galactosyltransferase, UDP-galactose-N-acetylglucosamine galactosyltransferase, UDP-galactose:N-acetylglucosaminide beta1-4-galactosyltransferase, UDP-N-acetylgalactosamine:polypeptide N-acetylgalactosaminyltransferase 2, UDPgalactose-glycoprotein galactosyltransferase, UDPgalactose-N-acetylglucosamine beta-D-galactosyltransferase, UDPgalactose:N-acetyl-beta-D-glucosaminylglycopeptide beta-1,4-galactosyltransferase, UDPgalactose:N-acetylglucosaminyl(beta1-4)galactosyltransferase, uridine diphosphogalactose-acetylglucosamine galactosyltransferase, uridine diphosphogalactose-glycoprotein galactosyltransferase
ECTree
2.4.1.38 beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferaseAdvanced search results
results (
results (Crystallization
Crystallization on EC 2.4.1.38 - beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase
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CRYSTALLIZATION (Commentary) 
ORGANISM
UNIPROT
LITERATURE
catalytic domain of R228K-Gal-T1 and mouse recombinant alpha-lactalbumin are cocrystallized in the presence of UDP-galactose and MnCl2. Crystals are grown at room temperature by the hanging drop method. Crystal structure of R228K-Gal-T1 complexed with alpha-lactalbumin, UDP-galactose, and Mn2+, determined at 1.9 Å resolution shows that the Asp318 side chain exhibits a minor alternate conformation, compared to that in the wild type
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crystal structures of the beta4galactosyltransferase catalytic domain and its complex with uridine diphosphogalactose
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purified recombinant pentenary complex of bovine M344H-Gal-T1 mutant-Mn2+-UDP-GalNAc-Glc-alpha-lactalbumin, hanging-drop vapor diffusion method, using 20 mg/ml of beta-M344H-Gal-T1 and 10 mg/ml of mouse alpha-lactalbumin in the presence of 10 mM each ofUDP-Gal and CaCl2, with the precipitant containing 100 mM NaCl, 100 mM Mes-NaOH buffer, pH 6.0, and 12.5% PEG 4000, the crystals of the complex cannot be obtained in the absence of CaCl2, X-ray diffraction structure determination and analysis at 1.9-2.0 A resolution
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recombinant enzyme, crystal structure of lactose synthase reveals a large conformational change in its catalytic component, the beta1,4-galactosyltransferase-I
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mutant enzyme M340H/C338T in complex with Glc-NAcbeta1-3Galbeta-O-naphthalenemethanol, hanging drop vapor diffusion method, using MES-NaOH buffer (pH 6.0), 1.5 M ammonium sulfate, and 3% dioxane
purified recombinant M340H-Gal-T1 mutant in the open conformation as apo-enzyme, and its Mn2+ and Mn2+-UDP-Gal-bound complexes, hanging-drop vapor diffusion method using a protein solution at 10 mg/ml concentration with a precipitant containing sodium citratebuffer, pH 5.5, and 10% w/v PEG-4000, the crystals of the Mn2+ complex are grown in the droplet containing 10 mM MnCl2, while the crystals containing UDP-Gal and Mn2+ are grown in the presence of 17 mM each of MnCl2 and UDPGal, X-ray diffraction structure determination and analysis at 1.7-2.0 A resolution
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purified wild-type and M340H mutant enzymes in complex with pentasaccharide GlcNAcbeta1,2-Manalpha1,6 (GlcNAcbeta1,2-Manalpha1,3) and trisaccharide GlcNAcbeta1,4-GlcNAcbeta1,4-GlcNAc substrates, X-ray diffraction structure determination and analysis at 1.9-2.0 A resolution
