2.4.1.38: beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase

This is an abbreviated version!
For detailed information about beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase, go to the full flat file.

Reaction

Synonyms

(alpha4Gal-T1), 4betaGalT, acetyllactosamine synthetase, alpha-1,4-galactosyltransferase I, B4GALT1, beta 1, 4-GalT-I, beta 1,4-galactosyltransferase 1, beta 1,4-GalT-I, beta 1,4GalT V, beta(1,4)-galactosyltransferase, beta(1,4)-GalT, beta(1,4)-GT, beta-1,4 galactosyltransferase I, beta-1,4 galactosyltransferase V, beta-1,4-galactosyltransferase, beta-1,4-galactosyltransferase 1, beta-1,4-galactosyltransferase I, beta-1,4-galactosyltransferase IV, beta-1,4-galactosyltransferase-I, beta-1,4-GalT, beta-1,4-GalT I, beta-1,4-GalT V, beta-1,4-GalT-I, beta-1,4-GalT5, beta-1,4-GalT6, beta-1,4-GalT7, beta-1,4-GT-IV, beta-N-acetyl-beta1-4-galactosyltransferase, beta-N-acetylglucosaminide beta1-4-galactosyltransferase, beta1,4-Gal-transferase T1, beta1,4-galactosyltransferase, beta1,4-galactosyltransferase 1, beta1,4-galactosyltransferase 7, beta1,4-galactosyltransferase I, beta1,4-galactosyltransferase II, beta1,4-galactosyltransferase V, beta1,4-galactosyltransferase-1, beta1,4-galactosyltransferase-I, beta1,4-galactosyltransferase1, beta1,4-GalT1, beta1,4-GalT7, beta1,4-GT, beta1,4-GT 1, beta1,4GalT II, beta1,4GT1, beta1-4-galactosyltransferase, beta1-4GalT, beta1-4GalT1, beta4 Gal-transferase, beta4-GalT-I, beta4-GalT-II, beta4-GalT-III, beta4-GalT-IV, beta4-GalT-V, beta4Gal-T1, beta4GalT, beta4GalT-II, beta4GalT1, beta4GalT7, betaGalT, betaGalT-1, betaGALT1, betaGT, EC 2.4.1.98, Gal-T, Gal-T1, galactosyltransferase 7, galactosyltransferase, uridine diphosphogalactose-acetylglucosamine, GalNAcT2, GALT, GalT I, GalT V, GalT1, GalTase, GalTI, glycoprotein 4-beta-galactosyl-transferase, glycoprotein beta-galactosyltransferase, HP0826, lactosamine synthase, lactosamine synthetase, lactose synthetase A protein, LgtB, LgtB-A, LgtB-B, LgtH, More, N-acetylglucosamine beta1,4 galactosyltransferase, N-acetyllactosamine synthetase, NAL synthetase, thyroid galactosyltransferase, thyroid glycoprotein beta-galactosyltransferase, UDP-beta-1,4-galactosyltransferase, UDP-Gal:betaGlcNAc beta-1,4-galactosyltransferase, polypeptide 1, UDP-Gal:N-acetylglucosamine beta1-4-galactosyltransferase, UDP-galactose N-acetylglucosamine beta-4-galactosyltransferase, UDP-galactose-acetylglucosamine galactosyltransferase, UDP-galactose-N-acetylglucosamine beta-1,4-galactosyltransferase, UDP-galactose-N-acetylglucosamine galactosyltransferase, UDP-galactose:N-acetylglucosaminide beta1-4-galactosyltransferase, UDP-N-acetylgalactosamine:polypeptide N-acetylgalactosaminyltransferase 2, UDPgalactose-glycoprotein galactosyltransferase, UDPgalactose-N-acetylglucosamine beta-D-galactosyltransferase, UDPgalactose:N-acetyl-beta-D-glucosaminylglycopeptide beta-1,4-galactosyltransferase, UDPgalactose:N-acetylglucosaminyl(beta1-4)galactosyltransferase, uridine diphosphogalactose-acetylglucosamine galactosyltransferase, uridine diphosphogalactose-glycoprotein galactosyltransferase

ECTree

     2 Transferases

         2.4 Glycosyltransferases

             2.4.1 Hexosyltransferases

                2.4.1.38 beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase

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Results	in table
37	Activating Compound
37	AA Sequence
9	Application
2	CAS Registry Number
44	Cloned(Commentary)
10	Crystallization (Commentary)
47	Disease/ Diagnostics
13	Expression
21	General Information
6	General Stability
4	IC50 Value
74	Inhibitors
23	kcat/KM [mM/s]
9	Ki Value [mM]
133	KM Value [mM]
76	Localization
68	Metals/Ions
23	Molecular Weight [Da]
55	Natural Substrates/ Products (Substrates)
149	Organism
10	Pathway
53	PDB ID
24	pH Optimum
2	pH Range
1	pH Stability
5	Posttranslational Modification
60	Protein Variants
35	Purification (Commentary)
7	Reaction
1	Reaction Type
145	Reference
3	Renatured (Commentary)
145	Source Tissue
17	Specific Activity [micromol/min/mg]
12	Storage Stability
271	Substrates and Products (Substrate)
24	Subunits
205	Synonyms
1	Systematic Name
8	Temperature Optimum [°C]
1	Temperature Range [°C]
4	Temperature Stability [°C]
51	Turnover Number [1/s]

Disease

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Disease on EC 2.4.1.38 - beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase

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DISEASE

TITLE OF PUBLICATION

LINK TO PUBMED

Carcinogenesis

Glycosyltransferase expression in human colonic tissue examined by oligonucleotide arrays.

12787925

Carcinoma, Hepatocellular

Two specific inhibitors of the phosphatidylinositol 3-kinase LY294002 and wortmannin up-regulate beta1,4-galactosyltransferase I and thus sensitize SMMC-7721 human hepatocarcinoma cells to cycloheximide-induced apoptosis.

17557191

Glioma

Beta1,4-galactosyltransferase V functions as a positive growth regulator in glioma.

16461357

Glioma

Down-regulation of beta1,4-galactosyltransferase V is a critical part of etoposide-induced apoptotic process and could be mediated by decreasing Sp1 levels in human glioma cells.

16873896

Glioma

Down-regulation of the expression of beta1,4-galactosyltransferase V promotes integrin beta1 maturation.

16564504

Glioma

Functional interaction of E1AF and Sp1 in glioma invasion.

17938207

Lung Neoplasms

Elevated beta1,4-galactosyltransferase I in highly metastatic human lung cancer cells. Identification of E1AF as important transcription activator.

15611127

Mucopolysaccharidosis III

Impairment of glycosaminoglycan synthesis in mucopolysaccharidosis type IIIA cells by using siRNA: a potential therapeutic approach for Sanfilippo disease.

19690584

Neoplasm Metastasis

Glycosyltransferase expression in human colonic tissue examined by oligonucleotide arrays.

12787925

Neoplasms

Beta1,4-galactosyltransferase V functions as a positive growth regulator in glioma.

16461357

Neoplasms

beta4GalT-II increases cisplatin-induced apoptosis in HeLa cells depending on its Golgi localization.

17470362

Neoplasms

Characterization and immunoassay of human tumor-associated galactosyltransferase isoenzyme II.

3136919

Neoplasms

[Preparative isolation of human galactosyltransferase. A comparison of methods]

2128192

Ovarian Neoplasms

[Preparative isolation of human galactosyltransferase. A comparison of methods]

2128192

Uterine Cervical Neoplasms

beta4GalT-II increases cisplatin-induced apoptosis in HeLa cells depending on its Golgi localization.

17470362

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